Busch Lab

ZMP

dph1

Ensembl ID:
ENSDARG00000057973
ZFIN ID:
ZDB-GENE-050417-411
Description:
Diphthamide biosynthesis protein 1 [Source:UniProtKB/Swiss-Prot;Acc:Q567W6]
Human Orthologue:
DPH1
Human Description:
DPH1 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:3003]
Mouse Orthologue:
Dph1
Mouse Description:
DPH1 homolog (S. cerevisiae) Gene [Source:MGI Symbol;Acc:MGI:2151233]

Alleles

There are 5 alleles of this gene:

Allele Name Consequence Status Availability
sa35893 Nonsense Mutation detected in F1 DNA Not yet available
sa1222 Essential Splice Site Available for shipment Available now
sa16246 Essential Splice Site Available for shipment Available now
sa32037 Missense, Nonsense Available for shipment Available now
sa22651 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa35893
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000080740 Nonsense 128 381 4 11
ENSDART00000110408 Nonsense 143 439 4 12
ENSDART00000140214 None None 51 None 2
Genomic Location (Zv9):
Chromosome 15 (position 25324719)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 26054647
GRCz11 15 25989912
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACTGCCCGCGCTTTGGGAGCCGACTTCATGGTGCATTATGGGCACAGCTG[T/A]CTCAGTGAGTCAAACAGAAATGCGCAATCATTATTATGTGCATTTGCTTT
Long Flanking Sequence:
AGCACTTGCAAAATTTCAACCTCTAACCTTTCGGCCTCCAGCATACATTGTGCATTTGTTGGACAGACGGTATGCAACCATAGCTATTAACCTCAGCATGGAAAAAAGTGACCCTTTGCTACCATAAGTGAACATTTATGTTAATAGTAGCCCATTGCTCTGTTGTCTCTGAAGGTTATTGGAGATGTTTTGCCAGAGTGCATCAGTTTACGGCTAGCGGGAGCCCACTTAACTGGAGACATGGATGTCTGAGTGACATTTCTGCTGGAGAAGTGATTGATCTGCCAGCTGTGTGGACCTGTCATTTTACTTCCAGCCTGATTGATTTGAATGGCAATAGGGTGGTGATCAAGGTCATTGATTGGCTGTTTGTGTTTTGTCAGATTCACAGAGGCGGACACTCTGGTGATGGGAGATGTGACATACGGGGCCTGCTGCGTGGACGACTTCACTGCCCGCGCTTTGGGAGCCGACTTCATGGTGCATTATGGGCACAGCTG[T/A]CTCAGTGAGTCAAACAGAAATGCGCAATCATTATTATGTGCATTTGCTTTCCCTAATGTCATTTCAAAACATGTGTGGCTTTCTTCTGTGAAATGGATTTATATTATGAGTTATAATACATTTATAAAACTTCTTTTAATGTGTTTTTATTATTTTGGAGGTTAATTAACATCATTTGGAACATTGTATGTATGTATATATATATATATATATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAGAGGAGGTAGATATCAGATCACAAGTATAATCAGGAGCAGAACTAGGGATGCTCATTTCGGTTAATTTTGCTAACCAACAACCGCCACTCATTAATCGGTTATTAACGGTTAACTGGTCAGATTACTATTAATTTTATATTAAACAAATTGATGTGTCTATTTTGTGTCTGACACATTAAATATTGCATTTTAAAATA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa1222
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000080740 Essential Splice Site 245 381 7 11
ENSDART00000110408 Essential Splice Site 260 439 7 12
ENSDART00000140214 None None 51 None 2
Genomic Location (Zv9):
Chromosome 15 (position 25300510)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 26030438
GRCz11 15 25965703
KASP Assay ID:
554-1131.1 (used for ordering genotyping assays)
KASP Sequence:
TTCATTTGGAATCCATCATGATTGCCAACCCAGACACACCTGCCTACAGG[T/C]AAACCAAACCAACGTTTACTACAGCAAGTATCATTATTATCATGGCTTGT
Long Flanking Sequence:
CTAATTGTGGCTACGTTCCTTTGGGTGTCCATCAGCTTTGCCAGGTTAATCTATACTCTCATTACCTATGGCAGGTCTTCTCCTGTCAGCACAGCAGAGGATAATCAGAATATTAAGTTCTGTTTGCATGCTGTCCGCGTTATGACCTAATCATATCATGGAGGGGTTTATTTGTGGAGTATTTGGATAATAGCCCAACAGCCTCCATGTCTATGACTGCTTTCCGGCTAGAGTGAGTAGGTCTTGCCCTGATCGCTTGTTCAATGTTAGGAGGGTGCTGATCCGGTTTACCCATCCTCTAGGCTGAGACCTGTTGGCCTTTATATTTTCAAACACAAATCCCAGAGAGAAGAAGGGGTTAGCGGAGTTTTACTGTTTGTGCACACTCAGATTGTCTTTCTCTCTGATAGAGTTGTGTTTCTGTCTATAGATATCTTGGGGATGGAAGATTTCATTTGGAATCCATCATGATTGCCAACCCAGACACACCTGCCTACAGG[T/C]AAACCAAACCAACGTTTACTACAGCAAGTATCATTATTATCATGGCTTGTAGTCTTCAACATTTTTCAGGGCTGTTTAAACTTTCGGAAAGCTCTTCTAAAAAATTCATATGTGGCCCGTTTCAACTGAGTGATTCGGTATGGTTTTAAATACACAGCAGAGACATTGCACCATAATAATTTATACATATAATAATGAGCCTTGGTCAGCCCGGGCTCAAAGAAACCTTGTCATCGTCTTGATGAACAGCCAGGAAGAACATAATCTGCTGGGCCCTGTTGTTGTTTTATGAGCCCATCTAAAATTGCGAGCGGTTTCACTTTGTCCACAGATTTTGCGATCTTGTCTGTATTTGAAATAACAAACTTTTTAAGCTCCTATTAGTATGCTCGTGATCAATGAATTGAAGCAATCTGATATCCGATCCTGTTAGAAAGGAACAAACGCGAGAATGAAGCGGGAAAAAACAAAGGAACTCAGAATGACAGAATTACTTTCTA
Associated Phenotype:
Normal
Stage Entity Quality Tag
Larval:Day 5
ZFS:0000037		 whole organism
ZFA:0001094		 quality
PATO:0000001		 normal
PATO:0000461

Mutation Details

Allele Name:
sa16246
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000080740 Essential Splice Site 297 381 8 11
ENSDART00000110408 Essential Splice Site 312 439 8 12
ENSDART00000140214 None None 51 None 2
Genomic Location (Zv9):
Chromosome 15 (position 25296798)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 26026726
GRCz11 15 25961991
KASP Assay ID:
2260-8552.1 (used for ordering genotyping assays)
KASP Sequence:
GCTCATCCTAGGCACCCTTGGTCGTCAGGGCAACCCCAAAATTTTRGAGG[T/C]AAGACCATCTGCTACCTATTGTCCTACAGTATGTTTTTTTNATCAGAGTAA
Long Flanking Sequence:
AAACGGGAGATCTGCATCTTGTATGTGCAGTCGACAAATCTGCAACAACTGTGTGATGCTATCATGTCAATATGGAGCAAAATCTCCAGAATATTTCCAGTACCTTGTTGAATCTATGCCACGAAGGATTAAGGCAGTTCTGAAGGCAAAATTAGGTCCAATCCAGTACTAGTGAGGTGTACCTAACAAAGTGTGGATGTTCCAAGGTTGTACTTTGTGGGATTTATAACTTGGATCCAAGCAATCTAGACCAACAGCAAAACCCTGCTGTCACAGTGGAAAGTTTATTTTTGATTAGTATCTGTTTGATTAGTGTCTCATTGTTGTCCTCCATACCTGCAGGTATGACCCATACAGTAAAGTGTTTTCTCGAGAATATTATGACCATGATGCAATGCGGGCCACCAGACTGAAAGCCATCGAGAGTGCCCGCTCAGCACAGAGGTGGGGGCTCATCCTAGGCACCCTTGGTCGTCAGGGCAACCCCAAAATTTTGGAGG[T/C]AAGACCATCTGCTACCTATTGTCCTACAGTATGTTTTTTTATCAGAGTAAAGATTACACTGTCCTACATGTGCACCGAAACAGACACACACACCCTGCGGCATTTGGCCAGGAGGAAGGTTCAACAGGGGTGTTAATGGAATATTTTGTGAGGGGCAGGTCATCTCACTCTCTTCCTCTACTTCTCATTCAGATCCTTCTCTGTTTGTTCTCTGCCTGTTTTCATCTGTTCATTTGTATGTGTTTGGATTGGACTTTGTTTTGGCAGATTTCCTCTCTTTGCCGTTTCATCCTTTTTAACTGGTGTGCATAAACAAGACGAGTGAGATGAATTCAGCATCTAGATAAACAGACAGTGGATGGCGATTCTGAAGGAGATCTCTGTAGCTCTCCTCAGTGTTTTTTTTCTATCCCTGAATCTCATGACGCATTCCTGTTGGAGTGCCTTTTTGATCAGTGCTTCTCAACTGCTGGGCTGCATTCTAAAGTAGGCGTCTGGTC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa32037
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > A
Consequence:
Missense, Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000080740 Missense 345 381 10 11
ENSDART00000110408 Nonsense 386 439 11 12
ENSDART00000140214 Missense 15 51 1 2
Genomic Location (Zv9):
Chromosome 15 (position 25248963)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 25978891
GRCz11 15 25914156
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GTGTTTCAGGCAGCAGTGGCGCTACAGCAGGTTGGATGGCAGGATGTGTA[T/A]CCCATGGATTTCTATTCCAATCAGAGTCTGGGGGCCTGGACTCCTAATCA
Long Flanking Sequence:
TCATACACCAGTCTGAACTATGTTTTATTTTATTTTATTAATCACATTGACATCGGGTAATTACAATGTAAATGCAACAGACAATAGTACAAACAATGCTTTTTGCAATAAGGAAGATATAACAGTTTTAAAGAAGTGTAACAGTGGTATAGCAGCAAGCAAGCAAGAAAAAGGTCACAATGTAACCACAGAAGAAGCTTTAAATAGAAAATTAGCAAAAATATTTTTTGAAGGAAGATGCTAATAGTCTAATCCAATTCCATGACCTAAGCTAAGCTAAAATTGTTCCTGCCAGATCTGGAGATCACAACTAGAACTCCCTTGATATTGGACTGGATTCTGTGGCTGATGTGTGTATGAAGCCCATTGTCCTGTTGTTAATCCTACAGTAAGTCAGCATGCTGATGTGTTTAATAAACTCACACAATGTGTGTATGTGTGTGTGTGTGTGTGTTTCAGGCAGCAGTGGCGCTACAGCAGGTTGGATGGCAGGATGTGTA[T/A]CCCATGGATTTCTATTCCAATCAGAGTCTGGGGGCCTGGACTCCTAATCATCCGGATAACCAACCTAAACGGCCTGCACGCAAAACCGCACAGGTGTGTATGCTGAAAGGGTTTTTAGAAAAAAAAAGCTTTAAATATTATTTCATTATCGTGTTCAAAGTATAATGTTTATTCCCATATTTCATTATTAATTAGGTAACAATTTACAATAAAGTTTTATTAGTTGATGGTAATGCATTTACTAACATGAACAATACATTTATTACAGTATTTGTTCATGTTAGTTAACATTAGTTAATGAAAATACAGTTGTTCATCGTTAATGTTAACTGACTGTGCATTAACTAATGTTGTTAATAACATTAGTGTTAATAATAGATGTTAATAATGCATTAGTAAATGTTGAACTAATAAATGGCGGTCCAGTATTATTCATAATAAGTTCAAGTTAGTAATCAAATTCACCAAAGAAAGCTGTTGTGACCAATAATTTATTTATT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa22651
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000080740 None None 381 11 11
ENSDART00000110408 Nonsense 437 439 12 12
ENSDART00000140214 None None 51 2 2
Genomic Location (Zv9):
Chromosome 15 (position 25245766)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 25975694
GRCz11 15 25910959
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GTCAGCAGGTGATCAGCTGTGGTCAGGAACAGAGCGCCTCCTGTGGTTGT[C/T]AACCAAAATAACATACAGCCTCATGAACATCTGCCGGAGACAAGCGGACC
Long Flanking Sequence:
ATTTTTTGTGAAACCCATCATACTCTTTACAAGATTTTTGCTTGATGATTATTTCATTCATTGACTGACTGACTGAAAAAGTTTTCAATTAGTAGCAGATAAATAGACAATGTATTTTAATTTCCAGTTCTGTGAAAATCAGCGGAAAAATAACAAAAATTCAGATTTTGTCGTTTCTCATGACCAACTTAAAAGCACCTGGGGATTTTAGGACCAGTACTTTAAACAGAAATGATTTTTTAATCCCTTAATTACTCTTCTAAGTGTATGATTAATCCACCAATATAACAGACACAATCTGCGAGTCTCTAAATCCACACAGGATGTCTGTCCTGTGTTTTATTCCTTATTGTATCTCTCTCCTTTTATCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTTTTATCAGAAGGCTGGTCAGCAGGTGATCAGCTGTGGTCAGGAACAGAGCGCCTCCTGTGGTTGT[C/T]AACCAAAATAACATACAGCCTCATGAACATCTGCCGGAGACAAGCGGACCAATCACACTTCATCACATCAGCCTTCTGTTCACACGCACCGTCAGTCAGTCAGTCAGTGAGTGAGTGTGTGTGTGTGTATGTGTGTATGAGATAAAAGCTCCCCCTTGAATGAACAAAGTGTGGTTTCGCTTTAGTCAAACGTAAGCATGTTGTCCCTCACCTACAAAAAGAAAGGGGCTGGCAGACATGTTTTCATGGTTGACCTTCATCCCTTCAGAATTACAGCAGGAAAGAGTGGATTCTTTCTGTGTGTATGAAGAGAAAATACTCATTCTGTACTCTACATCCAGCTTTTTATTTGCCTTAATGCTAAGCTTCTCCGACAGAAGCACTTTGAATGTTTTGTACAGGATATCTTTTAATTATGGGCAAAAATAAAATGAAATCTTTACAGTTTTCTGTCGGACTTGATTGAGTCTGAGTGCTGGTGTTATCATTATCAAAAAGCC
Associated Phenotype:
Not determined