Busch Lab

ZMP

gro1

Ensembl ID:
ENSDARG00000069006
ZFIN ID:
ZDB-GENE-990415-85
Description:
Protein groucho-1 [Source:UniProtKB/Swiss-Prot;Acc:O13168]
Human Orthologue:
TLE3
Human Description:
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) [Source:HGNC Symbol;Acc:11839]
Mouse Orthologue:
Tle3
Mouse Description:
transducin-like enhancer of split 3, homolog of Drosophila E(spl) Gene [Source:MGI Symbol;Acc:MGI:10

Alleles

There are 6 alleles of this gene:

Allele Name Consequence Status Availability
sa40939 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa40938 Nonsense Mutation detected in F1 DNA Not yet available
sa20989 Nonsense Available for shipment Available now
sa13620 Essential Splice Site Available for shipment Available now
sa17548 Nonsense Available for shipment Available now
sa34109 Nonsense Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa40939
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000100020 Essential Splice Site 99 771 None 20
ENSDART00000130553 Essential Splice Site 99 771 None 21

The following transcripts of ENSDARG00000069006 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 7 (position 35007131)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 33401471
GRCz11 7 33672621
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACGGCTAAATGCAATTCTTGCTCAAATCATGCCTTTTTTGTCACAAGAGG[T/A]AAATATTATCCACTTCCCATCTCTCTGCCATCATATCTTTTAGCCCTTGC
Long Flanking Sequence:
TTATCCCTCCTTCGCTCGCTCTCCATCTCTTGGCCAGATGGGCACCGCAGGCCTTCTGCCCACTTTGGCCTGGCAGAGCTGTGAATTTGGCCAGATCTGTTTCAGTAGCAGTGTGCTGGAGCGCCGTTTGGCTTCGTGAACAGCACACACACCATATCAACGCTCGAAGAGCCTCATGTTTATGCTGCACCAACTCATGGCAACATCAGCATAGGCAGACGTTTCTGAAGTTTTTACTTCATTAATCAGGAGTACTGGAGGTATCCCATCATGCCTCATTTAGATCTGCGGAGGCTTGATTAGAGTATTCACCAACGTGAAAGTAACGTGAGGGCATCAGAGCGCACGCTGCCGAGATTTAAGTACATTTGAGTGATTGGAAAAGAGCTGACAATTTAATAACCGCAGCGTTTGTGTGTCTGTTTTTCTTTTTCAGACTGAGATTGCCAAACGGCTAAATGCAATTCTTGCTCAAATCATGCCTTTTTTGTCACAAGAGG[T/A]AAATATTATCCACTTCCCATCTCTCTGCCATCATATCTTTTAGCCCTTGCAAGTTTTCAGTGTATTGATCTGTCTTTCCTCTTTCCTCCAGCACCAACAGCAGGTCGCACAGGCTGTTGAACGTGCTAAGCAAGTGACAATGACCGAGTTGAATGCCATCATCGGGGTACGTGGACTTCCCAATCTGCCTCTCACCGTGTGTATACCCCTCTTTCTTATTTATTTGACCTGGGCCAGGGACAAACCTGCACACATGAAGCTCAGTGTACTAATGCATTCATTCCTGGCTCCTAAATCACAATCGGATCTGTAATGCTCATAATGAAGCCAAACTAAAGTAGCCTTCCCCCACATGTGGGGTTTGAGTCAAAGGTGACACTTCAGTCATAATCCTCCACTGTAAAACCTTCAATCCAACACATATCACCTCAGCAGCTTTTAAACGGTTCAAGGGCAAATCCGTGATTGCTAGAGCCGTTTATAAACGTATTCTGGTTGGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa40938
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000100020 Nonsense 180 771 7 20
ENSDART00000130553 Nonsense 180 771 8 21

The following transcripts of ENSDARG00000069006 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 7 (position 34997270)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 33391610
GRCz11 7 33662760
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CCCCAGGCATCCCTCCAGTCACAGGCTCAGGGTCAGGTCTGCTGGCACTG[G/T]GAGCTCTGGGCAGCCAGGCACACCTGCCAGTCAAAGATGAGAAGAACCAC
Long Flanking Sequence:
CTTCTCGATTGTGTAAGATGAGTGTGTATAAATCAAGCCTGCTTGAAATTTGTAATTAGTACAGCGTTTGTGCATTTCCTGATTTGTTGTGAAAAGATGCATGCTAAGTAGTGTGGTTTCCAATAGCAGTGCATATTTGTAGAGGTCAGAATCAGAGCGAGCTGTTCCTGCCGAGCTCAAGGAGATCATGTCCTTGTGAAGAGTGTCCTGCTTTTGATCCAGTCACTAATTGAGGTGTTTGGGTGCCAATGTTCCTCTTTGTGCATCCTGTGAGAGAGGGGCTTAACCAGTCACCTTTATTTGGTGCTTGCTGTCCACGTGCCCTTTCACTCCGACCCACTTGATGTAAATGTGTGTGTTGACAGCAGCAGCAGCTCCAGGCTCAGCATCTTTCTCATGCTGCCCATGGACCACCAGTCCAGCTGCCCCCTCACCCCTCGGGGCTGCAGCCCCCAGGCATCCCTCCAGTCACAGGCTCAGGGTCAGGTCTGCTGGCACTG[G/T]GAGCTCTGGGCAGCCAGGCACACCTGCCAGTCAAAGATGAGAAGAACCACCATGACCTGGAGCACAGAGGTAACACAAACACATATGCATACATTGTCCAGAACACAAAAACTAATGAAGCTGAGCGCTCATGCTATGGTAAGAAAATCCAAAAATGCTGACTTGATGTTTTTTCTTTTTCTGTTTCTTTATCAACTTGTCACTTGGATAAAGAGCGGGAGTCTAGCACGGTGAGTTCTATGTTTTTAATTTGTTTGGGTTGTCTATTTGTGGAAATGCTACAGTTTTTGCCTTTTATTTATAATAAAATTCTGTTAAGTGCAGAATTTGTGTATTAACACCCATACAAGTTTTATATCTGTGCGTTTCAAAGTATTCTGTTTTTTTTTTTTTTAATATAAATATGAAGAACAGCTATGCTAATGCTCTGCTTTTAAAGTATTGGTACTACAGTAATGGTCAGTGTTGTGTACAGTGGTGGATCAGCATGAGTCATTTGC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa20989
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000100020 Nonsense 325 771 12 20
ENSDART00000130553 Nonsense 325 771 13 21

The following transcripts of ENSDARG00000069006 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 7 (position 34989403)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 33383743
GRCz11 7 33654893
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CCATCTCCATTCCTTCATCTCGCAGAACGACAAGTCCTCCACCCCAGGTT[T/A]GAAGTCCAACACCCCTACCCCACGCAACGACGCTCCCACCCCAGGAACCA
Long Flanking Sequence:
ACGCCCCAAACAGCCCAGCTTCCGTGGCGTCCTCTGGGAGCACCCCATCCTCCAAAGCGAAGGACCACCCACATGTAAGCATTAAAATTGAGGATGGACATTTGTGGTGTCAAGTCTTCGCAAACCCTTTTCCTCTAAGCAGCTATATGTCTGCGGCATAGATGTCAGTTTGAAGCATAACATGAATACATCAGCTGCTGTCAGACAAACAGCGGCTTGGCTGCTAGCCTCGGCTAATATCTCAATGCGCTTAGCTAGCCTCTGAGGGAACAGGAGAAAAGAGAGTGTGATTAAAGATGAGTGAGAGGATGAGGTCTCGGGGAAGGGTTCGGTCTGAAGTTTAGCTTTATCCTTCTCAGCTATAATGAGCTGTCAGTGTTTGACTGGATTAGTGCGAGCGAGCTCTCTGGATTTGAGCATTTGTGGTATGTAGCTTTAGCTCCGTTAATTCCATCTCCATTCCTTCATCTCGCAGAACGACAAGTCCTCCACCCCAGGTT[T/A]GAAGTCCAACACCCCTACCCCACGCAACGACGCTCCCACCCCAGGAACCAGCAACACCCCCGGGCTCAGGCCCCATCCCGGAAAACCACCTGGCATGGAAGCACTGAGTAAGTAGTAAATACACGGAATATAAAGATATGCAGCTATGGAAAACTTTAAGAGAATTTTGTTTTTATTCTTTAAACTTCTGATATTTAAATGTCCAGTTTGTTGCATAAAATAACACACAAGGTGACCCAAATAACCCTGATTCTCAATCCCAACAAAGCATCATTCTTACCAATTGTTAATTTTTGAAGGAAAAGAAAGTTAGAAGAAATGTTATACCCTTTTAGAATAGGGGTGCTTTACACCTAGACTTTTGTTCCGGAACCTGGCGCAGTTCCCCAGTTAGCGCGGTTTGTTTGGATATGTAATTTGCATATATGGCTATATAAAGAGAGAATTATGAGTAGGGTGTGATTTCCAAAAACCAAATTCATTTATTTAAATCATTAGAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa13620
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000100020 Essential Splice Site 660 771 17 20
ENSDART00000130553 Essential Splice Site 660 771 18 21

The following transcripts of ENSDARG00000069006 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 7 (position 34984409)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 33378749
GRCz11 7 33649899
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GGGACCTGAGAGAGGGTCGCCAGCTTCAGCAGCATGACTTCACAYCACAG[G/A]TTATCTTAATGCACACTTATACACCTYAAAAATGCACTTGTAATKGAAAT
Long Flanking Sequence:
ATAACTATATCCGTTCCTGTAAGCTGCTTCCGGATGGCCGTACTCTGATTGTTGGAGGGGAAGCCAGCACTCTGACCATATGGGATTTGGCCTCTCAGACTCCTCGTATCAAAGCAGAGCTCACCTCTTCTGCCCCGGCTTGTTATGCGCTGGCGATCAGCCCTGATGCCAAGGTCTGCTTCTCCTGCTGCAGTGATGGAAATATTGCCGTCTGGGACCTTCATAACCAAACCCTTGTGAGGTAGGAATCAAATGGGTGTTGCCATGTGCAAAAATTGTCTCTGCGATGTATGCAAACGTATGTGTGTTCTGCTAATGCAATAAAAGACTGCATGATTGTTTGTGTTTGTAGGCAGTTCCAGGGTCACACAGATGGGGCGAGTTGTATAGATATTTCCCATGATGGCACCAAACTGTGGACAGGTGGACTGGACAACACTGTACGGTCCTGGGACCTGAGAGAGGGTCGCCAGCTTCAGCAGCATGACTTCACATCACAG[G/A]TTATCTTAATGCACACTTATACACCTTAAAAATGCACTTGTAATTGAAATTGTAGCACAAGTATGTGGAAAAACTTTGATAATAAATGGGTGAAATAGTTTTAAATATTTATCCACGATTTAGGGTTTTCATCTTGAGTGAGTTTCTTTTAAAGTCTTGTTATTCCTTATTCCTTATTATCTTGTTAATCCTTATTCAATGTCATTAAATAAAAATAAATAAATAAGCTTTAAAATTAGTCATGGATGAAAATTGTGCAGTTTGTAAACTTTCACATCTTATCTGCACTTCACGATGAAAGATGAAGAGACTCATTCACAGCTTCAGTGCTTTATGACAGGTTTTGTGTGAAAATGCATGACTTGTCATGAACTGACATGTTAGCCGCAATATGACTTTTTTAATTTTGAATCATCAACAGCCACCAGCAAAACCCAATTTTTTGGTTATAATAAACACTCCACAAGCTTCATGCTTTAGATGGGCATGTGGCATTTGTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa17548
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000100020 Nonsense 701 771 18 20
ENSDART00000130553 Nonsense 701 771 19 21

The following transcripts of ENSDARG00000069006 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 7 (position 34983762)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 33378102
GRCz11 7 33649252
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
CTTCATCACACCAAGCCTGACAAGTACCAGCTGCACCTGCACGAGAGCTG[T/A]GTCCTCTCCCTCAAATTTGCYTACTGTGGTAAGACGCTGTTACTTTACCT
Long Flanking Sequence:
TTTTAAAGTCTTGTTATTCCTTATTCCTTATTATCTTGTTAATCCTTATTCAATGTCATTAAATAAAAATAAATAAATAAGCTTTAAAATTAGTCATGGATGAAAATTGTGCAGTTTGTAAACTTTCACATCTTATCTGCACTTCACGATGAAAGATGAAGAGACTCATTCACAGCTTCAGTGCTTTATGACAGGTTTTGTGTGAAAATGCATGACTTGTCATGAACTGACATGTTAGCCGCAATATGACTTTTTTAATTTTGAATCATCAACAGCCACCAGCAAAACCCAATTTTTTGGTTATAATAAACACTCCACAAGCTTCATGCTTTAGATGGGCATGTGGCATTTGTTCATTTATTTATTTTTTTGTCTTAGATCTTCTCTCTGGGCTACTGTCCGACGGGCGAGTGGCTGGCTGTGGGAATGGAGAGCAGTAATGTGGAGGTGCTTCATCACACCAAGCCTGACAAGTACCAGCTGCACCTGCACGAGAGCTG[T/A]GTCCTCTCCCTCAAATTTGCTTACTGTGGTAAGACGCTGTTACTTTACCTTACATAAAGTGCAACATCTTGCACCTGAGAATAAATGAGGGAAGAAACCTTATACTTAATGTAAAATAGGGCCAAAACATGACATACAAACTTCAGCTTTAGCTTTGTATTCAGTGGTGTTTTTCCATTTTAGTTTGGCAAGGTTGCACTTTGTACACCCCCCCCCCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTTAATGGCTCACTTTACTTCCAAAAAAGTCGAGTTGTAGTGAATCAAGTCATTCAGATCAACCTTGACTCTGTACCCATTAGTGCATATGTGTTTGTTCCATTTCCTAAAGGTAAATGGTTTGTGAGCACTGGGAAGGACAATCTCTTGAATGCCTGGAGGACTCCCTATGGTGCCAGCATTTTCCAGGTATGTCAGTCAATACTGTATTCCCTCTC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa34109
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000100020 Nonsense 767 771 20 20
ENSDART00000130553 Nonsense 767 771 21 21

The following transcripts of ENSDARG00000069006 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 7 (position 34981632)
Other Location(s):
Assembly Chromosome Position
GRCz10 7 33375972
GRCz11 7 33647122
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GATGATAAGTACATTGTGACGGGATCTGGTGACAAGAAGGCCACGGTGTA[T/A]GAAGTCATCTACTAAACTCGCTGCTTCACCAGAACTAAAGACCTATGGAT
Long Flanking Sequence:
CTAAAACACCTGACTATTTCAGTATTAGTGTTATTATATTATTAATTACCTCCAGAATAGACAAGAGCATCTGTGCTCTGCATCTCACTCTTTCAAACGCCATGGCACTTTCAGTGCGTGTCGACATATTCTTCTTCATTGTGCAAGTCATTTATTAAATAAGGAAAAGATTGATGCGGCTTCTCCTACCACAGCAAATTCCGTTTTTACTGTTGATATTTGGTGCCAGTTTATCAGGAAGTGATGATTTTGTTCTCTTTGCCTCGTTGGATGGAAATGCTGCCTTATTCACATGTCTTTTATGCGATTATTCCAGTTTTGTGCATTAAGTTAATCAGCATTTTTTATTTAAAACATATACAGTTTATAATGTCAGCTAATCATTTTTCATCTTTCTTCCATCTACAGTCCAAGGAGTCGTCCTCTGTCCTGAGCTGTGACATCTCGGCTGATGATAAGTACATTGTGACGGGATCTGGTGACAAGAAGGCCACGGTGTA[T/A]GAAGTCATCTACTAAACTCGCTGCTTCACCAGAACTAAAGACCTATGGATGGGCCTGATTTGTTTTGATGGATTTAAGGGATCACTCATCCACCTGTACAGTAGGAACCCAGGTTAGGAATCGGTTGGTTCACTGGGATTGCAGCCCAGATGCTTTTTTATTTTGATCGCACCTGGATTCTTACAGCAGTGAAATGATCCTCAACAAATCCACATGGAAACGTGTTAAACTGTCCCAAGGACTCCCTGACGGCACTAATGTAGTAAATATTGTCTTGCCTTTGCTTTCGGTCTGCTCATGGGATTGTGTGTGCCTATTCCTTCCATAGTATTCCCCCCCCAACCGCCTTCCTTTTAACCAACAGTGAATGATCTGTGATGTAATATGAAGCAGTGCTTCAGTTTTAGCCTCCTGCTCCCTGGACAATTTGTTAAAAAGTGTATATATGGAGTAATAAAGACATTTTATAAATATATATAATTATATATATTTCCATGTCC
Associated Phenotype:
Not determined