ZMP
zgc:110460
Ensembl ID:
ZFIN IDs:
Description:
Eukaryotic translation initiation factor 2A [Source:UniProtKB/Swiss-Prot;Acc:Q4QRJ7]
Human Orthologue:
EIF2A
Human Description:
eukaryotic translation initiation factor 2A, 65kDa [Source:HGNC Symbol;Acc:3254]
Mouse Orthologue:
Eif2a
Mouse Description:
eukaryotic translation initiation factor 2a Gene [Source:MGI Symbol;Acc:MGI:1098684]
Alleles
There are 7 alleles of this gene:
| Allele Name | Consequence | Status | Availability |
|---|---|---|---|
| sa15233 | Essential Splice Site | Available for shipment | Available now |
| sa10155 | Nonsense | Available for shipment | Available now |
| sa19191 | Nonsense | Mutation detected in F1 DNA | Not yet available |
| sa23204 | Essential Splice Site | Available for shipment | Available now |
| sa36555 | Nonsense | Available for shipment | Available now |
| sa795 | Essential Splice Site | Available for shipment | Available now |
| sa43024 | Essential Splice Site | Mutation detected in F1 DNA | Not yet available |
Mutation Details
Allele Name:
sa15233
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000074168 | Essential Splice Site | 158 | 580 | 6 | 24 |
Genomic Location (Zv9):
Chromosome 18 (position 2460200)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 18 | 3468102 |
| GRCz11 | 18 | 3565187 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GTTCGAAATGTCAATAATGAGCTTCACTTTTTTGAAAACAACAACTTTGG[T/A]GAGACATTGTTTGCTTTGTTTATTGTGCATGTTAKGTTTTAAATGARTGA
Long Flanking Sequence:
TTTTCAGAGACGCAGGATAACCCTCAAGGAGAAGCAAACCTGCAGCTTTGGGACTTGCAAACAGGCGCCTGCATGAAAGCTTTCTATCAGAAGAAGATGACAGGATGGTTCGTGACTTTTGATAAATAACATTCCCTTCTATATCAACATCTTCTGTTTTCTGATTTGTGTTTACTGGCATGAGGGGTGGGATCAAATTGTCATTTGCACTAATAGCAAACCATCTAATCAATCCCTATTGGACAAAACCAGACCCCGCCTACAATTGTTTGTAAAGCTGTTTCACTTGGTTTAACATCAAGATGGAGAGGAAAACACGATCACAACTTCTATTTCATGCTAACTTAGAGTTTTTGTATTATTGTCAGTGTATTTCTTTTCTGTCTGTAACTGTAAAACGTCTGTTTTTTTCACAGGTGTCCAAGCTGGGCAGACGATGAAAGTATTTCTGTTCGAAATGTCAATAATGAGCTTCACTTTTTTGAAAACAACAACTTTGG[T/A]GAGACATTGTTTGCTTTGTTTATTGTGCATGTTATGTTTTAAATGAGTGATAAATAGCATGGGCATGTTTATGTTCATTTGAATGTATAAAAGCTCACTATTTCTTTAAGAATTAACAACATTGTTTTTAGTAGTTTAGCTTTTTCTTGGTTGTTTTAATGAAATTCTGTTTCTGTATTCTGTTGAATTAATTTGGGATATGAACCTATTCTGTGTAGCCTGCAAGTAATGTGAATATACGGCTGACTGAATGATATGTGCAAAAAAGAAAAGAAATCACAGAAAAATAGATAATCAGCATAATAAATGTCAAATCTATTTCTTACAATCTTGTTTACTACAAAGCAGAAAGTTAATTGTTAATTTAAATTACTGTTATTGTCAATACAAAACATTACAAATCCATTAAGTATATGAATGAATGAATGATTTTCACAAATCTGAGGTACAATATACCCTCCCCTGCCACTTTATTAGGTACACCTGTCCAACTGCTTGTT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa10155
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000074168 | Nonsense | 268 | 580 | 9 | 24 |
| ENSDART00000074168 | Nonsense | 268 | 580 | 9 | 24 |
Genomic Location (Zv9):
Chromosome 18 (position 2463741)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 18 | 3464561 |
| GRCz11 | 18 | 3561646 |
KASP Assay ID:
2261-1701.1 (used for ordering genotyping assays)
KASP Sequence:
GAGAGCAGACGCTACATTACGTCGCCACCAATGGAGAAAGTGCTGTCGTT[C/T]AGCTACGTAAGTAACATATTAAGTKAGTAATTAACTACTAGGGCTGCACA
Long Flanking Sequence:
CATTCAAATTCAAAAGAGGGCGGAGCTACAACTGACTGTCAGCATAGTGGCTGATTAAAAACAGGACTAACATTATCTGAAAAACATGTCTCAGAAGACGTCTATAATACATGTTTTTCAGTAGATACGGTATGCTAATGAAGGAGAGATCATCACTAATGGGCGGGGCTTTCCCTCTGATGACACATACGAAGGGAGAATGTCAATCAAAGTGTTTCTGCAGACTGTTATAATCAAGTGTGATGATAAAAAATAAAGTTAATTAATTTTTACCATTAGAGGCTGGATATATTCACACAATGTTGCCTCACATTAGACCCTTTATGGAAGTGATTTTTGCTTAATAGAGGTTTTCACGTACGCATTAATGCTTTGCATTGTCTTCCAAAGCCACTGCAGTTCTTGTCACCGCCAGCACAGAGGTGGATAAAACAGGAGCCTCTTATTATGGAGAGCAGACGCTACATTACGTCGCCACCAATGGAGAAAGTGCTGTCGTT[C/T]AGCTACGTAAGTAACATATTAAGTTAGTAATTAACTACTAGGGCTGCACAATATATTGTTTCAGCATCAACATCGCAATGTGCACATTGTCTGCAATGTGAATTCACTTTTAGTTCAGTTTTAGTTTATTAGGAAATGTGAGTAGGGCTATATATACAGTTAAAGCCAGAATTATTAACCCTCCCCTGTTTATTTTTACCCCAATTTCTGTTTAACAGAGAGAAGATTTTTTTCAGCACATTTCTAATCATAATAGTTTTAATAACTCATCTCTAATAACTGATTTATTTACTCTTCGCCATGATGCCAGTAAATAATATTTTACTTGATATTTTTCAAGACACTTCTATACAGCTTAAAGTGACATTTAAAGGCTTAACTAGATTAATTAGGTTAACTAGGCAGGTTAGGGTAATTAGGCAAGTTATTGTATAACGATGGTTTGTTCTGTAGACTATCGAAAATTAATTAGCTTAAAGGGGCTAATAATTTTGACCTTA
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa19191
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000074168 | Nonsense | 268 | 580 | 9 | 24 |
| ENSDART00000074168 | Nonsense | 268 | 580 | 9 | 24 |
Genomic Location (Zv9):
Chromosome 18 (position 2463741)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 18 | 3464561 |
| GRCz11 | 18 | 3561646 |
KASP Assay ID:
2261-1701.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GAGAGCAGACGCTACATTACGTCGCCACCAATGGAGAAAGTGCTGTCGTT[C/T]AGCTACGTAAGTAACATATTAAGTTAGTAATTAACTACTAGGGCTGCACA
Long Flanking Sequence:
CATTCAAATTCAAAAGAGGGCGGAGCTACAACTGACTGTCAGCATAGTGGCTGATTAAAAACAGGACTAACATTATCTGAAAAACATGTCTCAGAAGACGTCTATAATACATGTTTTTCAGTAGATACGGTATGCTAATGAAGGAGAGATCATCACTAATGGGCGGGGCTTTCCCTCTGATGACACATACGAAGGGAGAATGTCAATCAAAGTGTTTCTGCAGACTGTTATAATCAAGTGTGATGATAAAAAATAAAGTTAATTAATTTTTACCATTAGAGGCTGGATATATTCACACAATGTTGCCTCACATTAGACCCTTTATGGAAGTGATTTTTGCTTAATAGAGGTTTTCACGTACGCATTAATGCTTTGCATTGTCTTCCAAAGCCACTGCAGTTCTTGTCACCGCCAGCACAGAGGTGGATAAAACAGGAGCCTCTTATTATGGAGAGCAGACGCTACATTACGTCGCCACCAATGGAGAAAGTGCTGTCGTT[C/T]AGCTACGTAAGTAACATATTAAGTTAGTAATTAACTACTAGGGCTGCACAATATATTGTTTCAGCATCAACATCGCAATGTGCACATTGTCTGCAATGTGAATTCACTTTTAGTTCAGTTTTAGTTTATTAGGAAATGTGAGTAGGGCTATATATACAGTTAAAGCCAGAATTATTAACCCTCCCCTGTTTATTTTTACCCCAATTTCTGTTTAACAGAGAGAAGATTTTTTTCAGCACATTTCTAATCATAATAGTTTTAATAACTCATCTCTAATAACTGATTTATTTACTCTTCGCCATGATGCCAGTAAATAATATTTTACTTGATATTTTTCAAGACACTTCTATACAGCTTAAAGTGACATTTAAAGGCTTAACTAGATTAATTAGGTTAACTAGGCAGGTTAGGGTAATTAGGCAAGTTATTGTATAACGATGGTTTGTTCTGTAGACTATCGAAAATTAATTAGCTTAAAGGGGCTAATAATTTTGACCTTA
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa23204
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000074168 | Essential Splice Site | 269 | 580 | 9 | 24 |
Genomic Location (Zv9):
Chromosome 18 (position 2463748)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 18 | 3464554 |
| GRCz11 | 18 | 3561639 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GACGCTACATTACGTCGCCACCAATGGAGAAAGTGCTGTCGTTCAGCTAC[G/A]TAAGTAACATATTAAGTTAGTAATTAACTACTAGGGCTGCACAATATATT
Long Flanking Sequence:
ATTCAAAAGAGGGCGGAGCTACAACTGACTGTCAGCATAGTGGCTGATTAAAAACAGGACTAACATTATCTGAAAAACATGTCTCAGAAGACGTCTATAATACATGTTTTTCAGTAGATACGGTATGCTAATGAAGGAGAGATCATCACTAATGGGCGGGGCTTTCCCTCTGATGACACATACGAAGGGAGAATGTCAATCAAAGTGTTTCTGCAGACTGTTATAATCAAGTGTGATGATAAAAAATAAAGTTAATTAATTTTTACCATTAGAGGCTGGATATATTCACACAATGTTGCCTCACATTAGACCCTTTATGGAAGTGATTTTTGCTTAATAGAGGTTTTCACGTACGCATTAATGCTTTGCATTGTCTTCCAAAGCCACTGCAGTTCTTGTCACCGCCAGCACAGAGGTGGATAAAACAGGAGCCTCTTATTATGGAGAGCAGACGCTACATTACGTCGCCACCAATGGAGAAAGTGCTGTCGTTCAGCTAC[G/A]TAAGTAACATATTAAGTTAGTAATTAACTACTAGGGCTGCACAATATATTGTTTCAGCATCAACATCGCAATGTGCACATTGTCTGCAATGTGAATTCACTTTTAGTTCAGTTTTAGTTTATTAGGAAATGTGAGTAGGGCTATATATACAGTTAAAGCCAGAATTATTAACCCTCCCCTGTTTATTTTTACCCCAATTTCTGTTTAACAGAGAGAAGATTTTTTTCAGCACATTTCTAATCATAATAGTTTTAATAACTCATCTCTAATAACTGATTTATTTACTCTTCGCCATGATGCCAGTAAATAATATTTTACTTGATATTTTTCAAGACACTTCTATACAGCTTAAAGTGACATTTAAAGGCTTAACTAGATTAATTAGGTTAACTAGGCAGGTTAGGGTAATTAGGCAAGTTATTGTATAACGATGGTTTGTTCTGTAGACTATCGAAAATTAATTAGCTTAAAGGGGCTAATAATTTTGACCTTAAAATGTT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa36555
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000074168 | Nonsense | 564 | 580 | 14 | 24 |
Genomic Location (Zv9):
Chromosome 18 (position 2472588)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 18 | 3455714 |
| GRCz11 | 18 | 3552799 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GCTAAAACCATAATTATAACATTTCCCCTTTTTTACAGCTTGAGAAGATG[C/T]AGAAGGAGGCCCAGCTGTTGAAAGAGCTTGAAGACCTTGAATTAGGATTA
Long Flanking Sequence:
GTACTATACTATATATATATATATTCTTCTTCAATGTTTTAATGTAATAATGTGATTTTTCTGTTTATCTGGCAGAAACTCAAAGCCATTGATGAACTAAAGGAGCAGCAGGCTGCCGGAAAAGTCATGCAAAAAAACCAGGTACCACCTTTTTATTGTTATGTTTTTATATGCTACCCGACAAAGTCTTGTCGTCTATAAATTTTTAATAAGTTGACTTCTAGTTGATCAATTGGTGTCAGAAGTGGCTTAAATTCAATTAAATTCAATTCATGTTTATTTTTTAAGTGATTTTACTATGTAGATTGTGTCAAAGCCGCTTAACATAGAAGTTTTAGTAAAGTCCAGTTTTCAGATATGATAAACAAAGGCCTCTAGATTACACTTTTTTTTTACCAAAATAAAATATGATCATGCCTTGATTTAGCTTTCATAAGACCTTCATAACATGCTAAAACCATAATTATAACATTTCCCCTTTTTTACAGCTTGAGAAGATG[C/T]AGAAGGAGGCCCAGCTGTTGAAAGAGCTTGAAGACCTTGAATTAGGATTATAAACTCACTGTACCAGTTTTCTCCATTGGTCATCATTGGTTTCCAAGCATTGCTTTGTCATACTCTCATTAAAATGAATGGAGATGTTTTTCTTCATGTCCAATAAACAACAGCCTGTTTTGCTTATTTGTTCATGGCTAGAAATTAAGGACTACATTCTTAAAAGCAATATTGCTATGCAATGTGACGTACAGCACAAAGAAACACCTTGCAATGCGAAATAAAAATGTAGAAATTCAAACGGCGTGACTTTTATTATGCCGGTTGGGGCAGCCGGAAATGTTCCTTTCTCCGCCAGTGTGAAACTAAAGCAGCCACAGATTTCAGCACAACGCAGCTGAAATTGGTAACAAATAAACCGAACGGGACAAGCTAAAAGCAGCTGATATTTCAGGTTTGATGAGAAAACACTGCATTATGACTAGTTTCCTGTTTGTGGGGTGTTTTGT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa795
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
T > G
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000074168 | Essential Splice Site | None | 580 | 18 | 24 |
Genomic Location (Zv9):
Chromosome 18 (position 2483204)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 18 | 3445098 |
| GRCz11 | 18 | 3542183 |
KASP Assay ID:
554-0700.1 (used for ordering genotyping assays)
KASP Sequence:
GATCATTTCTCCAACAAGAAATGCCTCGCCTGGTTTTATGAATATGCAGG[T/G]ATGTGAATCGTAGCGGTTAACATGAAACTGCATTTACAAACTGATCTTTT
Long Flanking Sequence:
ACATATTTGAGTTTGAGCATGACTTATACAGTGTATTAAATATGAAGGTGTTTTTCCTCCTGACTTTAGCTGCTGCTACACTTGAATGGACTCGATGCCCAAAGGTATACAGGTAGAGCTGCTTCCTGCTCTTTGCTTAACCTGAAATATCCAATTGGACGTAAAGGAAAGCAGCTGTCGGCTTCAATCTGTCCTGTTCATTTGTTATTTGTCTAGTAAGACCAAACCAACTCACCCGGAGCTCCATTATGCCTGTCAAGAAGAAAAGAAAGTCGTCCGGCTCGGAAGATCCTAGTATTAGAAAATGTAAAATCACCAGGTACCAATATGTCTGCATTAATGTTTTCTCATTGTCTTTCACTTTTTTATTATTAAGTTATTGAATCGTCCTGTCTTTAATAATCCAGTTACTGTAGGACACAAACTTCAGGACGGCTGGTAAACCCAGAGGATCATTTCTCCAACAAGAAATGCCTCGCCTGGTTTTATGAATATGCAGG[T/G]ATGTGAATCGTAGCGGTTAACATGAAACTGCATTTACAAACTGATCTTTTACTGTGGAAATGAAACCTAAAGTAAAAGAAATTGTTATAAGAAAATAACGATGGACAAAGACAAATATTTATTTATTAGGCTGGTGTAAATATGTCCTTCATAGAGCGGTATCAAAACAATGTAAGATACAGCTTTCATTTTTTTGTGTCTTGTTTGTTGATCAAACTTAGGTTTTTCAATCAGAATTTCTGGTTTTGTATTTTGAAATATTGAATTTGATGTTCTGAATTTCTTCGTCTTGAAAACTTACCTGCATTTCTACAGTGTGGACATCTGCAGTCTAGAACTTTAGATCTGAAGTTTGAAAATGCGCGCCTATAAAAATGTGCTCTTAAAATTCCTAAATTTCAGATGTTCAATATTCAAGTTAAAGGTGCTGTATGTACATTTGACTCTTCTAAAGCATAAAAATACCATAATTTGTTTGCAGGCGCTTGCGTGTTTCGAAC
Associated Phenotype:
Normal
| Stage | Entity | Quality | Tag |
|---|---|---|---|
| Larval:Day 5 ZFS:0000037 |
whole organism ZFA:0001094 |
quality PATO:0000001 |
normal PATO:0000461 |
Mutation Details
Allele Name:
sa43024
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000074168 | Essential Splice Site | None | 580 | 21 | 24 |
Genomic Location (Zv9):
Chromosome 18 (position 2485444)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 18 | 3442858 |
| GRCz11 | 18 | 3539943 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACCCGGTTATATTCAAGAGTATCTACAGATACGCCTTTGACTTTGCCAGG[G/A]TGAGATGTGTTTAGAGAAGATGATGCATTTGAGGCTACAAATCCCTTGTG
Long Flanking Sequence:
TAAACCTGTATGGAGAAAGTTAAATTGGGTAAATTGATCAAAACTGATGTGTTGTGCTTTGAAATGCCTGCAGGGTCGGATGACATTGTCGGGCCAGAAAGCATGGAAAAATTCTGCGAGGACATTGGTGTGGAGCCAGAAAATGTAAGCAAAGTTTCATGGTTTTATCCGTTAAAAATTTGCAGCATAATAAAGATGACTCATTTTGACGTCCCTTTCAGATTGTAATGTTAGTTTTAGCCTGGAAACTTGAAGCAACAAATATGGGATTTTTCACAAAAGAAGAGTGGCTGAAGGGAATGACGTCACTACAGTAAGACTCCGATCACATGACAAAACAATTAAAAGCCTTTTATCCTATCAGCTGTTGACTTCTCTGATTTCTCTACAGTTGTGACGGCACAGAAAGATTACAAGGCAAACTGGATTATATGCGCTCTCTGCTCAACGACCCGGTTATATTCAAGAGTATCTACAGATACGCCTTTGACTTTGCCAGG[G/A]TGAGATGTGTTTAGAGAAGATGATGCATTTGAGGCTACAAATCCCTTGTGTTATTGTTTTTATGCAGTTTATTAATGTTACTTTTCAGCTTAGGAGATTTCAAGATGCATTGATATTTTCTTTCTATTTAAATAGAAATTATTTTAAAGGATTAGCATCATTTCAAGAGTTTTTTTTCTGTGTATTATTTAGTAGTTAAAGGTGCAGTAGGGGATTGTCTTCAGAAGCATTTTTTTGTTGTGCTGGTTGAAATTCTCTTCACAGTCTAATAGTAATGATTACAGTAAATGATCTAAATGTATTTATATGTATTTTTATATTTTGGGTAATGCTGCGTTCACAACAGACGCGGCACGCGCATCAAGCGCGAGTGATTTACATGTTAAGTCAATGCAAATGTGTGAAAAGACATCCTGCGGCGCGATACGCGCGAATGGCGCGGAGCGAATGACGTGAATGGCGCGAGGCGAATTGAGCGTTTGCGCATTTGACGCGCTTAA
Associated Phenotype:
Not determined