Busch Lab

ZMP

gro2

Ensembl ID:
ENSDARG00000002787
ZFIN ID:
ZDB-GENE-990415-86
Description:
Protein groucho-2 [Source:UniProtKB/Swiss-Prot;Acc:O13166]
Human Orthologue:
TLE3
Human Description:
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) [Source:HGNC Symbol;Acc:11839]
Mouse Orthologue:
Tle3
Mouse Description:
transducin-like enhancer of split 3, homolog of Drosophila E(spl) Gene [Source:MGI Symbol;Acc:MGI:10

Alleles

There are 7 alleles of this gene:

Allele Name Consequence Status Availability
sa9860 Nonsense Available for shipment Available now
sa9885 Nonsense Available for shipment Available now
sa23286 Nonsense Available for shipment Available now
sa18545 Nonsense Available for shipment Available now
sa16926 Essential Splice Site Available for shipment Available now
sa14607 Essential Splice Site Available for shipment Available now

Mutation Details

Allele Name:
sa9860
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
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Mutation:
T > G
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025018 Nonsense 40 776 2 20
ENSDART00000045679 Nonsense 40 776 3 21
ENSDART00000100632 Nonsense 40 759 2 19
ENSDART00000100633 Nonsense 40 762 2 20
ENSDART00000025018 Nonsense 40 776 2 20
ENSDART00000045679 Nonsense 40 776 3 21
ENSDART00000100632 Nonsense 40 759 2 19
ENSDART00000100633 Nonsense 40 762 2 20
Genomic Location (Zv9):
Chromosome 18 (position 20008327)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 20238550
GRCz11 18 20227616
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GAGTCCTGTGACAGGATCAAAGACGAATTTCAGTTCCTGCAAGCCCAATA[T/G]CACAGGTAATAATTTAGAGTTATGTGGCYGTAAAGTAGCTTGTACAATTA
Long Flanking Sequence:
TGTTCGATAGTCTGTGTTTTCATGTCTTTCCATGAGCACCTGGTTTAGAGAGACTGAAAACAACAGCATTTTTACAGTTGCAGTTTGGCACGCTCAGACCCATCCAAGCGAGGCGACCCCATTTCTCCCGCCGGTGTTTATGTGAGGCACTAAAACGGCGGACCCAGAACTGTAAAGATCCTCTCCCCCCCCCGCCTCTTTTGTCAGGACGCTACTGGTGCTCCAGCTATCTCCCAGATGTCACTGTAGCGTGGATGTCACCCCAGCCCTCATTCAGGCTGAAATATTAGAGCTGCTCTCCCAGGGCCCAGAATGCATTAGAGCCTCGCTCTGCAGTCGGTGGAAAACAAATTTGGTTCTCTGAGGATGTAATTGAGTTTGATTGATGTGATGGCTGTCTTTCAGGCGCCCCACCAGCCTGGTCAGCCAGGCTTCAAATTCACAGTGGCGGAGTCCTGTGACAGGATCAAAGACGAATTTCAGTTCCTGCAAGCCCAATA[T/G]CACAGGTAATAATTTAGAGTTATGTGGCCGTAAAGTAGCTTGTACAATTACTGCTTACCCTAATTGTGTTTCACAAGCAAAAGGGAGGAACAATCTATTTGATTCACACAAAATGTTTTCTGTAAGTAAAAAAATATATATATGGTAAAGCTGCAACATCATACAGCGTATCGGCACCTTATTGGTGCAAAGCTAATGTTGTAAACACAATTTTAGGCATAATTAGAGTTTATTTGTCTGTTTTCAAATGTATAAACAGTGTTTTCTTAGATAAAGATCTTATTCTTTTCATCTAGCAATGTTTTTTCTATAGTATATTTCAGAGGACATCATGTCTGAATTCACTTTAATATTTTTAAATATCACAGAACATTTGGTGATTTGAAATTGACATATCTTTTCATTTATTGTTTGTTCTCATTAAGATTTTGTGAAAATGTAATTATTTCATGTAAAAAAAAGTGCTTTATTGATGTAGTGTTGAATAAATGAGGTAGGGG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa9885
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > G
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025018 Nonsense 40 776 2 20
ENSDART00000045679 Nonsense 40 776 3 21
ENSDART00000100632 Nonsense 40 759 2 19
ENSDART00000100633 Nonsense 40 762 2 20
ENSDART00000025018 Nonsense 40 776 2 20
ENSDART00000045679 Nonsense 40 776 3 21
ENSDART00000100632 Nonsense 40 759 2 19
ENSDART00000100633 Nonsense 40 762 2 20
Genomic Location (Zv9):
Chromosome 18 (position 20008327)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 20238550
GRCz11 18 20227616
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GAGTCCTGTGACAGGATCAAAGACGAATTTCAGTTCCTGCAAGCCCAATA[T/G]CACAGGTAATAATTTAGAGTTATGTGGCYGTAAAGTAGCTTGTACAATTA
Long Flanking Sequence:
TGTTCGATAGTCTGTGTTTTCATGTCTTTCCATGAGCACCTGGTTTAGAGAGACTGAAAACAACAGCATTTTTACAGTTGCAGTTTGGCACGCTCAGACCCATCCAAGCGAGGCGACCCCATTTCTCCCGCCGGTGTTTATGTGAGGCACTAAAACGGCGGACCCAGAACTGTAAAGATCCTCTCCCCCCCCCGCCTCTTTTGTCAGGACGCTACTGGTGCTCCAGCTATCTCCCAGATGTCACTGTAGCGTGGATGTCACCCCAGCCCTCATTCAGGCTGAAATATTAGAGCTGCTCTCCCAGGGCCCAGAATGCATTAGAGCCTCGCTCTGCAGTCGGTGGAAAACAAATTTGGTTCTCTGAGGATGTAATTGAGTTTGATTGATGTGATGGCTGTCTTTCAGGCGCCCCACCAGCCTGGTCAGCCAGGCTTCAAATTCACAGTGGCGGAGTCCTGTGACAGGATCAAAGACGAATTTCAGTTCCTGCAAGCCCAATA[T/G]CACAGGTAATAATTTAGAGTTATGTGGCCGTAAAGTAGCTTGTACAATTACTGCTTACCCTAATTGTGTTTCACAAGCAAAAGGGAGGAACAATCTATTTGATTCACACAAAATGTTTTCTGTAAGTAAAAAAATATATATATGGTAAAGCTGCAACATCATACAGCGTATCGGCACCTTATTGGTGCAAAGCTAATGTTGTAAACACAATTTTAGGCATAATTAGAGTTTATTTGTCTGTTTTCAAATGTATAAACAGTGTTTTCTTAGATAAAGATCTTATTCTTTTCATCTAGCAATGTTTTTTCTATAGTATATTTCAGAGGACATCATGTCTGAATTCACTTTAATATTTTTAAATATCACAGAACATTTGGTGATTTGAAATTGACATATCTTTTCATTTATTGTTTGTTCTCATTAAGATTTTGTGAAAATGTAATTATTTCATGTAAAAAAAAGTGCTTTATTGATGTAGTGTTGAATAAATGAGGTAGGGG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa23286
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025018 Nonsense 241 776 9 20
ENSDART00000045679 Nonsense 241 776 10 21
ENSDART00000100632 Nonsense 224 759 8 19
ENSDART00000100633 Nonsense 227 762 9 20
Genomic Location (Zv9):
Chromosome 18 (position 20029329)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 20259552
GRCz11 18 20248618
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TCAGACAGCCTGCGCACAACCAGTGAGAAGCACCGTGGCTCCTCCGATTA[C/A]AGCTTAGACTCCAAAAAACGCAAAGTGGAGGACAAGGACAGCATGAGTCG
Long Flanking Sequence:
TTGGGGTTTTGAGTCGGATAGCTGGAATGGATAAATCGCCTTTGGCTTTTTAAGTGTGCGGTTTTGGAGTGATAAGAGCTATTCTGTCCTCTTTTTTTCCCCTCCTCGCTCTTGATTTCCCAGCCTGGATCTCCTTCCGATCCGACAACTGTGAAGTACCTGTCATTTTAATGGTAATTGTTTTTGACTCTGAACCCAAATTTATTTGTCACTACCTCAAACCAGAAATACCCTGGAACCATGTTCGGATATTAATATCTTGTGCTGAAAGAGGTTGATGGGGTCTATGGGGTATTTTAAAAGCAATTTGGCTTTTTGTTGTGGAACCAAACAAATTGAAAACCACCCAAAGATCTAAATCTACAAATGAATGAGTTGTGTTAAAGTAGTCTGATGGCACATATTTATACTTCTCCTCTTTCTCTCTTTCAGAACAACTCCATCTCTCCATCAGACAGCCTGCGCACAACCAGTGAGAAGCACCGTGGCTCCTCCGATTA[C/A]AGCTTAGACTCCAAAAAACGCAAAGTGGAGGACAAGGACAGCATGAGTCGATATGTGAGTGATGTTAACTTACATTAAAGATTTTGTAGCAAAATGCTCTGAATGCTAACTAGCTGACTTTCCATGTTTTCAGGACAGTGATGGAGACAAAAGTGATGATTTGGTGGTTGATGTTTCCAATGAGGTGAGAATAATCACGTTTGGACTGATGATGTTGAATCCATGAAATGTGTCGTCATTCTTTATTTATGTAGACTTCGATGTTTATCTTGATGTATTTTATTTTCTAGGACCCTGCCACGCCCAGAGGCAGCCCCGCCCACTCGCCGCCAGAGAATGGTATAGATAAGCCCCGGCCAGCAAAAAAGGACACACCCAACAGTCCCGCCTCTGTGGCCTCGTCTGGCAGTACCCCTTCCTCTAAAAACAAGGAGCACGGCCATGTACGGAACACTTTTTCATACACAAGCTGGCTTCATTTAATTCCGCATGCTGCATTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa18545
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
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Mutation:
C > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025018 Nonsense 381 776 13 20
ENSDART00000045679 Nonsense 381 776 14 21
ENSDART00000100632 Nonsense 364 759 12 19
ENSDART00000100633 Nonsense 367 762 13 20
Genomic Location (Zv9):
Chromosome 18 (position 20030879)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 20261102
GRCz11 18 20250168
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
YGTGTCTATGTGTCTGCAGCCGCCCCTGCTCTGCGCACCCCTCTCACTTA[C/A]CCAACTCCCTTCGCCATGATGAGCCACCATGAGATGAATGGTTCTCTGAC
Long Flanking Sequence:
CTCTCTCTATTCTCTCGTATCTGCAGAATGACAAATCTTCCACGCCTGGTCTCAAGTCTAACACCCCTACACCTCGTAACGATGCCCCCACACCAGGTACCAGCACCACCCCTGGGCTGCGGCCCATCCTGGGCAAGCCTCCGATGGAAGCTCTTGGTGAGTTTGTAATTAACGTCCACAGAGATGTTGTTTGGCTATCACTTCCTGCAAGTGTGCAACACAAACACAGCCAATACTGTAACCAAAAGAGACTTCTTTGCATATTGTAATAATCCAAAGCTTCAGCAAATTTTTAAGGCTTGCCTTTTTAACAGAGCTTAAAGTAGCTTTCATAAAACTGGTCTTTGAAGCAGCTCAGTGTAGGCAGGTCTTTGATTGAGATTTATCTCCCTGCTCCCGAGTTCAGCTCCTTTTGCCTGTGGTTGACTGATGCTGATTTATGATTGGCTGTGTGTCTATGTGTCTGCAGCCGCCCCTGCTCTGCGCACCCCTCTCACTTA[C/A]CCAACTCCCTTCGCCATGATGAGCCACCATGAGATGAATGGTTCTCTGACCAACCCTGGAGTCTATGCTGGCCTTCACATCTCTCCTCAGATGAGCGCGGCTGCTGCTGCTGCCTACGGGCGCTCGCCCATGGTGAGTAATTGTGCGTTTGTGTTAAATAAGCACCTTAGTGAAAGAGCTGCTGTTAAAACATTATTTACTTGCATATCTTGAACTTGGACCTTTCTGGAAACATTAAAAACAGAAACTTTATAATATTTTTGTTCTCGTGCACATCCACACAAAACAACTATTTGATATTATGTGGAAATACTGTTCTGAAATCTAAAATTTTATGTACCTGCTTATTCTGTTTGATTGCAGAACAGATACGTATACTTTTTTTTTTTTCGGAATTAGGCCAGGGGGGTACCTTATCTTAAAGATTTGTGCCAGAAAATTGAGATGTATTAAGGATTATTTTGGAATCAGATTGTAACTCTGAAACAAAATCGAATCAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa16926
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
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Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025018 Essential Splice Site 425 776 13 20
ENSDART00000045679 Essential Splice Site 425 776 14 21
ENSDART00000100632 Essential Splice Site 408 759 12 19
ENSDART00000100633 Essential Splice Site 411 762 13 20
ENSDART00000025018 Essential Splice Site 425 776 13 20
ENSDART00000045679 Essential Splice Site 425 776 14 21
ENSDART00000100632 Essential Splice Site 408 759 12 19
ENSDART00000100633 Essential Splice Site 411 762 13 20
Genomic Location (Zv9):
Chromosome 18 (position 20031013)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 20261236
GRCz11 18 20250302
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
WCCTCAGATGAGCGCSGCTGCTGCTGCTGCCTACGGGCGCTCGCCCATGG[T/C]GAGTAATTGTGCGWTTKTGTTAAATAAGCACMTTAGTGRAAGAGCTGYTG
Long Flanking Sequence:
AAGCCTCCGATGGAAGCTCTTGGTGAGTTTGTAATTAACGTCCACAGAGATGTTGTTTGGCTATCACTTCCTGCAAGTGTGCAACACAAACACAGCCAATACTGTAACCAAAAGAGACTTCTTTGCATATTGTAATAATCCAAAGCTTCAGCAAATTTTTAAGGCTTGCCTTTTTAACAGAGCTTAAAGTAGCTTTCATAAAACTGGTCTTTGAAGCAGCTCAGTGTAGGCAGGTCTTTGATTGAGATTTATCTCCCTGCTCCCGAGTTCAGCTCCTTTTGCCTGTGGTTGACTGATGCTGATTTATGATTGGCTGTGTGTCTATGTGTCTGCAGCCGCCCCTGCTCTGCGCACCCCTCTCACTTACCCAACTCCCTTCGCCATGATGAGCCACCATGAGATGAATGGTTCTCTGACCAACCCTGGAGTCTATGCTGGCCTTCACATCTCTCCTCAGATGAGCGCGGCTGCTGCTGCTGCCTACGGGCGCTCGCCCATGG[T/C]GAGTAATTGTGCGTTTGTGTTAAATAAGCACCTTAGTGAAAGAGCTGCTGTTAAAACATTATTTACTTGCATATCTTGAACTTGGACCTTTCTGGAAACATTAAAAACAGAAACTTTATAATATTTTTGTTCTCGTGCACATCCACACAAAACAACTATTTGATATTATGTGGAAATACTGTTCTGAAATCTAAAATTTTATGTACCTGCTTATTCTGTTTGATTGCAGAACAGATACGTATACTTTTTTTTTTTTCGGAATTAGGCCAGGGGGGTACCTTATCTTAAAGATTTGTGCCAGAAAATTGAGATGTATTAAGGATTATTTTGGAATCAGATTGTAACTCTGAAACAAAATCGAATCAAATCCTGTGGTGCCTAAAGATTCCTACTCTCTACTCCAAAGTAGGCCTCACCTTACCTTTCTCTCCCAATTTCTTCCTCTCATTTCTTTTTATTTTCTTGCTCGATTTCAATCTTACTCTCTCACCCAAAGCCCC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa14607
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025018 Essential Splice Site 665 776 17 20
ENSDART00000045679 Essential Splice Site 665 776 18 21
ENSDART00000100632 Essential Splice Site 648 759 16 19
ENSDART00000100633 Essential Splice Site 651 762 17 20
Genomic Location (Zv9):
Chromosome 18 (position 20035446)
Other Location(s):
Assembly Chromosome Position
GRCz10 18 20265669
GRCz11 18 20254735
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GGGACCTCAGGGAGGGAAGGCAACTCCAACAGCACGACTTCACATCTCAG[G/A]TTAGAAGWTARAGCATGGATTTTTWAAATTTATGTTCCACMTTATTATTT
Long Flanking Sequence:
AACCGTTTATTTGCCCTTTACAGAATAGAGACAACTACATTCGATCCTGTAAGCTGTTGCCTGATGGTCGCACACTCATTGTTGGAGGAGAGGCCAGCACTCTGACCATTTGGGATCTTGCCTCCCAGACACCCCGAATCAAAGCCGAGCTGACCTCCTCTGCGCCAGCCTGCTACGCGCTGGCCATCAGCCCAGATGCCAAGGTGTGCTTCTCCTGCTGTAGTGATGGAAACATCGCTGTCTGGGACCTTCACAACCAGACCCTTGTCAGGTGGGATTATTTCAGAGGTTTTGCATTTCATTATACATCTTTGAGGCCATTCTCTAAACCACTTTTTGGGTGAATTTTCAGGCAATTCCAAGGCCACACAGATGGTGCCAGCTGCATTGACATCTCTCATGATGGCACCAAGCTCTGGACAGGTGGTCTTGATAACACAGTCCGCTCCTGGGACCTCAGGGAGGGAAGGCAACTCCAACAGCACGACTTCACATCTCAG[G/A]TTAGAAGATAAAGCATGGATTTTTTAAATTTATGTTCCACATTATTATTTTTTGGTTGTTATTGGGGATTTGGTTGTGCACAATGTGAGCTTTGAAATGCAATTCCTAAACCATGCAAGCCAGTGATGGAGTCATATAAAGTTTAATTTAGAGGGACCTTTGATGGCCATAAGGACTTTGGAGATGCCACTGTGCAAGTGATATCGTACACGGAGTCTGTCTTTCTGTACTCCCTTGTGAAGTTCAAAGTGGTAGTCTGAAACCTGAAAATACTAATCAAATATCACCCCAATTATTATATGTTAAGCCTTTATGCATGATTCTTTAGTTATTTGTTTTAAAAATAAGAATTAGACGTATGTTTTTCATGCATTAAGAAAATCAAGTTGGTTCATGCCAGCTTTTTTGCAAAGGCACGATGTTCAGCTTGTCTACGTTTTCCCCTGTGCAGATCTTCTCTCTGGGCTACTGTCCAACGGGCGAGTGGCTGGCTGTTGGTA
Associated Phenotype:
Not determined