Busch Lab

ZMP

cacna1sa

Ensembl ID:
ENSDARG00000029457
ZFIN ID:
ZDB-GENE-090514-1
Description:
calcium channel, voltage-dependent, L type, alpha 1S subunit, a [Source:RefSeq peptide;Acc:NP_00113
Human Orthologue:
CACNA1S
Human Description:
calcium channel, voltage-dependent, L type, alpha 1S subunit [Source:HGNC Symbol;Acc:1397]
Mouse Orthologue:
Cacna1s
Mouse Description:
calcium channel, voltage-dependent, L type, alpha 1S subunit Gene [Source:MGI Symbol;Acc:MGI:88294]

Alleles

There are 9 alleles of this gene:

Allele Name Consequence Status Availability
sa3185 Nonsense F2 line generated Not yet available
sa5687 Nonsense F2 line generated Not yet available
sa43740 Nonsense Mutation detected in F1 DNA Not yet available
sa37395 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa43739 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa19275 Nonsense Mutation detected in F1 DNA Not yet available
sa8800 Nonsense Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa3185
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000105895 Nonsense 179 1777 4 44
ENSDART00000134532 None None 1439 None 37
ENSDART00000105895 Nonsense 179 1777 4 44
ENSDART00000134532 None None 1439 None 37
Genomic Location (Zv9):
Chromosome 22 (position 936613)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 939525
GRCz11 22 956423
KASP Assay ID:
554-3158.1 (used for ordering genotyping assays)
KASP Sequence:
CGCCGGTGGAGCAGAAGGGRGGATTCGACATGAAGGCGCTGCGAGCGTTC[A/T]GAGTGCTGCGGCCCCTGCGCCTCGTTTCCGGGGTCCCCAGTCAGTGACAT
Long Flanking Sequence:
TTCAGACACACTACAAAACTACACACATATAAACACACACAAACACAAACAGACACATACACACACTGCATAAATACACACACACACACACACATACATATACGCACATATAAAAATACAAACACACACACACACACACTACATAAATACACACACACACACTACATAAATACACACACATACACACACACACACTACATAAGTACACACACGCATATATACAGGCATACACATTACATAAATACATATACATACACACACAAACATGCATATAGATCCATAATTACACACACATCCATACATGCACACACACACAAACACTAGAAACAAGACAAAAACTCCAAGTAAAAAAAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTCCCAGGCTGTTCACAGTGGTGGTGGACTTCATCAACAGCATCAGCGGTGTGGAGGCGCCGGTGGAGCAGAAGGGGGGATTCGACATGAAGGCGCTGCGAGCGTTC[A/T]GAGTGCTGCGGCCCCTGCGCCTCGTTTCCGGGGTCCCCAGTCAGTGACATCACCACCTTCATTTGCATATCCGCACCAATGGTTCCATTACCACTCAAATCACACACATTGATATTTGTGAAGTTTTAATCTATCGTAAAATCAAGATTGCAAATTAGTAGGACAGTAATAAGAGTTTTAATTACCTGGTTAAAGCGTAATGTCTTCTCCAGGCCTGCAGGTGGTGATGAGCTCCATCCTCAAGTCCATGCTGCCTCTGTTCCACATCTCCCTGCTGGTTTTCTTCATGGTCACCATCTACGCTATCATCGGCCTGGAGCTTTTTAAATGCAAGATGCATAAAACATGCTACCACACCGGCACAGGTGAGAAATGGCAGACAATTTGAACTCGCATATTAGACAATATCTCATTTTCTTGTGGCGATTAATTCATATGACTTGAATTATTGAATATCGGCATATGACTTGAATTATTGAATTTTGGTATATGTCTGATAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa5687
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000105895 Nonsense 179 1777 4 44
ENSDART00000134532 None None 1439 None 37
ENSDART00000105895 Nonsense 179 1777 4 44
ENSDART00000134532 None None 1439 None 37
Genomic Location (Zv9):
Chromosome 22 (position 936613)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 939525
GRCz11 22 956423
KASP Assay ID:
554-3158.1 (used for ordering genotyping assays)
KASP Sequence:
CGCCGGTGGAGCAGAAGGGRGGATTCGACATGAAGGCGCTGCGAGCGTTC[A/T]GAGTGCTGCGGCCCCTGCGCCTCGTTTCCGGGGTCCCCAGTCAGTGACAT
Long Flanking Sequence:
TTCAGACACACTACAAAACTACACACATATAAACACACACAAACACAAACAGACACATACACACACTGCATAAATACACACACACACACACACATACATATACGCACATATAAAAATACAAACACACACACACACACACTACATAAATACACACACACACACTACATAAATACACACACATACACACACACACACTACATAAGTACACACACGCATATATACAGGCATACACATTACATAAATACATATACATACACACACAAACATGCATATAGATCCATAATTACACACACATCCATACATGCACACACACACAAACACTAGAAACAAGACAAAAACTCCAAGTAAAAAAAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTCCCAGGCTGTTCACAGTGGTGGTGGACTTCATCAACAGCATCAGCGGTGTGGAGGCGCCGGTGGAGCAGAAGGGGGGATTCGACATGAAGGCGCTGCGAGCGTTC[A/T]GAGTGCTGCGGCCCCTGCGCCTCGTTTCCGGGGTCCCCAGTCAGTGACATCACCACCTTCATTTGCATATCCGCACCAATGGTTCCATTACCACTCAAATCACACACATTGATATTTGTGAAGTTTTAATCTATCGTAAAATCAAGATTGCAAATTAGTAGGACAGTAATAAGAGTTTTAATTACCTGGTTAAAGCGTAATGTCTTCTCCAGGCCTGCAGGTGGTGATGAGCTCCATCCTCAAGTCCATGCTGCCTCTGTTCCACATCTCCCTGCTGGTTTTCTTCATGGTCACCATCTACGCTATCATCGGCCTGGAGCTTTTTAAATGCAAGATGCATAAAACATGCTACCACACCGGCACAGGTGAGAAATGGCAGACAATTTGAACTCGCATATTAGACAATATCTCATTTTCTTGTGGCGATTAATTCATATGACTTGAATTATTGAATATCGGCATATGACTTGAATTATTGAATTTTGGTATATGTCTGATAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa43740
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000105895 Nonsense 269 1777 6 44
ENSDART00000134532 Nonsense 28 1439 1 37
Genomic Location (Zv9):
Chromosome 22 (position 934276)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 937188
GRCz11 22 954086
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AGGCAGCTCCCTGTGCTCAGGCCGGTAATGGCAGGCGATGCACTCTGAAC[G/T]GAACTGAATGCCGAGGTGATTGGCCCGGACCAAATAATGGCATCACTCAC
Long Flanking Sequence:
ATAAACTTGAAGAATTAAATATCGGCATATGACATGATTTAATATCGCTATATGATTAGAGGAAATTTCGGCATATGACATGATTCAATATCGCTATATGATTAGAGGAAATTTCGGCATATGACATGAATGAATATTGGTATGTGATTAGAATGATTAACTATCGGCATATGACTACAATAATTAAATATCGGTATATGACTTGAATCATTAAATATCGGCATATGACATGAATAAATATCGGCATATGACTTGAATTATTGAATATCGGCTTATAACTAGAATGAATGAATAAAAAGACATGACATGACACGGCTAAAGACATGACTGAATATCGGCACATCTCTAATTTGAAGAACTCACAGTAGAATCCTCCAGTAAATATGAATGCAGTTATACACTCTCTGCTCTGTTCTGCCGCAGATATTATTGCCACAGGGGACGATGCTCAGGCAGCTCCCTGTGCTCAGGCCGGTAATGGCAGGCGATGCACTCTGAAC[G/T]GAACTGAATGCCGAGGTGATTGGCCCGGACCAAATAATGGCATCACTCACTTTGACAATCTGGGTTTCTCCATGCTCACGGTTTACCAGTGCATCACCACTCAGGGCTGGACGGACGTTCTGTACTGGGTCAGTAGAGCTGTGGTTCTGCTATACTTAAACCTGCTTCTCCAATACCGTACAAGCCTAGAACGGCTGATTTACACCAGAGTAATTACAGAGGCAGTATTGGGTGTAAACATATTCAGTGTAAATAGTTACTATAATTAGATGACTTTTCCACTGAAAAAGTAAAGTAAGGGATTACTTGTCATTTTTAGGTAACTTAATTATAATTACTTACAATGTACTCAAATTAAATACATATTTTTCAACTATAGCTAATTACTCTTCAGGCACTGGAAGAAAATATAAGCCCATTGCTCTGGGTTTTGGACAAAAATCATGGACACCATTTGGAGAAATAAAAAAACATTCCCTGACTTTCAATGTCTGGAATAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa37395
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000105895 Essential Splice Site 981 1777 24 44
ENSDART00000134532 Essential Splice Site 740 1439 19 37
Genomic Location (Zv9):
Chromosome 22 (position 915318)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 918230
GRCz11 22 935128
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CACAATGTTAAAGTCTCCAAATCATTCTCCTGTGCTTTGGTGACGCTCTC[A/C]GGGGAACGTTTATTCAACATCAGGAGAACGCTCTTCATGATATGGTGGTC
Long Flanking Sequence:
TTCATTCAGCATGTGGTCCAGTGTGTGTTTGTGGCCATCAAGACCATCGGCAACATCGTTTTAGTCACCATGCTCCTGGATTTCATGTTCGCCTGCATCGGCGTCCAACTTTTCAAGGTCAGGAAGTTCACACAGACACTTCAACTTAGTTATTATTTCTAGACTTAAAGAATAGTTCCACAAAATTAGTTCTATGGAGGATGAGAGAGCTCCAGGATTTCATCTAAAATATCTTTATTTTGTGTTCTGACGAGGAACGAAGCTCTCAGGGGATTGACACGACATTATGGAAAGTAATTATAACTGAATTGATCATTTTTGTGTGAACTACCCCTTTAATCTGTGTTTCGTTTTTGGCAGGGGAAATTCCTATACTGCACAGACCCGCTGAAAATGACGGCAGAGGAATGCCAGTATGGTTAAACGTTCATTGTATTTATTCTTTCACTCCACAATGTTAAAGTCTCCAAATCATTCTCCTGTGCTTTGGTGACGCTCTC[A/C]GGGGAACGTTTATTCAACATCAGGAGAACGCTCTTCATGATATGGTGGTCAGTCAACGCTTGTGGATGAACAGCGACCTGAACTTCGACAACGTTCTGAACGGCATGCTGGCTCTCTTCACCGTGTCCACATTCGAGGGATGGCCAGAGTACGCACTAGACAAACACTGTGCTCCCAGTCAGATAGTTACAAACGTGATGTGATTAGTAGGCCCACGAGGAATCTGCACGCATAGAAATCTGCACAAAATAATCTTCTGTCCAAAGGAAACACAAGATTGTTTCTCTTACTCCATTGCAAGGTTATTATAGTTAACAAAACAAACGAAAACACGTAAACTAAAATGCTAAATAATTGTCGTTAACTGAAATAAAAACGAGAGTTTAAAAAAAAAAAACTAGAACGGAAACTGTGTTGTGTACATACAAAACTAACTGAAACTAGCTCAAATTATAGCAAAAACCTCCTTCATTTTCGTCTTTGTAAATGTATTTAATGCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa43739
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000105895 Essential Splice Site 1497 1777 37 44
ENSDART00000134532 Essential Splice Site 1256 1439 32 37
Genomic Location (Zv9):
Chromosome 22 (position 901453)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 904365
GRCz11 22 921263
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CGCCACACTCTTCGCTCTGGTCAGAACGGGACTGAAGATTAAAACTGAAG[G/A]TTTGAGGTCACATTTAATTATTTTAATTAAATTCACATTTAACTAATATA
Long Flanking Sequence:
AGAAGGTTGGTTAGATAAATAGGGGAGCTATATAAGCTAAAATAGCTACAGGGGATTGTCCGTAGTGTATGTGTGTGATTGAGTGTGTATGGGTGTTTTCCAGTGATGGGTTGCAGTTGGAAGGGCATCTGCTGCATAAAACATGCTGGATAAGTTGGTTCATTCTGCTGCGGTGACCCCAGATCAATAAAGGGACTAAGCTAAAGGAAAATTAATGAATGAATTACGCAGTGCAATGATGCTCAAAACCTGCCGGAACTACTTTATGTGTTTATCTTTATCTGAAAACAACGACTCGCCTTAGAACGCTCACCAGCCAATCAGAATCAAGCATTCATTAACCATAGTAGTGTGAAAATGTTTAACCGTTTAAGGGATTTTAATGTTGTGTTTGCAGAGACTGATTTCCATGAATATGCCCTTGAACAGCGACGGAACCGTAACGTTTAACGCCACACTCTTCGCTCTGGTCAGAACGGGACTGAAGATTAAAACTGAAG[G/A]TTTGAGGTCACATTTAATTATTTTAATTAAATTCACATTTAACTAATATATACTGTTAAAATTATGCTTGGTAACCTGTACAGTAATGTTTCTTCTGTTACATACCATCAGTTAACTACTTCATACATATTATTTATTGAGTTTGGCTGGTTTGTGTTAGCAAATACAATGTTATAATGTCAACAAATGCGGTGGCACGGTGGCTCAGTGGTTAGCACTGTGGCCTCACAGCAAGAAGGTCGCTGGACAGAGTCCCAGATGGGTCAGTTGGCGTTTCTGTGTGGAGTTTGCATGTTCTCCCCGTGTTGGCGTGGGTTTCTCCACAGTCCAAACACATGCGCTATTGGGGAATTGTGTGAATGTGAGTGTGTATGGGGGTTTCCCAGTACTGTGTTGCGGCTGGAAGGGCATCCGCTGCGTAAAACATATGTTCGCTGTGGCGAACCCTGATAAATAAGGGACTAAGCTGAAGGAAAATGAATGAATGAATATTACGAAGC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa19275
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000105895 Nonsense 1649 1777 42 44
ENSDART00000134532 Nonsense 1408 1439 37 37
ENSDART00000105895 Nonsense 1649 1777 42 44
ENSDART00000134532 Nonsense 1408 1439 37 37
Genomic Location (Zv9):
Chromosome 22 (position 899148)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 902060
GRCz11 22 918958
KASP Assay ID:
2261-6206.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GAAACCGGTTATCCCATGCCTACTCACAGGTGACCAGCCAGAGACCCCTA[C/T]AGCTCGCAGATAGCAGAGCGGACAGGACGGAGACCACATACGCCAGTTAC
Long Flanking Sequence:
TCTGAGGAGCATCGAGGAGGAGGCGGCTCCTGAACTCCAGAGAGCCATTTCTGGAGACCTCCTTAATGACGAGGAGATGGACAGAGCGATGGAGGAGTCCGGAGAGGAGAGCATCTATAGGGTGGGTGCAGATCAGAGATGATGGAGTGATGGAGAAAAGCAGAGTCATCTCATTTCTCTCTCTGTTCTCCTCTTTAACAGCGTGCTGGAGGTCTGTTTGGAAACCATGTGGATCCGTTCAGCATGGAGAGAGGAACCGGGGCAGCACAGGTAGGCGTGGGCCGGTATAAGATTCTGACAGTATGATAACCTTGAATAAAATATCAGGGTATTGCAATTACTGCTCTAAAACTATATAAAGTAGCTATAAAAAAAACAAGCATATACCGTTGGAACGGTATAACAGAAAATTTCAGTCATTTTAAAACCTTGACTTTTCCAAACCGCGGTGAAACCGGTTATCCCATGCCTACTCACAGGTGACCAGCCAGAGACCCCTA[C/T]AGCTCGCAGATAGCAGAGCGGACAGGACGGAGACCACATACGCCAGTTACCATGCCAACAACAACAACACCAATAACAACAACAGACGCAGACACAGGTGAAAATAACAAAACACCAAAAACACTGATACCAACAACACCAACACAAACAACACCACTACCAACAAACACAAACAACAACACTGATACCAACAACACTGATACTAACAACACCAACACAAACAACACCACTACCAACAAACACAAACAACAACACTGATACCAACAACACTGATACCAACAACACTGATACCAACAACACCAACACAAACAACACCACTACCAACAAACACAAACAACAACACTGATACCAACAACACCAACACAAACAACACCACTACCAACAAACACAAACAACAACACTGATACCAACAACACCAACACAAACAACACCACTACCAACAAACACAAACAACAACACTGATACCAACAACACTGATACCAACAACACCAACACAAACA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa8800
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000105895 Nonsense 1649 1777 42 44
ENSDART00000134532 Nonsense 1408 1439 37 37
ENSDART00000105895 Nonsense 1649 1777 42 44
ENSDART00000134532 Nonsense 1408 1439 37 37
Genomic Location (Zv9):
Chromosome 22 (position 899148)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 902060
GRCz11 22 918958
KASP Assay ID:
2261-6206.1 (used for ordering genotyping assays)
KASP Sequence:
GAAACCRGTTATCCCATGCCTACTCACAGGTGACCAGCCAGAGACCCCTA[C/T]AGCTCGCAGAYAGCAGARCGGAMAGGASGGAGACCACATACGCCAGTTAY
Long Flanking Sequence:
TCTGAGGAGCATCGAGGAGGAGGCGGCTCCTGAACTCCAGAGAGCCATTTCTGGAGACCTCCTTAATGACGAGGAGATGGACAGAGCGATGGAGGAGTCCGGAGAGGAGAGCATCTATAGGGTGGGTGCAGATCAGAGATGATGGAGTGATGGAGAAAAGCAGAGTCATCTCATTTCTCTCTCTGTTCTCCTCTTTAACAGCGTGCTGGAGGTCTGTTTGGAAACCATGTGGATCCGTTCAGCATGGAGAGAGGAACCGGGGCAGCACAGGTAGGCGTGGGCCGGTATAAGATTCTGACAGTATGATAACCTTGAATAAAATATCAGGGTATTGCAATTACTGCTCTAAAACTATATAAAGTAGCTATAAAAAAAACAAGCATATACCGTTGGAACGGTATAACAGAAAATTTCAGTCATTTTAAAACCTTGACTTTTCCAAACCGCGGTGAAACCGGTTATCCCATGCCTACTCACAGGTGACCAGCCAGAGACCCCTA[C/T]AGCTCGCAGATAGCAGAGCGGACAGGACGGAGACCACATACGCCAGTTACCATGCCAACAACAACAACACCAATAACAACAACAGACGCAGACACAGGTGAAAATAACAAAACACCAAAAACACTGATACCAACAACACCAACACAAACAACACCACTACCAACAAACACAAACAACAACACTGATACCAACAACACTGATACTAACAACACCAACACAAACAACACCACTACCAACAAACACAAACAACAACACTGATACCAACAACACTGATACCAACAACACTGATACCAACAACACCAACACAAACAACACCACTACCAACAAACACAAACAACAACACTGATACCAACAACACCAACACAAACAACACCACTACCAACAAACACAAACAACAACACTGATACCAACAACACCAACACAAACAACACCACTACCAACAAACACAAACAACAACACTGATACCAACAACACTGATACCAACAACACCAACACAAACA
Associated Phenotype:
Not determined