Busch Lab

ZMP

mapkapk2b

Ensembl ID:
ENSDARG00000018530
ZFIN ID:
ZDB-GENE-071018-1
Description:
mitogen-activated protein kinase-activated protein kinase 2b [Source:RefSeq peptide;Acc:NP_00109527
Human Orthologue:
MAPKAPK2
Human Description:
mitogen-activated protein kinase-activated protein kinase 2 [Source:HGNC Symbol;Acc:6887]
Mouse Orthologue:
Mapkapk2
Mouse Description:
MAP kinase-activated protein kinase 2 Gene [Source:MGI Symbol;Acc:MGI:109298]

Alleles

There are 5 alleles of this gene:

Allele Name Consequence Status Availability
sa1101 Nonsense F2 line generated Not yet available
sa9002 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa21345 Essential Splice Site Available for shipment Available now
sa18024 Essential Splice Site Available for shipment Available now

Mutation Details

Allele Name:
sa1101
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000003954 Nonsense 56 397 1 10
Genomic Location (Zv9):
Chromosome 8 (position 38577742)
Other Location(s):
Assembly Chromosome Position
GRCz10 8 37433157
GRCz11 8 37465591
KASP Assay ID:
554-1003.1 (used for ordering genotyping assays)
KASP Sequence:
TCAAAAAGAAAGTAATAACAGAGGAGTATAAGCTTGCAGGACAAGTACTC[G/T]GAATAGGCATTAATGGAAAGGTTWGGGAGATATTCCAGAAGAAAAGTGGC
Long Flanking Sequence:
CTGGCCATTGAGCTGAATTTGTTATGATAACCTGGCAACCCTTGTTTGTCAGAATGTGTGGTAATCTGTTTTACAGTTAAAGTGTACTGTAACTGACCACTGTCTTCAAAACTAAGAAGGTAAATAAATGAAAAGATATTTAACAGTTATGTCCTCTAAAGTAGCCTAATTCTACCAAAATTCTGGCTGCTTTAAATCATCAAGTGCAAAAAATAATACAGAGACATCTGTGTAAGAGAAGTGCTAACCAGCTCTTAATTGGATCCTTTAAAAATCCTTTAAGCTGGTCTAAAGAAGTTGTGCTGCACAGTCCGGGATGAACACAGTCTACCACTATGTTGGATAATACAGAAGATAAAAAGGAATCAGATTTTTCCAGTGAGCAGCAAGGGACTCAGTCTCCGATTAATGTTTTGCTTTCAGAGTCGGTGCTCAAACCTACATTGAAGATCAAAAAGAAAGTAATAACAGAGGAGTATAAGCTTGCAGGACAAGTACTC[G/T]GAATAGGCATTAATGGAAAGGTTTGGGAGATATTCCAGAAGAAAAGTGGCAGGCACTTTGCTTTAAAGGTAAGCCACCTATTTAGTTTATTTTTATTAGGCAGCTTCACAACCTAACATTATTTTTTTACATTTTCCACAGCAAAGATAGGAATGGCTGTTGGTCAAAGATTTTTGTTTACAGTAAAGTCTTGGTTCAGTTATCAATTTCTCCCCCCACCCCCATTCTGCTACATAGTTTGAGTCCACATCAATAAATCTCTTTGGTAAATAGGATCATTCTGGTATTTCTGGGAACAAACTGATGTTTCTATGCTGTAAAAACTAACAGTGCCTCAAATATTGTATTGTGTTGTATAAGTGCCTCAAAACCTTTTCTATTAGAGTTACAGGAGGGGCTGTTAACATTTCTGCCAAGAACTTATGGCATCCATTAAGTACTTAAACTATAGACTTTGTAAATTCCTTCTGCCAAAACATTCATCATTGGTTCTGCGCAGG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa9002
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000003954 Essential Splice Site 173 397 4 10
Genomic Location (Zv9):
Chromosome 8 (position 38579857)
Other Location(s):
Assembly Chromosome Position
GRCz10 8 37435272
GRCz11 8 37467706
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
AAGCTGTTGAGTTTCTRCATGGTATCAATATTGCACACAGAGACCTCAAG[G/A]TAAGCAACTCTATAGCCAAAWATCTGAYATTTATTTTAGGGTTATTACAG
Long Flanking Sequence:
CTTTATAGTACAAAAGTGGACAAAAAAGGTATAAAAGTGTACCTTTAAAAAGGTACCACACCAGTAAAACCTTTTGTACCTTTATTTCTGAGCGTGCAATATACTGAATTATCTTCAACAGATTAGATTACTTTTTTGGCTTTTTATTTTTTTTTCAAATAGCTTTTAGATTTCTTTTCCTCATATAAGTAAAAAATCCATTATTATTTTTAACCTTAATGCAATCTGTTACTTAAACAGTATGGAAGGGGGAGAACTCTTTCGCCACATTCAAGAACGTCGTGATCAAGCCTTCACTGAAAGAGGTACACATCAAACCCATACACACACACTGTCAAAAACATAGTTGAGAAAACTGATCACATCACAGAAATTAATTGTCTTCTTCCCCTCTTTTTATACTTTCCTAACAATGGGTAGAAGCCTCCGAAATAATGAGAAGTATAGGAGAAGCTGTTGAGTTTCTACATGGTATCAATATTGCACACAGAGACCTCAAG[G/A]TAAGCAACTCTATAGCCAAATATCTGACATTTATTTTAGGGTTATTACAGAATATGTTTATTTTACTTTAATTCTGTTCTTTTAAATGTCATACAATTACCCCTAAAACAATTGATAACATTCCACAAAAATATTAATGCTAAACTAACAAATGTTGCAACAAATCATCAGTAAATGAAAATGATTTCTAAAGGATCATGTGACACTGAGGTCTCTATCAAACACCTGGTACAATATAGCGCAAGATCTGTTTGGTACGATTTGTTGCTATTTTCAGAAAAAAAAAAAAAAAACGCAACCCTAATTTTTAAGTTTTATGCCGCATTCTTTAAATTGTAATTTAAAATTTAGAAATAGCTTTGAAACAAATCTTTGCTCTTAACAAAAAAAATTAAATATGTAGGCTAATGAATGTCTTTAGTGGAGTGCGTACAACACCGTTTCCTTATCAAAGTAAAGAGTAAAGGTAAAGTTAAAAGAAGATAAAGAGGCCGAATGAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa21345
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000003954 Essential Splice Site 216 397 5 10
Genomic Location (Zv9):
Chromosome 8 (position 38581584)
Other Location(s):
Assembly Chromosome Position
GRCz10 8 37436999
GRCz11 8 37469433
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACATCCAACAAATGCTTGACCACCCCATGTTATACACCTTATTTTGTTGG[T/A]AAGCAACCTTTTTGAGTCTCGATTGGAATCATAACACAATGATGCTGACA
Long Flanking Sequence:
TGGGTTATGCAGTGATTTCCATTTTAAAATATATTTATTTCCATTTAAAAACACATTACTTCATACATGACAGTTTGATTATTGCATTAAAGCTATGAAACTGAGGAGACATTCTCAGGACAAGTTCAAAACTCAGCATTAAGTTCTAATAAAAGTCTAATAGTATGATTAAAACCATAAAAAAAAAAAAAAACATCCGAATATTTTACCATGTATTACTTGTGTCCAAGTCTTCAAAAAGTTGTGTCTTACATCTATAGAAGAAGATATCTTTCCTGCTAAAATATATTGAAACAACAGTCAAACTGTTACAACATATTTTTACATATTACAATATTCAACTAATTAATTAATACATCTTTTATATGGCAGCCAGAAAATTTACTGTATTCATCAAAGCAGCCGGATGCCCAACTCAAGCTTACAGATTTTGGATTTGCCAAAGAGACCACATCCAACAAATGCTTGACCACCCCATGTTATACACCTTATTTTGTTGG[T/A]AAGCAACCTTTTTGAGTCTCGATTGGAATCATAACACAATGATGCTGACAACTGCTTTCTTTTTCAGCCCCGGAGGTGCTTGGTCCAGAGAAATATGATAAGTCATGTGACATGTGGTCATTAGGGGTCATCATGTACATCTTGTGAGTGTAAATTATATTAGTTCCTTATACTGTGATATTTTTAATTTAATTTATAACCAACATATATCCTCTTAGATTGTGTGGATATCCACCATTCTATTCAAACAATGGCTTACCACTGTCACCGGGAATGAGAAAACGAATACGGAATGGCCAATATGAATTTCCAAATCCCGAGTGGTCGCATGTGTCAGAGGAAGGTAATTGTATTATATGAACATGTTTGTTCAATATTGCAAACAATATTACTCACTGTGTGTTTTTTCTCTCTTATTTTTTTTTTTTTTTTTTTAGCAAAACAGCTCATTCGACAGCTCCTGAAAACAGATCCTACAGAGAGAATGACCATCACAGAAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa18024
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000003954 Essential Splice Site 283 397 7 10
Genomic Location (Zv9):
Chromosome 8 (position 38581929)
Other Location(s):
Assembly Chromosome Position
GRCz10 8 37437344
GRCz11 8 37469778
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GGCCAATATGAATTTCCAAATCCCGAGTGGTCGCATGTGTCAGAGGAAGG[T/C]AATTGTATTATATRAACATGTTTGTTCAAKATTGCAAACAATATTACTCA
Long Flanking Sequence:
TTAATTAATACATCTTTTATATGGCAGCCAGAAAATTTACTGTATTCATCAAAGCAGCCGGATGCCCAACTCAAGCTTACAGATTTTGGATTTGCCAAAGAGACCACATCCAACAAATGCTTGACCACCCCATGTTATACACCTTATTTTGTTGGTAAGCAACCTTTTTGAGTCTCGATTGGAATCATAACACAATGATGCTGACAACTGCTTTCTTTTTCAGCCCCGGAGGTGCTTGGTCCAGAGAAATATGATAAGTCATGTGACATGTGGTCATTAGGGGTCATCATGTACATCTTGTGAGTGTAAATTATATTAGTTCCTTATACTGTGATATTTTTAATTTAATTTATAACCAACATATATCCTCTTAGATTGTGTGGATATCCACCATTCTATTCAAACAATGGCTTACCACTGTCACCGGGAATGAGAAAACGAATACGGAATGGCCAATATGAATTTCCAAATCCCGAGTGGTCGCATGTGTCAGAGGAAGG[T/C]AATTGTATTATATGAACATGTTTGTTCAATATTGCAAACAATATTACTCACTGTGTGTTTTTTCTCTCTTATTTTTTTTTTTTTTTTTTTAGCAAAACAGCTCATTCGACAGCTCCTGAAAACAGATCCTACAGAGAGAATGACCATCACAGAATTCATGAAACAACCTTGGATCAGTGTGAGTATTGACATTTTTAGGGTTCTCAAGCACATTTTAAATGAAGAGTTGAGCACTTTTAGCTTAGCAAAAATCATTGAACTAGACAGTTAGCATCTTGCTGGAAGAGTTTCACTAATTTTCCTATTCAAAGCTGGACTATTCATCAGTTACATCTTGTACTAAGGCCTATGGAAAATGGAAAGTCATATTTTCTACTCCAATATGTCTAGAAACTTTACTCTCATTCTAGCATAATATCTTAGAAACTTGCTGCCGTACCATGACTGCAGCTGGCACAATGCAGCAGGCATTACCTAGTTACCCAGGGAATACATAATAT
Associated Phenotype:
Not determined