Busch Lab

ZMP

plcb3

Ensembl ID:
ENSDARG00000068246
ZFIN ID:
ZDB-GENE-030616-594
Description:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 [Source:RefSeq peptide;Acc:NP_0011
Human Orthologue:
PLCB3
Human Description:
phospholipase C, beta 3 (phosphatidylinositol-specific) [Source:HGNC Symbol;Acc:9056]
Mouse Orthologue:
Plcb3
Mouse Description:
phospholipase C, beta 3 Gene [Source:MGI Symbol;Acc:MGI:104778]

Alleles

There are 7 alleles of this gene:

Allele Name Consequence Status Availability
sa21109 Essential Splice Site Available for shipment Available now
sa15031 Essential Splice Site Available for shipment Available now
sa9679 Nonsense Available for shipment Available now
sa41058 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa12809 Nonsense Available for shipment Available now
sa15264 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa21109
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000098563 Essential Splice Site 33 1244 1 34

The following transcripts of ENSDARG00000068246 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 7 (position 60827236)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 60046201
GRCz11 7 60351438
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CTGTCAATGAGGTCCTCAAACGGGGGAGCAAGTTTATCAAATGGGACGAG[G/A]TAAGAAGATCGCGTCCGTCTGTGATTGTTATGTGGCGTGATACTTGATCT
Long Flanking Sequence:
ACTTCCTTACTCCCCCCGTCGCTCTCTCCCTCTCTCTCTCCGTCTTTCTCGCGCTCCCATTTAGTTCGGAGAAAACATGAAGGAAAAGAGGAGCAAATTCCAGCGGGGACCAAAGCCAAGTGAAAGTTTCTCCTGAGCTGGGATCTCATCATTACTGAGCGGATGGACGGACAGGAAGGAAAATATCAATTCAAGTCCTTGCCGTGATAAGCGCTTAGATGAACAAACAATCGCCAAAGTCTTAAAGTGCGCCCGCTCGTGAATGTGTGACAGTCGCGTCCGCGTGTGTTGACCCAGGCGGACTCGAGGCGTTGGGTCAAGCTCTGGTTCCGTTGTTACACTGAAGGTCAGAAACTTCCAACCGAGAAGCTGAGGCGTCGCCACCCGTCGATTCAGCAGCCATGGCCGGGGCGAAACCGGGAGTTCACGCGTTGCAGCTCAAACCGGTGTCTGTCAATGAGGTCCTCAAACGGGGGAGCAAGTTTATCAAATGGGACGAG[G/A]TAAGAAGATCGCGTCCGTCTGTGATTGTTATGTGGCGTGATACTTGATCTGTGTTACACGTTGAAGTCATTTACAGTCAAACATCTGACACCCAGGACAGAGCTGGAGTTCAGCGCTGTTCCAAGTTTCGACTTCTTGTGCTCTGTTGATAAACACTCGACTTGTGTTTTATGTTTGCTGTTGTTTTCCCTTCATGGAACGACTTTTGAGTTGTGTAAATATTGGTTTATAATGGGGAAAACTGCCCGTTTTAAAGATACTATTTGTAAGAGCATGACATTCACGATTCGTGTCGCATATGGAACTTAACCCTTGCTAGGCTGATCTGTAGATCTGTTTTGGCAGATCATAAACACTGTTATTCAGGCCTGATTATCAGAAACATGATAATCATGACTCATGAAACCATGTTTGAGTTCGTGGCATTACTGTGTATTTTAGGGACATTAAAAGGAAAATGTAGGCTATTATCACTTTTTTTTACAAGCCATACAGTATTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa15031
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
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Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000098563 Essential Splice Site 497 1244 14 34

The following transcripts of ENSDARG00000068246 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 7 (position 60759041)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 59978006
GRCz11 7 60283243
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
AGCATCCGACGCAAGGATGGGACAGAYGAACAGTCTTCACCTTTGAATGG[T/C]GTGTGTACACATGCWAGCATACCAAAATATAACCTMATCTGCTCCAGCAC
Long Flanking Sequence:
TTTTGCCATTGTGTATATCTTACCTTGGTTGTTGTTTTCTTTTAGAGCAAAGCAGCAGGCTAAAATGGCTGAATATTGTCGCTCAATGTTTGGGGATGCGCTGCTCATTGACCCACTGGACAAATATCCGGTGGGTTGTTCATCACCATAAAACCAAATTTATCAAACTTTAGTTGTCAGAAGTTTAAGACAATCTATCAATGTAAGTATGTAAGGAGCATGATGTCCAATGAACTTGATAGTTTGCGCAAAAATATAAAATGACAGATTGATCATAACCCAGAGTAAGTAATAATTGAAAATGACAGATTGATTTGGCCTTTATCATTGAGAGATCATGTTGTTTTTCAGCTGGTTCCTGGTCAACAACTCCCAAGCCCCCAGGAGCTGTTGGGGAAGATCTTGATCAAGAACAAGAAGAAACATCACCACAGGGCCTCTAACGGTGGGAGCATCCGACGCAAGGATGGGACAGATGAACAGTCTTCACCTTTGAATGG[T/C]GTGTGTACACATGCAAGCATACCAAAATATAACCTAATCTGCTCCAGCACAGAAGTGACTGTGATTTCAATGATCACAAAATGCATCAAAACAAATGTGATGATTATTTAAATGTTTATAGCAACTTGAGAACACGCATCATACTGTGTATCTATATATGATTTGGATGTGTGCATATAGAAATTAAGTTTGCACATTGAGGTACTAGCCAAGACATGAGCACAATGGTCAAACACTTTAGTTGAGCGTGTTTACAAGGAAAAATGAAAAAAACGGTAACTGTAATCTGTGTGAATGGCTTGTTAGAATGCACATCAGTGTTTCCTACATCAGCAGATCATGTTGTGTGTTGTTGGACAGGGCAACCTGTGATGTCCAATTAGTGTATTAGGCCCTCAAGAGCCAATTCCTATAATGAATCAAGCTTCTGATGCTGATGTGATTTTTATTCTAACAGCATTCTCACTCACTGAACAGTGAACAATTCCGTCACAGTTAAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa9679
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000098563 Nonsense 726 1244 21 34

The following transcripts of ENSDARG00000068246 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 7 (position 60750769)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 59969734
GRCz11 7 60274971
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
ACACAGATCATCTCAGGCCAGTTTCTAAATGATAAGAAGGTTGGTGTTTA[T/A]GTGGAGGTGGACATGTTTGGGCTTCCTGCAGACACTAAAAGGAAATATCG
Long Flanking Sequence:
CAGATGGTGGCACTAAACTTCCAAACCCTTGGTGAGACATGAACATAGCTGTTTTGTTCTTCATGGTTTGTCTTTAGCTGTTGTGCTTCATTTTTGCATAAGAATTCCTTAAAGTAGCTTTTACTCTGTTTCTCAGACCTGGCGATGCAGCTGAACATGGGGGTGTTTGAATACAATGGCCGCTGTGGCTATCTGCTGAAACCGGAGTTCATGAGACGCACTGACAAACACTTTGACCCCTTTACTACAGACATTGTGGATGGCATTGTAGCCAATACAGTTAAAGTCAAGGTATATTATTATTATTATTTATATTATTATTATTATTATTATTATTATTATTATTATAATTATATTTACTGTTTCAAACAACAGATGATGTGCGTTATTCTGCATTTTATATTTTCACATGTAAAATGTACAGTTTGATGACATCTAATTCCTTCACATACACAGATCATCTCAGGCCAGTTTCTAAATGATAAGAAGGTTGGTGTTTA[T/A]GTGGAGGTGGACATGTTTGGGCTTCCTGCAGACACTAAAAGGAAATATCGAACAAAAACTTCAAACAACAACTCTCTGGACCCAGTCTGGGATGATGAAACCTTTGTGTTCAATAAGGTTTGAAACTAAAGTAATATTTTACCCAAAATTTGCAATTCTGTCATGCACAAGCTTATGTGTATTCTTATGTAAAATGAATTGCATTTTGAAAAAGTATGTAATTCATTTCATTCTCTGTCTAGGTGGTGTTACCTACGCTAGCATCTCTGAGAGTGGCGGTATATGAAGAAAACGGAAAGTTTATTGGTCATCGTATCTTGCCAGTGTCAGCGTTGCGCCCAGGTGCCTATACATGGCAGTAATCTCGCTAGTCTGATACAGTAACAAACGTCTACTTGCTTGCAATAACTGTTGTGTTCGGTTATATGTGTGTGTGATAGGATATCACTACATCTGTCTAAAGAATGAACTGAACCAACCACTCATGCTGCCTTCCCTGC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa41058
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000098563 Essential Splice Site 765 1244 21 34

The following transcripts of ENSDARG00000068246 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 7 (position 60750651)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 59969616
GRCz11 7 60274853
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACAACTCTCTGGACCCAGTCTGGGATGATGAAACCTTTGTGTTCAATAAG[G/A]TTTGAAACTAAAGTAATATTTTACCCAAAATTTGCAATTCTGTCATGCAC
Long Flanking Sequence:
TTTTACTCTGTTTCTCAGACCTGGCGATGCAGCTGAACATGGGGGTGTTTGAATACAATGGCCGCTGTGGCTATCTGCTGAAACCGGAGTTCATGAGACGCACTGACAAACACTTTGACCCCTTTACTACAGACATTGTGGATGGCATTGTAGCCAATACAGTTAAAGTCAAGGTATATTATTATTATTATTTATATTATTATTATTATTATTATTATTATTATTATTATAATTATATTTACTGTTTCAAACAACAGATGATGTGCGTTATTCTGCATTTTATATTTTCACATGTAAAATGTACAGTTTGATGACATCTAATTCCTTCACATACACAGATCATCTCAGGCCAGTTTCTAAATGATAAGAAGGTTGGTGTTTATGTGGAGGTGGACATGTTTGGGCTTCCTGCAGACACTAAAAGGAAATATCGAACAAAAACTTCAAACAACAACTCTCTGGACCCAGTCTGGGATGATGAAACCTTTGTGTTCAATAAG[G/A]TTTGAAACTAAAGTAATATTTTACCCAAAATTTGCAATTCTGTCATGCACAAGCTTATGTGTATTCTTATGTAAAATGAATTGCATTTTGAAAAAGTATGTAATTCATTTCATTCTCTGTCTAGGTGGTGTTACCTACGCTAGCATCTCTGAGAGTGGCGGTATATGAAGAAAACGGAAAGTTTATTGGTCATCGTATCTTGCCAGTGTCAGCGTTGCGCCCAGGTGCCTATACATGGCAGTAATCTCGCTAGTCTGATACAGTAACAAACGTCTACTTGCTTGCAATAACTGTTGTGTTCGGTTATATGTGTGTGTGATAGGATATCACTACATCTGTCTAAAGAATGAACTGAACCAACCACTCATGCTGCCTTCCCTGCTTGTGTACACTGAGGTACAGGACTACATTCCCAACGAGCACCAAGGTAGGCAAGGGATTTCAGGGATATCCAATACCATTTACATAACCTTCCCTCCTCCATCTGGCCTGCAACTGTC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa12809
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > G
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000098563 Nonsense 779 1244 22 34

The following transcripts of ENSDARG00000068246 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 7 (position 60750485)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 59969450
GRCz11 7 60274687
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
TCTGTCTAGGTGGTGTTACCTACGCTAGCATCTCTGAGAGTGGCGGTATA[T/G]GAAGAAAACGGAAAGTTTATTGGTCATCGTATCTTGCCAGTGTCAGCGTW
Long Flanking Sequence:
AGTCAAGGTATATTATTATTATTATTTATATTATTATTATTATTATTATTATTATTATTATTATAATTATATTTACTGTTTCAAACAACAGATGATGTGCGTTATTCTGCATTTTATATTTTCACATGTAAAATGTACAGTTTGATGACATCTAATTCCTTCACATACACAGATCATCTCAGGCCAGTTTCTAAATGATAAGAAGGTTGGTGTTTATGTGGAGGTGGACATGTTTGGGCTTCCTGCAGACACTAAAAGGAAATATCGAACAAAAACTTCAAACAACAACTCTCTGGACCCAGTCTGGGATGATGAAACCTTTGTGTTCAATAAGGTTTGAAACTAAAGTAATATTTTACCCAAAATTTGCAATTCTGTCATGCACAAGCTTATGTGTATTCTTATGTAAAATGAATTGCATTTTGAAAAAGTATGTAATTCATTTCATTCTCTGTCTAGGTGGTGTTACCTACGCTAGCATCTCTGAGAGTGGCGGTATA[T/G]GAAGAAAACGGAAAGTTTATTGGTCATCGTATCTTGCCAGTGTCAGCGTTGCGCCCAGGTGCCTATACATGGCAGTAATCTCGCTAGTCTGATACAGTAACAAACGTCTACTTGCTTGCAATAACTGTTGTGTTCGGTTATATGTGTGTGTGATAGGATATCACTACATCTGTCTAAAGAATGAACTGAACCAACCACTCATGCTGCCTTCCCTGCTTGTGTACACTGAGGTACAGGACTACATTCCCAACGAGCACCAAGGTAGGCAAGGGATTTCAGGGATATCCAATACCATTTACATAACCTTCCCTCCTCCATCTGGCCTGCAACTGTCAACAAAAAATAACGAGATTCAGGCCCCTAAAACGTATGTTTTTTTAAATCACTATCATCATTGTCCAGTCGCATATCCACTTGTTAAGTTGTGACGTATGGATACTGTTTTTGGGTCCAAGCCGCTACTTATTTGAATTGAAAAAATATTTGTTTATGGTTTTAGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa15264
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000098563 Nonsense 796 1244 22 34

The following transcripts of ENSDARG00000068246 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 7 (position 60750435)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 59969400
GRCz11 7 60274637
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
KGAAGAAAACGGAAAGTTTATTGGTCATCGTATCTTGCCAGTGTCAGCGT[T/A]GCGCCCAGGTGCCTATRCATGGCAGTAATCTCGCTAGTCNNNNNNNNNAA
Long Flanking Sequence:
ATTATTATTATTATAATTATATTTACTGTTTCAAACAACAGATGATGTGCGTTATTCTGCATTTTATATTTTCACATGTAAAATGTACAGTTTGATGACATCTAATTCCTTCACATACACAGATCATCTCAGGCCAGTTTCTAAATGATAAGAAGGTTGGTGTTTATGTGGAGGTGGACATGTTTGGGCTTCCTGCAGACACTAAAAGGAAATATCGAACAAAAACTTCAAACAACAACTCTCTGGACCCAGTCTGGGATGATGAAACCTTTGTGTTCAATAAGGTTTGAAACTAAAGTAATATTTTACCCAAAATTTGCAATTCTGTCATGCACAAGCTTATGTGTATTCTTATGTAAAATGAATTGCATTTTGAAAAAGTATGTAATTCATTTCATTCTCTGTCTAGGTGGTGTTACCTACGCTAGCATCTCTGAGAGTGGCGGTATATGAAGAAAACGGAAAGTTTATTGGTCATCGTATCTTGCCAGTGTCAGCGT[T/A]GCGCCCAGGTGCCTATACATGGCAGTAATCTCGCTAGTCTGATACAGTAACAAACGTCTACTTGCTTGCAATAACTGTTGTGTTCGGTTATATGTGTGTGTGATAGGATATCACTACATCTGTCTAAAGAATGAACTGAACCAACCACTCATGCTGCCTTCCCTGCTTGTGTACACTGAGGTACAGGACTACATTCCCAACGAGCACCAAGGTAGGCAAGGGATTTCAGGGATATCCAATACCATTTACATAACCTTCCCTCCTCCATCTGGCCTGCAACTGTCAACAAAAAATAACGAGATTCAGGCCCCTAAAACGTATGTTTTTTTAAATCACTATCATCATTGTCCAGTCGCATATCCACTTGTTAAGTTGTGACGTATGGATACTGTTTTTGGGTCCAAGCCGCTACTTATTTGAATTGAAAAAATATTTGTTTATGGTTTTAGTCCCATCACACATTAAAGTGTATTTTACATAAAATCATGTAAATCAACAGT
Associated Phenotype:
Not determined