Busch Lab

ZMP

tlk2

Ensembl ID:
ENSDARG00000010779
ZFIN ID:
ZDB-GENE-060623-36
Description:
Serine/threonine-protein kinase tousled-like 2 [Source:UniProtKB/Swiss-Prot;Acc:Q1ECX4]
Human Orthologue:
TLK2
Human Description:
tousled-like kinase 2 [Source:HGNC Symbol;Acc:11842]
Mouse Orthologue:
Tlk2
Mouse Description:
tousled-like kinase 2 (Arabidopsis) Gene [Source:MGI Symbol;Acc:MGI:1346023]

Alleles

There are 5 alleles of this gene:

Allele Name Consequence Status Availability
sa14440 Nonsense Available for shipment Available now
sa45138 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa26040 Nonsense Mutation detected in F1 DNA Not yet available
sa10364 Nonsense Available for shipment Available now
sa18506 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa14440
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000006490 Nonsense 124 697 7 21
ENSDART00000141937 Nonsense 124 697 6 20
Genomic Location (Zv9):
Chromosome 3 (position 19584931)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 19547966
GRCz11 3 19697706
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
TRTTGATGGTAAATAGAAATGTTTGTTTTGGTTTTGATTGACAGGWGCAG[C/T]AAGGAAGCCCCTCCTCCATCAGTTCAGTAAACACAGAYCACTCCCACACC
Long Flanking Sequence:
AACCAGTTCTGTTAAGTAAATCGATCAGCTCTCTTAGTAACACTTTGTTTGTTGTTCCTTTGTACCAAAAGTGTTACAGTTTTAAAAGTAAACATTCCAAGTGGAACCAAACATTGCACTTGCTAAGAGTAATTCGTTTATGGTGATGAGAGTTGGTAAGAAAAAAACAGTACATCGGGACACATGTAGATTGTATTAGATTATATATTGAAGTTGATGCCTTTAAACAGAGGCCAATAACCTCTTCTTACTCTAGTTTAAGTAGTTTAGTACTGACAATATAATCGTAGATTTATATTTTGTACTCACATAATGACAATAGCTACTTTAATATATTAATAATAATAATAATAAGAAGAAGAAGAACAAACATAAGAAGCAGACTGATTTGAAGTACAGAAAACTGACAGAAGTGCACAATGAGGCTCTTATCAGTGACACTTACTGTTTTGTTGATGGTAAATAGAAATGTTTGTTTTGGTTTTGATTGACAGGTGCAG[C/T]AAGGAAGCCCCTCCTCCATCAGTTCAGTAAACACAGACCACTCCCACACCTCCACCTCCCACAAGCCAGCCTCAATACACACTCAGCACCGAGCTTCACAGGTAACACACACTACCAAAAGCACTCGCAACACACAGATGCTTTCACTTTCTCACACTTAACACTCACCTTCGGTTACTGTTTCCTCAGTCTGAGCTGACTATGGAGAAATTAGCAGCGCTGGAGAGCAGTAAGAGTTCAGATCTGGAGAAGAAAGAAGGACGTATCGATGACCTGCTCAGGGTATGACTTCAATTTAGCCTATTGTCTGAAAGTTTATGTTGATTGTTTCTCATTGCTTCATGTTCAAACAGCAAATCATTTTAGGATGTTTAACTCGTATTAAGAGTAATGCTGCTGATTATTCAGCTTTGTGTGACAGGATAAAATTGTATCATATATGAGTAATTCAATGCAAATGTCAACCTTTCCATTTAAAAAAAAAAAAGGTTAATATAAAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa45138
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000006490 Essential Splice Site 225 697 9 21
ENSDART00000141937 Essential Splice Site 225 697 8 20
Genomic Location (Zv9):
Chromosome 3 (position 19589510)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 19552545
GRCz11 3 19702285
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACGCCTCAATAAATGTGTGACCATGAGTAAGAAACTGCTTATCGAAAAGG[T/C]AAACAGATTTTGCTTAGTATTGTTCTTTATGTATGCCGCATTCTTTAATT
Long Flanking Sequence:
GTAAACACAAGACACCTCCTCCATGGGACTCCACACTTGTAAACACTCGCATCAACAGGCTCTTCACACCACCCACGTGTGTCAACACTACCAAACCGACTAATCACAGAGCTAGCACCACGCGTCTTCGCAACTTGCAGTTAAATTTTTTAAGAGGTGCGTGGGTATGCGACCGCCCGAAGACTTTGCTAGACCTTCCTTAACAAAGCGGGGTCACGTGACCCCACACACAGTAGGCAAAATAATCGATAAAATCAACCTGGGAAAATTTGATCGATTATAGTTTCTGAATTTTGATTATTTTTCCATTAATAATGCTTTGCTGAATTCATTAATTTCCATTTCGTGCTTTGCTGAAGAATACAATGTTTGGGTTTGTGCACTTCAGGTGAACTGTGACCTGCGCAGACAGATCGATGAGCAGCAGAAGATGCTGGAGTGGTGTAAAGAACGCCTCAATAAATGTGTGACCATGAGTAAGAAACTGCTTATCGAAAAGG[T/C]AAACAGATTTTGCTTAGTATTGTTCTTTATGTATGCCGCATTCTTTAATTCGATATTTTTTAAAAAAATGCACAGCTATATTATTTGAAGCACTGCATTTAGTGTCTATGGGGTATGTCTTCAGTAATGTGCTAGTGTGTGTGTCTCAGTCCAAACAGGAGAAAATTGCTTGCAGAGAAAAGAGCATGCAGGACCGACTACGACTTGGTCATTTCACCACTGTACGACACGGAGCCTCATTTACAGAGCAGTGGACGGATGGATATGCGTTTCAGAATCTAGTCAAGTACGTGAGTTGCACATGCTCATGCTTTAGAGGCTAGTTAAATGCTGCATGCATGCACACTGGACAAACATTAGCCATGAAAGCCTTATTCAGGACTGTGTTCTGGTATGATGGTGAATCAATGCAGTGCATTCAGAATGTAACAGGGCGCTAACATGCACACTGACTTTCCATGGACTTTTTTTTTTTTTTTCTTTTTTTATGAAGTCAGTTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa26040
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000006490 Nonsense 243 697 10 21
ENSDART00000141937 Nonsense 243 697 9 20
Genomic Location (Zv9):
Chromosome 3 (position 19589711)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 19552746
GRCz11 3 19702486
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CCAAACAGGAGAAAATTGCTTGCAGAGAAAAGAGCATGCAGGACCGACTA[C/T]GACTTGGTCATTTCACCACTGTACGACACGGAGCCTCATTTACAGAGCAG
Long Flanking Sequence:
AACAAAGCGGGGTCACGTGACCCCACACACAGTAGGCAAAATAATCGATAAAATCAACCTGGGAAAATTTGATCGATTATAGTTTCTGAATTTTGATTATTTTTCCATTAATAATGCTTTGCTGAATTCATTAATTTCCATTTCGTGCTTTGCTGAAGAATACAATGTTTGGGTTTGTGCACTTCAGGTGAACTGTGACCTGCGCAGACAGATCGATGAGCAGCAGAAGATGCTGGAGTGGTGTAAAGAACGCCTCAATAAATGTGTGACCATGAGTAAGAAACTGCTTATCGAAAAGGTAAACAGATTTTGCTTAGTATTGTTCTTTATGTATGCCGCATTCTTTAATTCGATATTTTTTAAAAAAATGCACAGCTATATTATTTGAAGCACTGCATTTAGTGTCTATGGGGTATGTCTTCAGTAATGTGCTAGTGTGTGTGTCTCAGTCCAAACAGGAGAAAATTGCTTGCAGAGAAAAGAGCATGCAGGACCGACTA[C/T]GACTTGGTCATTTCACCACTGTACGACACGGAGCCTCATTTACAGAGCAGTGGACGGATGGATATGCGTTTCAGAATCTAGTCAAGTACGTGAGTTGCACATGCTCATGCTTTAGAGGCTAGTTAAATGCTGCATGCATGCACACTGGACAAACATTAGCCATGAAAGCCTTATTCAGGACTGTGTTCTGGTATGATGGTGAATCAATGCAGTGCATTCAGAATGTAACAGGGCGCTAACATGCACACTGACTTTCCATGGACTTTTTTTTTTTTTTTCTTTTTTTATGAAGTCAGTTTTGAAATGTTATCAAAAATAGATTCTAATGATGAGTTCACACCAAAGTGCACTTTTGCTTTACATTATTTGTGGGATGTTTTTTAGTCTTTAAAGTATTTATGCTCAAGTTTATTATTTTTACTTGTGTGAAAGAAACATAACACCATAACAAATAACACCAGTTTGTTCACGGGGTAATGCATATTAATGTCTTAAATTTC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa10364
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000006490 Nonsense 441 697 16 21
ENSDART00000141937 Nonsense 441 697 15 20
ENSDART00000006490 Nonsense 441 697 16 21
ENSDART00000141937 Nonsense 441 697 15 20
Genomic Location (Zv9):
Chromosome 3 (position 19597290)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 19560325
GRCz11 3 19710065
KASP Assay ID:
2259-3305.1 (used for ordering genotyping assays)
KASP Sequence:
TGTTACTAAAATGTTTCTTGACATGTTTTTAGGCATGCCTGTCGAGAATA[T/A]AGAATCCATAAAGAGCTGGACCATCCCAGAATAGTCAAAYTGTATGACTA
Long Flanking Sequence:
TTTAAACTTTAAAGTGAAGTACAACAGTTTTAGAAATGTTCCAATGAGCTGTTTTTACAACAGCCATAAATGCACTTGATAAAGCCGTGAAACAATGTCTTGAATTACATAATACGATTAATGCATACTTGGATTGTCTGTTTCTCTTTAAATGAAAATGAAATTTTTATGTATTGTGCACTTTCTCTTTTATTGGTGTTTTATTTATTATTTATTGTATACATTCTGATTTGTTCCTCACTTTTAATATAGGATATATTTTGGATTTAGGGTCAAATCTGACTGTACTTGCATTTAATATAAAAAGGTCACTGATCTGGTTTTTCTGTAAATGAATAAGATAAGGGTTTCAAAGATTTTTTTGTGACCTGCTATGTTTTCCCATAGCATTTCCTTACTTCACATATGATCTTTTTATTTTATTCAAGCCTTCTTGAGGTCTTTTGTTAATGTTACTAAAATGTTTCTTGACATGTTTTTAGGCATGCCTGTCGAGAATA[T/A]AGAATCCATAAAGAGCTGGACCATCCCAGAATAGTCAAACTGTATGACTACTTTTCCCTGGATACTGACTCGTGAGTGAACTTGCCCTCATGTTATTGAAAAGTGTACAATTTATACTTTTTCCCATTTCAAGACCCTCGTTTTGACCAATTTTTAGGATTTTAACTGAAATATTTTATGAACTTTTATGCATTGATGCATTTCTGTTATGTCACTGTGTAACGTGGACTGCTGAGAAAGTTGTTCTAATGCTTTGTAGATTCTGCACTGTTCTGGAGTACTGCGAGGGAAACGATCTGGATTTCTACCTGAAGCAGCACAAGTTAATGTCAGAAAAAGAGGCCCGGTCCATCATAATGCAGGTCGTCAATGCCCTCAAGTACCTAAATGAAATCCGCCCGCCGATCATCCATTACGACCTCAAACCAGGTCAGACACCAGTTGATCCACGTCCCAATGAACTCTTCTGTACAATGCTGAGCATGACAGCTAGCACCATT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa18506
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000006490 Nonsense 441 697 16 21
ENSDART00000141937 Nonsense 441 697 15 20
ENSDART00000006490 Nonsense 441 697 16 21
ENSDART00000141937 Nonsense 441 697 15 20
Genomic Location (Zv9):
Chromosome 3 (position 19597290)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 19560325
GRCz11 3 19710065
KASP Assay ID:
2259-3305.1 (used for ordering genotyping assays)
KASP Sequence:
TGTTACTAAAATGTTTCTTGACATGTTTTTAGGCATGCCTGTCGAGAATA[T/A]AGAATCCAKAAAGAGCTGGACCATCCCAGAATAGTCAAAYTGTATGACTA
Long Flanking Sequence:
TTTAAACTTTAAAGTGAAGTACAACAGTTTTAGAAATGTTCCAATGAGCTGTTTTTACAACAGCCATAAATGCACTTGATAAAGCCGTGAAACAATGTCTTGAATTACATAATACGATTAATGCATACTTGGATTGTCTGTTTCTCTTTAAATGAAAATGAAATTTTTATGTATTGTGCACTTTCTCTTTTATTGGTGTTTTATTTATTATTTATTGTATACATTCTGATTTGTTCCTCACTTTTAATATAGGATATATTTTGGATTTAGGGTCAAATCTGACTGTACTTGCATTTAATATAAAAAGGTCACTGATCTGGTTTTTCTGTAAATGAATAAGATAAGGGTTTCAAAGATTTTTTTGTGACCTGCTATGTTTTCCCATAGCATTTCCTTACTTCACATATGATCTTTTTATTTTATTCAAGCCTTCTTGAGGTCTTTTGTTAATGTTACTAAAATGTTTCTTGACATGTTTTTAGGCATGCCTGTCGAGAATA[T/A]AGAATCCATAAAGAGCTGGACCATCCCAGAATAGTCAAACTGTATGACTACTTTTCCCTGGATACTGACTCGTGAGTGAACTTGCCCTCATGTTATTGAAAAGTGTACAATTTATACTTTTTCCCATTTCAAGACCCTCGTTTTGACCAATTTTTAGGATTTTAACTGAAATATTTTATGAACTTTTATGCATTGATGCATTTCTGTTATGTCACTGTGTAACGTGGACTGCTGAGAAAGTTGTTCTAATGCTTTGTAGATTCTGCACTGTTCTGGAGTACTGCGAGGGAAACGATCTGGATTTCTACCTGAAGCAGCACAAGTTAATGTCAGAAAAAGAGGCCCGGTCCATCATAATGCAGGTCGTCAATGCCCTCAAGTACCTAAATGAAATCCGCCCGCCGATCATCCATTACGACCTCAAACCAGGTCAGACACCAGTTGATCCACGTCCCAATGAACTCTTCTGTACAATGCTGAGCATGACAGCTAGCACCATT
Associated Phenotype:
Not determined