Busch Lab

ZMP

mdm2

Ensembl ID:
ENSDARG00000033443
ZFIN ID:
ZDB-GENE-990415-153
Description:
E3 ubiquitin-protein ligase Mdm2 [Source:UniProtKB/Swiss-Prot;Acc:O42354]
Human Orthologue:
MDM2
Human Description:
Mdm2 p53 binding protein homolog (mouse) [Source:HGNC Symbol;Acc:6973]
Mouse Orthologue:
Mdm2
Mouse Description:
transformed mouse 3T3 cell double minute 2 Gene [Source:MGI Symbol;Acc:MGI:96952]

Alleles

There are 4 alleles of this gene:

Allele Name Consequence Status Availability
sa20278 Nonsense Available for shipment Available now
sa14240 Nonsense Available for shipment Available now
sa26298 Splice Site Mutation detected in F1 DNA Not yet available
sa16808 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa20278
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000040435 Nonsense 255 445 9 14
ENSDART00000077854 Nonsense 255 475 10 11
ENSDART00000122675 Nonsense 255 475 9 10
ENSDART00000139543 None None 159 None 8

The following transcripts of ENSDARG00000033443 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 4 (position 22068649)
Other Location(s):
Assembly Chromosome Position
GRCz10 4 23411984
GRCz11 4 23132959
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TTTAACAATTCTCAACTCAGCTTTTTTTTTTTTTGCTTATTCAGATATAT[G/T]AAGTCACAATCTTCGCAGAAGACGAAGACTCTTTTGATGAAGATACTGAG
Long Flanking Sequence:
GGAAGAGGCATAAGTCGGACAGCTTTTCCCTGACATTTGATGACAGCCTGTCTTGGTGCGTGATTGGTGGCCTGCACCGGGAGAGGGGGAACAGCGAGTCTTCGGATGCAAACAGCAACTCGGTGAGGAGGACTTTTAAAATGTTTGTTCACATAGTTTTGGATTATTAACATAAGTCAGCAACTTTGTGCTGTTCTGTAGCTCTTTCTAACCAATGTTTTGCTTGTTCTACAGGATGTAGGTATATCTCGCAGTGAGGGCAGTGAGGAGAGCGAAGACTCAGACTCTGATTCTGATAACTTTAGTGTGGAGTTTGAGGTGGAGTCCATCAACTCTGATGCTTACAGTGAGAATGATGTGGATTCTGTCCCAGGAGAGAACGAGGTTTCAGCTCTTAAGTCCTGCTTTATTAAGAGAAAGTGATTAACTGATGACTACTAGTCTAACCTGTTTAACAATTCTCAACTCAGCTTTTTTTTTTTTTGCTTATTCAGATATAT[G/T]AAGTCACAATCTTCGCAGAAGACGAAGACTCTTTTGATGAAGATACTGAGATAACCGAGGCAGTATGTAGCATTTTACTTCTAAATCCTGACATTTTCCTCGAACTGGGCTTGATTTTGTATATGAGGATTATATTGGATCATGAAAAGTGTGTTAGTTTAAAGGTTAGGAATGAAAGCCTTTGTGAGTCGGCCAAAAAAAGCAGCTGTTTGAGTTTTGCAGCAAGTTATTACATTTTGTTGAAAGATTGTGATGACAGACTTTCTACTGAACTTTGTGCACTGATGGACTGTGCTTATTGTGACTAGGAATGTGTATAGAGTGCATTAGTGCCCATCCACATTTTTAGCATTTTGGCATTGTTTTTGTTTATTTGCAGGGATTCACAGGGACCAAACTAACTATTAATGAGGTAAATCACAATGTTATAAAACTGAAATGTAGGCTTCTGACAGTGTCTAATTTTCTTGTTGAGGTTAATTGCTAAAGTTTTTATCACA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa14240
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000040435 Nonsense 320 445 10 14
ENSDART00000077854 Nonsense 320 475 11 11
ENSDART00000122675 Nonsense 320 475 10 10
ENSDART00000139543 None None 159 None 8

The following transcripts of ENSDARG00000033443 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 4 (position 22070043)
Other Location(s):
Assembly Chromosome Position
GRCz10 4 23413378
GRCz11 4 23134353
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
ATTGGCTTCCAGAAACACACTCCAACTGGGAAAACCTTTCAAGAAATACT[C/T]GAACCAAYCCCGAAGACACCAGCGTCACCACAAYTCCCAACACAACCTTC
Long Flanking Sequence:
AGAGCAGTGTTTTTCAACCATGTTCCGGTAGGACCACCAGCACTGCACATTTTCTTGTCTCCAAAACCAAACACGCCTGATTCAGATCATCAGCTCATTAGCAGAGACTGAAAGACCTGTAACATGTAGTGTTAGTGGTCCTTCAGGAATGTGGTTGAGAAACACTGCTGTAGAGTGACCGAACAAAATGCCTATAAATAGTCTGAGAATTTTCAATGTTGTAGGCCAGACTATTGTGTGAAAATTTAGAAAATAAATGACCATTTAAATCTTGTGCTGTGATGAACACCAATACAACAATCTGAATATTAGCAAGTTAGCTAAGCAAGACACAAGTAATGATCTGTTGTAACAATATGTTTCCTCAGGACTACTGGAAGTGTCCCAAATGTGACCAGTTCAACCCTCCTCTTCCTCGACACTGCAAAACCTGCTGGACCGTCCGAGCTGATTGGCTTCCAGAAACACACTCCAACTGGGAAAACCTTTCAAGAAATACT[C/T]GAACCAACCCCGAAGACACCAGCGTCACCACAACTCCCAACACAACCTTCGAAAAGAAACTCTCCAAACCCTCAAGCCCTCTCCCAGAAACAGATGATGGAGTGGACGTACCCGACGGCAAGTGCTTTCCATCTCCTGCCACTACCAAAGATGAGCTTCCCTCCTCTGCTACCATTACTGACTCTCAGACCACATCATCACAGCCCTCCACTTCCTCCGGCGGGGGCAGCAGTCAGGAAGAGACCCCCGAGCTGGAGCGCTTCAACAGTCTGGAGGCCTGCCTTCCCGCTACGTGCCTAGAACCCTGCGTCATCTGTCAGAGTCGCCCCAAGAACGGCTGCATTGTTCACGGAAGGACTGGGCACCTTATGGCGTGCTACACATGTGCCAAAAAATTAAAAAACCGGAACAAGTTGTGTCCGGTGTGCCGAGAGCCCATTCAGTCAGTGGTGTTGACTTACATGAGCTGAGGCACTGAAATATACCTCCTCCTGTCCTTA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa26298
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > C
Consequence:
Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000040435 Splice Site 356 445 10 14
ENSDART00000077854 None 356 475 11 11
ENSDART00000122675 None 356 475 10 10
ENSDART00000139543 None None 159 None 8

The following transcripts of ENSDARG00000033443 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 4 (position 22070153)
Other Location(s):
Assembly Chromosome Position
GRCz10 4 23413488
GRCz11 4 23134463
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CTCTCCAAACCCTCAAGCCCTCTCCCAGAAACAGATGATGGAGTGGACGT[A/C]CCCGACGGCAAGTGCTTTCCATCTCCTGCCACTACCAAAGATGAGCTTCC
Long Flanking Sequence:
AAAGACCTGTAACATGTAGTGTTAGTGGTCCTTCAGGAATGTGGTTGAGAAACACTGCTGTAGAGTGACCGAACAAAATGCCTATAAATAGTCTGAGAATTTTCAATGTTGTAGGCCAGACTATTGTGTGAAAATTTAGAAAATAAATGACCATTTAAATCTTGTGCTGTGATGAACACCAATACAACAATCTGAATATTAGCAAGTTAGCTAAGCAAGACACAAGTAATGATCTGTTGTAACAATATGTTTCCTCAGGACTACTGGAAGTGTCCCAAATGTGACCAGTTCAACCCTCCTCTTCCTCGACACTGCAAAACCTGCTGGACCGTCCGAGCTGATTGGCTTCCAGAAACACACTCCAACTGGGAAAACCTTTCAAGAAATACTCGAACCAACCCCGAAGACACCAGCGTCACCACAACTCCCAACACAACCTTCGAAAAGAAACTCTCCAAACCCTCAAGCCCTCTCCCAGAAACAGATGATGGAGTGGACGT[A/C]CCCGACGGCAAGTGCTTTCCATCTCCTGCCACTACCAAAGATGAGCTTCCCTCCTCTGCTACCATTACTGACTCTCAGACCACATCATCACAGCCCTCCACTTCCTCCGGCGGGGGCAGCAGTCAGGAAGAGACCCCCGAGCTGGAGCGCTTCAACAGTCTGGAGGCCTGCCTTCCCGCTACGTGCCTAGAACCCTGCGTCATCTGTCAGAGTCGCCCCAAGAACGGCTGCATTGTTCACGGAAGGACTGGGCACCTTATGGCGTGCTACACATGTGCCAAAAAATTAAAAAACCGGAACAAGTTGTGTCCGGTGTGCCGAGAGCCCATTCAGTCAGTGGTGTTGACTTACATGAGCTGAGGCACTGAAATATACCTCCTCCTGTCCTTAAATGAAGTTTGGGAGTTGCCTTGTGGTTGTATTAGATATAAACGTTTGTTTTCAAATTCAATATTTGTAATGATTCAATATTTTTTTCTTATTGAATACCTAATTTTATT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa16808
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
C > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000040435 Nonsense 416 445 14 14
ENSDART00000077854 Nonsense 446 475 11 11
ENSDART00000122675 Nonsense 446 475 10 10
ENSDART00000139543 None None 159 None 8

The following transcripts of ENSDARG00000033443 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 4 (position 22070423)
Other Location(s):
Assembly Chromosome Position
GRCz10 4 23413758
GRCz11 4 23134733
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
AAGAACGGCTGCATTGTTCACGGAAGGACTGGGCACCTTATGGCGTGCTA[C/A]ACATGTGCCAAAAAATTAAAAAACCGGAACAAGTTGTGTCCGGTGTGCCG
Long Flanking Sequence:
TGTCCCAAATGTGACCAGTTCAACCCTCCTCTTCCTCGACACTGCAAAACCTGCTGGACCGTCCGAGCTGATTGGCTTCCAGAAACACACTCCAACTGGGAAAACCTTTCAAGAAATACTCGAACCAACCCCGAAGACACCAGCGTCACCACAACTCCCAACACAACCTTCGAAAAGAAACTCTCCAAACCCTCAAGCCCTCTCCCAGAAACAGATGATGGAGTGGACGTACCCGACGGCAAGTGCTTTCCATCTCCTGCCACTACCAAAGATGAGCTTCCCTCCTCTGCTACCATTACTGACTCTCAGACCACATCATCACAGCCCTCCACTTCCTCCGGCGGGGGCAGCAGTCAGGAAGAGACCCCCGAGCTGGAGCGCTTCAACAGTCTGGAGGCCTGCCTTCCCGCTACGTGCCTAGAACCCTGCGTCATCTGTCAGAGTCGCCCCAAGAACGGCTGCATTGTTCACGGAAGGACTGGGCACCTTATGGCGTGCTA[C/A]ACATGTGCCAAAAAATTAAAAAACCGGAACAAGTTGTGTCCGGTGTGCCGAGAGCCCATTCAGTCAGTGGTGTTGACTTACATGAGCTGAGGCACTGAAATATACCTCCTCCTGTCCTTAAATGAAGTTTGGGAGTTGCCTTGTGGTTGTATTAGATATAAACGTTTGTTTTCAAATTCAATATTTGTAATGATTCAATATTTTTTTCTTATTGAATACCTAATTTTATTTATGACTCGTCGATTTCACTCACACGTTTTGTAATAAATTCACACACTTATATTTTAAGGATTGTGTTAGAATTGAAACAAAAGCTTGTGAGGTGCTGTATTGATTAAATAGTCTAATAGAAATGTTTGTAATTTAATTTATGTACATGCAGATGTAGAGGTTTTTGAGTTGTTTGCTGCACTGAAAAAGAGTTCCCCGAGCTCATTTAAAAATGTTCTTATGATATTTCGGCTGCGAAGACTGTCTTATTTTCTTTCAGAAAGACATAA
Associated Phenotype:
Not determined