Busch Lab

ZMP

clcn7

Ensembl ID:
ENSDARG00000019556
ZFIN ID:
ZDB-GENE-061103-196
Description:
H(+)/Cl(-) exchange transporter 7 [Source:RefSeq peptide;Acc:NP_001071005]
Human Orthologue:
CLCN7
Human Description:
chloride channel 7 [Source:HGNC Symbol;Acc:2025]
Mouse Orthologue:
Clcn7
Mouse Description:
chloride channel 7 Gene [Source:MGI Symbol;Acc:MGI:1347048]

Alleles

There are 7 alleles of this gene:

Allele Name Consequence Status Availability
sa2122 Essential Splice Site F2 line generated Not yet available
sa20020 Nonsense Available for shipment Available now
sa14513 Essential Splice Site Available for shipment Available now
sa40074 Nonsense Mutation detected in F1 DNA Not yet available
sa40075 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa45140 Splice Site, Nonsense Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa2122
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000103660 Essential Splice Site 61 795 3 25
ENSDART00000126533 Essential Splice Site 61 795 3 26
ENSDART00000129235 Essential Splice Site 61 795 3 26

The following transcripts of ENSDARG00000019556 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 3 (position 27818938)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 27536977
GRCz11 3 27667819
KASP Assay ID:
554-3306.1 (used for ordering genotyping assays)
KASP Sequence:
ATGACTGTATGTTGCTGTTCATTCTCAGTTTGTCTTTTCCTAAATCGCAC[A/T]GGACATTATAAGAAGTCGACCGAAGGAAATCCCTCACAACGAAAAGCTGC
Long Flanking Sequence:
AGAAGAGGTAAAAAAACAGTTTAACACCAATATAAATATATAAATGTCAAACGACAAGACTTGATGGGCAACATATTAGCTTTTAGTCCAGTCCAGGCCAAAAAGGTGGCTTCAGTTTTTTTTTTTTAGAGCTGCTGTTTCAGTACTTGCTTTGAGCTATTTGTAGTTTTTATGATTTGCATATTGTATTAACACACAAGTCTGATCTAAATCTCCTCTAAAATGGGCCATTCTTGGCAAGAGACTCAGGAAAATGGCTGACTCTTTAGTTACGTCAGCATGCATTTTGGAGAAAAAGAACTGTATTGGAAATTGCATGCAATGAATGTACTGCATTATTTGTGAGAATATGTTTCCGATTTGCTGGCCTGAGGTCACGTTTGCTCAATGCTGCAGAGAGATGCTGTAGCTAAATAAAGTGCTGTGCTATTTTGACTATGTGAGCACTGAATGACTGTATGTTGCTGTTCATTCTCAGTTTGTCTTTTCCTAAATCGCAC[A/T]GGACATTATAAGAAGTCGACCGAAGGAAATCCCTCACAACGAAAAGCTGCTGTCTCTGAAATATGAGGTAATTGAATCTACTCCTGACATTCAGTCACCCTCTTTTCATTCAATTGAGTCTCTGTTAGGGATGCCTTGGAAAAAAATGGTTGGTTATTTTGTAAATTAACTTAAAAACCACAGTGGAAATGATACTTGTGTGCTTTAATACATATAAGTATCTTTGAGGAGCTGTGTTGAATCTCACACCTTGTGCTTTCTGTGTTTCAGAGTCTTGACTATGATAACAGTGAGAATCAGTTGTTTCTGGAGGAGGAGAGACGGATGAGTCAAATGGTCAGTAAAGCTCATTAAAGAGACACTCATGTAGAGGTTTGAGATGTTCAACTGTGTTTGGAACAAGCTTAACGGTTAACTTGGATCATGTGCAGATCATAATCTGTGAAAAGTGCGTTCTGAGTTTACAGCCATAACGGTTGACAGAGGCCTACAGAATGAGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa20020
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000103660 Nonsense 119 795 5 25
ENSDART00000126533 Nonsense 119 795 5 26
ENSDART00000129235 Nonsense 119 795 5 26

The following transcripts of ENSDARG00000019556 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 3 (position 27821367)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 27539406
GRCz11 3 27670248
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACCACAGGGCTTTAGATGCCTGGAGATCACACGATGGGTGATCTGCGGTT[T/A]GATTGGTTTACTCACCGGTCTCATCGCATGCTTGATAGACATTGCTGTGG
Long Flanking Sequence:
CAGATAGTGAAACAATCGCGTTGTACACTGCTGAGCTGTGCTTTTCTGTTTCTCCAAAAACCAAAAATGCTATTTAATAATTTAAACCTCTTTTTTAGAGAGTCTACAGGAAGATAAATGCTTGGACTTTTTCTGATCTTTTGATTTGTCAAAGTGCAATAAATATGCTCAATTTACATATCAATGTGTTCAAAGGCAACAGAAAATTATTCAAGGAGCAGCAGCTTTCATTTTAGCTCTGAGAGTCACAAAACTATGCCGAACATTGTTGTGTCAGAATTAGTATTGACTTGATTCGACATCTATATGTTAAGGCTTATCAGAACTGTAGTCACTGATAAGCTGTTTCCATGTAAAGACAATTTATTCAGCATACTCGCAGAACAGGGTCTGTTTTTCTTGTTATGCTTTAGTAATTTGTGGATTAACATTTAATGCTTCTCGATCTTAACCACAGGGCTTTAGATGCCTGGAGATCACACGATGGGTGATCTGCGGTT[T/A]GATTGGTTTACTCACCGGTCTCATCGCATGCTTGATAGACATTGCTGTGGAGAACCTTGCAGGACTTAAGTACTTTGCAGTCAAACTGAGTATCCTTCCCTGTACAATCCACTGAAATAATCATTTACTCGCATGAGGGAGTCATAGAGGTGCATTTGCTCTTAATTTAATTCAATTGAGCCAATACTCTGCTGTTCTAAAACTGGTTCACACTGTAATTTCATGCATTCCGTTTACATTTTGTTATATGGACTTTTGTCTAATCAGTTATCATTGAGGCTACATGAATAATTTGGCCATAAATCAGATTGCGGACGGATCGGAAACGTTTAATCTAATTGACGTTTTATTTAATGTCATCTGTCCAATTAGTTTGTTTCAATTTGCACTCAACTAAACTAAAATGTTAGTATTACCTCTTCTTTAGAGCAGCTACAGTTATTAAAATCAGGAGCTAATTTTATGAAGCCATAAATCATATTCATGATATAATGAAAAAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa14513
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
G > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000103660 Essential Splice Site 186 795 7 25
ENSDART00000126533 Essential Splice Site 186 795 8 26
ENSDART00000129235 Essential Splice Site 186 795 7 26

The following transcripts of ENSDARG00000019556 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 3 (position 27823577)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 27541616
GRCz11 3 27672458
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
TGTAAATAATGWGGTATTTTWCTTTGAASATGATYATTTATTTTTTCACA[G/T]CCCATTGCTGCAGGAAGTGGAAWCCCTCAAATAAAATGCTATCTGAATGG
Long Flanking Sequence:
TGAATAATTGAGTTTCCATCAAAGGAAAAAGTAAGTTTTAAAGTGTCTCTAGCTCTTTCTTCCTCTTTTAACTTCAATTACAAATCAAACTTGCTTTATTGACATGTCAAATGTTACACATGTATTGCCAAAGCATTTGTGATGTTTACATGAAAACAAATTACATAGTAGTATTGATATAAAACCAAAAACAATATTTAATATCATATTAAATGATTAACATTTTAGTATTAAATGATAATTAATAACAATAAACAGTATATAAAAAAATCAACATTTTAGGATTTATTTATAACAATTTAGAATTTAGTGTGTGTATCTGTGTCTTTCTCTCTATATAAATAATGTTCAGCAATATTGATAGTTTTAGTGAATTTTTGTCCTAAATAAATGGCAGGCAAAAGAAACCTCTTTCAAAAACCTTACTGTCTAATAAGTATGTTTTTTTTTTGTAAATAATGTGGTATTTTTCTTTGAAGATGATTATTTATTTTTTCACA[G/T]CCCATTGCTGCAGGAAGTGGAATCCCTCAAATAAAATGCTATCTGAATGGAGTAAAGGTTCCTCGTGTTGTTCGGCTTAAGGTGATGTCTTTTGGTTCATATATGATGTGTGATGGTGATGTATTTTATATACAGTTAGTCAGAATTATTAGCCCTCCTGAATTATCAGCCCCTCTGTATATCATTTCCCCAATTTTTGTTTAAAGGAGAGAAGATTGTTTCAACATGTTTTTAAGCATTATAGTTTTACTAACTCATTTCTAATAACTGATTTATTTTATCTTAGCCATGATGACAGTAAATAATTTTTTACTAGACACTTCTATATAATTTCCTAGAGATGGGTTGTGGCTGGAAGGGCATCCGCTGCGTAAAAACTTGCTGGATAAGTTGGCGGTTCATTCCGCTGTGGCGACCCCAGATTAAAAAAGGGACTAAGCCGACAAGAAAATGAATGAATGACTTCTATACAACTTAAAGTTAAATTTAAAGGCTTAACT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa40074
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000103660 Nonsense 199 795 7 25
ENSDART00000126533 Nonsense 199 795 8 26
ENSDART00000129235 Nonsense 199 795 7 26

The following transcripts of ENSDARG00000019556 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 3 (position 27823619)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 27541658
GRCz11 3 27672500
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TTTTCACAGCCCATTGCTGCAGGAAGTGGAATCCCTCAAATAAAATGCTA[T/A]CTGAATGGAGTAAAGGTTCCTCGTGTTGTTCGGCTTAAGGTGATGTCTTT
Long Flanking Sequence:
GTGTCTCTAGCTCTTTCTTCCTCTTTTAACTTCAATTACAAATCAAACTTGCTTTATTGACATGTCAAATGTTACACATGTATTGCCAAAGCATTTGTGATGTTTACATGAAAACAAATTACATAGTAGTATTGATATAAAACCAAAAACAATATTTAATATCATATTAAATGATTAACATTTTAGTATTAAATGATAATTAATAACAATAAACAGTATATAAAAAAATCAACATTTTAGGATTTATTTATAACAATTTAGAATTTAGTGTGTGTATCTGTGTCTTTCTCTCTATATAAATAATGTTCAGCAATATTGATAGTTTTAGTGAATTTTTGTCCTAAATAAATGGCAGGCAAAAGAAACCTCTTTCAAAAACCTTACTGTCTAATAAGTATGTTTTTTTTTTGTAAATAATGTGGTATTTTTCTTTGAAGATGATTATTTATTTTTTCACAGCCCATTGCTGCAGGAAGTGGAATCCCTCAAATAAAATGCTA[T/A]CTGAATGGAGTAAAGGTTCCTCGTGTTGTTCGGCTTAAGGTGATGTCTTTTGGTTCATATATGATGTGTGATGGTGATGTATTTTATATACAGTTAGTCAGAATTATTAGCCCTCCTGAATTATCAGCCCCTCTGTATATCATTTCCCCAATTTTTGTTTAAAGGAGAGAAGATTGTTTCAACATGTTTTTAAGCATTATAGTTTTACTAACTCATTTCTAATAACTGATTTATTTTATCTTAGCCATGATGACAGTAAATAATTTTTTACTAGACACTTCTATATAATTTCCTAGAGATGGGTTGTGGCTGGAAGGGCATCCGCTGCGTAAAAACTTGCTGGATAAGTTGGCGGTTCATTCCGCTGTGGCGACCCCAGATTAAAAAAGGGACTAAGCCGACAAGAAAATGAATGAATGACTTCTATACAACTTAAAGTTAAATTTAAAGGCTTAACTAGATAAAGTAGGGTAATTAGACAATTCATTGTATAACGATGG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa40075
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000103660 Essential Splice Site 546 795 18 25
ENSDART00000126533 Essential Splice Site 546 795 19 26
ENSDART00000129235 Essential Splice Site 546 795 18 26

The following transcripts of ENSDARG00000019556 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 3 (position 27837749)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 27555788
GRCz11 3 27686630
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TGGGCAGACCCTGGGAAATATGCTTTGATCGGGGCTGCAGCCCAACTTGG[T/C]GAGTTGTGAGTTACAGCAGTTTTCTAGCATCATGTTAATGTCAATAAGAT
Long Flanking Sequence:
CTTCGGGATGTTGTTTTAGTTGTTCTTTTGTTGCTGCATTTGTTTGTGTCTTATTTGTTGAGTTTCTGAATTGTCTGTTTGCTTTTTTCTTTTGTTTGTGTGTTTTTGCTAGTTTTGATCTAAAACAAAAACATTGTAAATTTACTGGGACCTTTTTTTGCTTAGGAACGTACAACCCAATGACTTTGGGTGTCTTTACCCTGGCGTATTTCCTCCTGGCGGTCTGGACGTATGGTTTGACCGTGTCCGCAGGAGTCTTCATCCCATCTCTGCTTATCGGTGCAGCCTGGGGTCGACTCTTTGGGATACTTTTGTCATTCATCACTACCAGTAAATCAGTAAGTACAGCATTTTGTTTGCGTCATTCCTACTATATTTTTATAACCTTAAATAAGCTAAATAAAGAAATAAAATGAGCTGGAATATTCTGTTTTTCCAAACTCACAGATTTGGGCAGACCCTGGGAAATATGCTTTGATCGGGGCTGCAGCCCAACTTGG[T/C]GAGTTGTGAGTTACAGCAGTTTTCTAGCATCATGTTAATGTCAATAAGATATTCTTTAAAGGAAGTGCAGCAAGAATGTTGTCCTGTGGTTTATTATAGCTCTTTGAAATCCGTGAAGGAAGTAACAAAGTCGACAAATAACAAAGACTGTTTTTTTTGTATTATTCTGACAGGTGGCATTGTCCGAATGACCCTCAGTCTCACAGTTATTCTGGTAGAAGCCACTGGGAATGTGACCTATGGCTTTCCCATCATGCTTGTGCTAATGACTGCCAAGATTGTTGGGGATTATTTTGTAGAGGTGAGAAACAAAATATCTGGAATGGATGTTTTTGTAACCCTTTGAATTTCCAGTAGTTTTTGGTGTGTGTGTGTTTTTTTAAGGGAATCAAGATAAAAAGCATTAGTCATGTATGGATGTTTGTTTTTGTTCGACTGGTTTTTGTTGTTCACAGGGCCTGTATGACATCCATATTAAGCTGCAGAGTGTTCCTTTCCTC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa45140
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Splice Site, Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000103660 Splice Site, Nonsense 618 795 21 25
ENSDART00000126533 Splice Site, Nonsense 618 795 22 26
ENSDART00000129235 Splice Site, Nonsense 618 795 21 26

The following transcripts of ENSDARG00000019556 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 3 (position 27840742)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 27558781
GRCz11 3 27689623
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AAAACACTGATGTAGTGAATGTGATTTGTGTATTGCTGTGCTCTTACAGA[G/T]AGGTCATGAGTTCTCAAGTCACCTGCTTCAACAGAATAGAGAAGGTCGGA
Long Flanking Sequence:
ATCAGTGCCACTTTGACTTTATCAATCAAATAGTTGTCTAAATTATAGTTCTCTTTTTTTTGGTCTCTCACTTTCCCTCTGGTTATGTTTGCTAACCGTTGTAAAAGTGAAATAATTAAGTTTTCTCCATTCAGTTATTGAAAATAATGGTGCACATCTGTAATAACATGCACATGAGGTGATGCATTTAAATTCAGTGGCTCAATGCCAGCTATTCCTTACATAACTAGTACTAAAATAACAATGGTTGAGTGTGTCATGTTGTGAATGTTTCTCAACCATGTTCCTGGAGGACCACCATCACTGCATTTTTTGGATGTCTCCTTTATCTGTTCCACCCTTTCAGCTCTTTCAGTCTCTGCTAATGATCTGATGATCTGAATCAGGTGTGTTTGGATAAGGAGACATGGAAAATGTGCAGATCTGGTGGTCCTCCAGGAACGTGGTTGAAAAACACTGATGTAGTGAATGTGATTTGTGTATTGCTGTGCTCTTACAGA[G/T]AGGTCATGAGTTCTCAAGTCACCTGCTTCAACAGAATAGAGAAGGTCGGAACCATTGTAGATGTCCTCAGCAACACTTCCACCAATCACAATGGCTTCCCAGTGGTCACCCATGTTACTGAGATTGACGAGGTGACATGATCATGAAAATATGACATCACATCCTGTCATTCCTTATGATTTCAGTAATGATTAAACTCGACCATTGTCTTTTCACAGCCAAGCAAACTCTGTGGGCTTGTTCTCCGCTCTCAGCTCATTGTCCTTCTCAAACATAAGGTGAGAAACAGTGAATCTTTACAACATTTTTGGCATTCAATCTCATTTTATAGAATAATCTTAATAATTGAGGCCTCTGTCTCGACGTCAGGTGTTTGTGGAGAGAGCATCTTCACGTTTCAGCCAAAGGAAGCTACAGCTGAAGGACTTCAGAGACGCGTATCCACGTTTCCCTCCTATTCAGTCCATCCACGTCTCTCAGGATGAGAGGGAGTGTATGAT
Associated Phenotype:
Not determined