Busch Lab

ZMP

notch3

Ensembl ID:
ENSDARG00000052139
ZFIN ID:
ZDB-GENE-000329-5
Description:
neurogenic locus notch homolog protein 3 [Source:RefSeq peptide;Acc:NP_571624]
Human Orthologue:
NOTCH3
Human Description:
notch 3 [Source:HGNC Symbol;Acc:7883]
Mouse Orthologue:
Notch3
Mouse Description:
Notch gene homolog 3 (Drosophila) Gene [Source:MGI Symbol;Acc:MGI:99460]

Alleles

There are 6 alleles of this gene:

Allele Name Consequence Status Availability
sa33321 Nonsense Mutation detected in F1 DNA Not yet available
sa14943 Essential Splice Site Available for shipment Available now
sa16743 Nonsense Available for shipment Available now
sa20147 Nonsense Available for shipment Available now
sa40169 Nonsense Mutation detected in F1 DNA Not yet available
sa33320 Nonsense Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa33321
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000073930 Nonsense 14 2468 1 33
Genomic Location (Zv9):
Chromosome 3 (position 54197153)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 53304468
GRCz11 3 53559131
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CACAAAAATATGGGGAATTACAGCCTTTGGATATTTTTGTCAATTTTATA[T/A]CTGGTGCACAACAGCGAAGGTAAGATGACTGATCCTTTTCTTCATTTTTG
Long Flanking Sequence:
TACAAAACGCAAAGGTTATTTGAGTTTAACTTTTACCAAACCCTCTTCTCCAAAGGGGAAAAAAATAATGCTTTCTCAAAGCAAACCCCTGACGAATCCGCACTATTCCGCCAAGCGGAGAGGCGAACAACACCCTTAAGTGAGCGCAGGCTTGAGCAGGGGGCGGAGGGATACGAAGCCAGCCGATGGACTCCGATCCGAAGTGAAGTAGAGAAACTTTTTCAAAAGTTCCTGGAGGTATTTCGAGACGCACGGCAGCCGAGTCCGAGCTGCAGAAGGAAATACTGAACTGGACTATATCGAAACGCTTAATTTCTATGAAATTCACTGAAAAGAACTGCATGACGCTACTTCATCCTAATGTGATTGCCTGGAGCTTCAATCGCCGATTCATTTCTTAAAGGATGTATTTTTGCTAACATTTTCAAAAAAGGAGTAGGATCGAGTTTCCACAAAAATATGGGGAATTACAGCCTTTGGATATTTTTGTCAATTTTATA[T/A]CTGGTGCACAACAGCGAAGGTAAGATGACTGATCCTTTTCTTCATTTTTGACTAGGTTTATCCGAGTCTGGGACATGTATGGACATACAACCTGTTCCATTAGAAGCATTGAAACATCATCACGTCCTGTCTGCGACCTAATCATTTATTTTACGGGGTCCAGAATTATCACATTTTGTTAGTTTATACGAAGCGTCAGTTTGTTGTAAGATGAATACATCTGAATACATCAGTTCTCATAAACGAGCTCGTTTCAAAAATCACAAAATAAATAAACATTTAAATGTAAAGTAAGCTGTCTTTTATTTGCGATAAACAGTGGCGCAAATTTACATAAGCATCGACTACTGTTGTGAGCATCGCCGCAGAACATTACGCACAAATATTCACTGATGATGGGATTTAAAGTCTTCAAAGCATCCACTGTTGCACATGGGGACACTTTCTCTTTGTTGCTGAGGCATGCATTCGCTAATTGTTTGTTGTGGGGATAAATTCTG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa14943
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000073930 Essential Splice Site 511 2468 10 33
Genomic Location (Zv9):
Chromosome 3 (position 54180245)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 53287560
GRCz11 3 53542223
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
NNNNNNNNNNNNNNNNNNNNNCACCGACCTAATGGATATGAATGCCGMTGTGCTGAAG[G/A]TAAGTTTATAAATCAATATATCAATGCAATTGTGTGTTTAAGGATCTATY
Long Flanking Sequence:
ACCCTCTAAAGATGCAGGAATGAACACTTCTGTGGGACACCAGACTTTTTTTGTACTTACTAGCATATTTTCACAGACAGGGTTTAAGGCCTCCTGCAAGCTCAGTGCCTACACAAGTGCACATTTTTTCAGATAATGTAATTTAATTGATGGCAGAAATGTATGAAAAGCTAATTAACATCCAAAAATGGACAGTTAACATTCATTTGCTATAACATACAGATTGAGATGTATAGATTTTAGCTTTAAATAAAGCAAGGTGCAGATATCTTCTACTTGGCTAAGCCCTACTGCCCCTAAAGCTGAACCTAATGACCCAACCAGTGTGAGGAGCTCACCTCCGCTGCCTTAGACTGACCCCTAACCTCTATGTTTGCCTGTCCCAGGGTTTACTGGCACCATGTGTCAAATCGACATTGATGAGTGCGCCAGCACTCCTTGCCAGAATGGAGCCAAGTGCATTGACCGACCTAATGGATATGAATGCCGCTGTGCTGAAG[G/A]TAAGTTTATAAATCAATATATCAATGCAATTGTGTGTTTAAGGATCTATTTAAGAATCGAAAGCATCAAAAATGAATTGCATGATCTCAGAATCAGAGTCTTTACATTTGTATTATCGTATTCTGAGGCAGACTGTCGAGAAATCCCAGATCCCCCTCTTCTGCTGCCAATGTCACAGGGTCACCAATGCTGGCAGCTGCTGATGAGGGGGTTATGCTCGGTCATCACCCCGACATCTGTTCATCTGTAACCTACAATGCATACCCACACAGCACCGTATGGCACAACTAAAACTCCCAGCATTTACCTTCACAAAGTTGTACCTGTATGAATAGCTGGTTTCTGTTTTTTTATTTATTTATTTAATTAGCCCCAATGTGTATGGTACAATTTTGGGGTACAATACAGTACACACTGCATGTGCTGCTAGGCTTTTAGAAAGCACAGACATGCAGTTTGTGTATTGTCTGAAGCAGCCTGCTGTTTGGTATTCTCCGTGC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa16743
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
C > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000073930 Nonsense 607 2468 12 33
Genomic Location (Zv9):
Chromosome 3 (position 54178688)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 53286003
GRCz11 3 53540666
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
ACCAACTGTGAAATCAACTTTGACGACTGTGCYAGCAACCCTTGTGACTA[C/A]GGAATTTGCAAAGATGGCATAAATCGCTATGAGTGTGTCWGCAAACCTGG
Long Flanking Sequence:
CAAATGCAATTTATAAATCTGTTAAATCTCTCTTCACACAACTATACTCAGCTCTTCAAATGTTGGGCTATCTTAGAATCACCTTTCTCTGCTTATTTGTTTTTACACATCTTTTCTTTGTCCTCAGGTTTTGAAGGAAGACTGTGTGAGAGCAACATTGATAATTGTAAGCCTGACCCATGCCACCATGGTACTTGCGTAGATGGCATTGCCAGTTATACTTGCAACTGTGAGCCTGGCTACACTGGCTATCGCTGCGAAAACCAGCTCAATGAGTGCCATAGCAACCCCTGCCAGAATGGTGGCAAATGTGTTGACCTTGTCAACAAATACATCTGCCAGTGTCAACATGGCACTTCAGGTGAGGAATTATGTATTACAGATTCATCTGCATTGGCTATATCATTTTTACACCATTTCTTAATAACACTGTTTGATTCCCACAAAGGTACCAACTGTGAAATCAACTTTGACGACTGTGCTAGCAACCCTTGTGACTA[C/A]GGAATTTGCAAAGATGGCATAAATCGCTATGAGTGTGTCTGCAAACCTGGCTTTACCGGTGAGATGGGTGGAACACCCACCTTAATCATTTTAAACAATCACAAGAGTTGGCAAATTCACAAATGCAAAAGAGAAATCACATTTTGACCGTCCCTTCTTTTCAGGACCTCAATGTAAGGATGAGATAGATGAGTGCCAGTCGAATCCCTGTCGCAATGGAGGGACCTGTGTAGATGATGAGAATGGCTTCCACTGTCAGTGCCCTGAAGGGTTCCATGATCCCTACTGCTATTCACAAGTGGATGAGTGTGCCAGCAATCCATGTTTACATGGGACCTGCAGGGATGACCCTAATGGGTACAGCTCCATAACACATTTTAAAAAGCAGGAGAAAGAAAAAAAAAGGAACTTGTTTTCACTGTTACTCTTGTTTAAACTGCTCCTACAGCTATCGGTGTGACTGTGAGCCTGGATGGGTGGGTAAGAACTGTGACCTAGAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa20147
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000073930 Nonsense 1377 2468 24 33
Genomic Location (Zv9):
Chromosome 3 (position 54172611)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 53279926
GRCz11 3 53534589
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CCAGCTATCCATTTTTTCACTGCCAGTGCACCAATGGCTGGAAAGGCAAA[C/T]GATGTGAACAGAAAACTGGGTCATCGGCTCCACTTCCTTCTCCTTGCCCT
Long Flanking Sequence:
TTTGTGTGTCTAAATAAAGTTCATTGTGTCTCCAGGACGAGGGTGTCAAAGTAGATTCAGCGTGTGCGAGTCTCAGCCCTGTAAAAATGGAGGAGTATGTTCCTTGTCTGGCAGCTCCCCACCAGGATACTCTTGCACTTGTCAGCTTGTGAGTATCCTGGCTTGAAATGAGATCATTTAACACTATGTTACTACCACTTTCCTCTAGACTTCAAAAGCAGTAACTTAAATCATTATCGTCTCTTTTTTAGGGGTACGCAGGTTCTAACTGTGAGAGGAGCATGAACTGCAAAGAGCTGCCTTGCTACAATGGAGGCAGTTGCACTCTCACCACACGAGGGGCACGTTGTACTTGCATTCAGGGCTTTGGTGGGCCATTGTGTCAGCACCGCAGCAATGACGGCTGCTCCTCCAAGCCATGCCACAATGGAGGCTTATGTACAGAGGAAACCAGCTATCCATTTTTTCACTGCCAGTGCACCAATGGCTGGAAAGGCAAA[C/T]GATGTGAACAGAAAACTGGGTCATCGGCTCCACTTCCTTCTCCTTGCCCTATTGCTGACTGCTTCAGCAAGGCCAATGACGGTGTGTGTGACAAAGAATGCAACTCCTTAGACTGCCGCTGGGACGGAGGTGACTGTTCTCTTGCTGTAAACCCCTGGGCACGCTGTGCAGACCCTCGATGCTGGCGGCTCTTCAATAACAGCCAATGTGACGAGTTTTGCAATAACGCAGAGTGCCTGTTCGATAATTTCGACTGCATAAACAAAGAGAAAGTCTGCAAGTAAGTTCTGTATTCATTTTTTGTCTTGCTTTATATAACAGTTTATGATGTTCCATTCCCAATACACTTTCTCTTCCCTCAGCCCCATCTATGAAGCATACTGCACTGACCATTATGCAGATGGACTCTGTGATCAAGGATGCAATACTGAAGAATGTGGCTGGGATGGACTGGATTGTGCAAGGAAGATTCCAGAAGACCTTGCTGAAGATATGCTTGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa40169
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000073930 Nonsense 1384 2468 24 33
Genomic Location (Zv9):
Chromosome 3 (position 54172589)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 53279904
GRCz11 3 53534567
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CCAGTGCACCAATGGCTGGAAAGGCAAACGATGTGAACAGAAAACTGGGT[C/A]ATCGGCTCCACTTCCTTCTCCTTGCCCTATTGCTGACTGCTTCAGCAAGG
Long Flanking Sequence:
ATTGTGTCTCCAGGACGAGGGTGTCAAAGTAGATTCAGCGTGTGCGAGTCTCAGCCCTGTAAAAATGGAGGAGTATGTTCCTTGTCTGGCAGCTCCCCACCAGGATACTCTTGCACTTGTCAGCTTGTGAGTATCCTGGCTTGAAATGAGATCATTTAACACTATGTTACTACCACTTTCCTCTAGACTTCAAAAGCAGTAACTTAAATCATTATCGTCTCTTTTTTAGGGGTACGCAGGTTCTAACTGTGAGAGGAGCATGAACTGCAAAGAGCTGCCTTGCTACAATGGAGGCAGTTGCACTCTCACCACACGAGGGGCACGTTGTACTTGCATTCAGGGCTTTGGTGGGCCATTGTGTCAGCACCGCAGCAATGACGGCTGCTCCTCCAAGCCATGCCACAATGGAGGCTTATGTACAGAGGAAACCAGCTATCCATTTTTTCACTGCCAGTGCACCAATGGCTGGAAAGGCAAACGATGTGAACAGAAAACTGGGT[C/A]ATCGGCTCCACTTCCTTCTCCTTGCCCTATTGCTGACTGCTTCAGCAAGGCCAATGACGGTGTGTGTGACAAAGAATGCAACTCCTTAGACTGCCGCTGGGACGGAGGTGACTGTTCTCTTGCTGTAAACCCCTGGGCACGCTGTGCAGACCCTCGATGCTGGCGGCTCTTCAATAACAGCCAATGTGACGAGTTTTGCAATAACGCAGAGTGCCTGTTCGATAATTTCGACTGCATAAACAAAGAGAAAGTCTGCAAGTAAGTTCTGTATTCATTTTTTGTCTTGCTTTATATAACAGTTTATGATGTTCCATTCCCAATACACTTTCTCTTCCCTCAGCCCCATCTATGAAGCATACTGCACTGACCATTATGCAGATGGACTCTGTGATCAAGGATGCAATACTGAAGAATGTGGCTGGGATGGACTGGATTGTGCAAGGAAGATTCCAGAAGACCTTGCTGAAGATATGCTTGTTATTGTAGTCCTACTGCCCCCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa33320
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000073930 Nonsense 1497 2468 25 33
Genomic Location (Zv9):
Chromosome 3 (position 54172167)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 53279482
GRCz11 3 53534145
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TATGCAGATGGACTCTGTGATCAAGGATGCAATACTGAAGAATGTGGCTG[G/A]GATGGACTGGATTGTGCAAGGAAGATTCCAGAAGACCTTGCTGAAGATAT
Long Flanking Sequence:
AGGAAACCAGCTATCCATTTTTTCACTGCCAGTGCACCAATGGCTGGAAAGGCAAACGATGTGAACAGAAAACTGGGTCATCGGCTCCACTTCCTTCTCCTTGCCCTATTGCTGACTGCTTCAGCAAGGCCAATGACGGTGTGTGTGACAAAGAATGCAACTCCTTAGACTGCCGCTGGGACGGAGGTGACTGTTCTCTTGCTGTAAACCCCTGGGCACGCTGTGCAGACCCTCGATGCTGGCGGCTCTTCAATAACAGCCAATGTGACGAGTTTTGCAATAACGCAGAGTGCCTGTTCGATAATTTCGACTGCATAAACAAAGAGAAAGTCTGCAAGTAAGTTCTGTATTCATTTTTTGTCTTGCTTTATATAACAGTTTATGATGTTCCATTCCCAATACACTTTCTCTTCCCTCAGCCCCATCTATGAAGCATACTGCACTGACCATTATGCAGATGGACTCTGTGATCAAGGATGCAATACTGAAGAATGTGGCTG[G/A]GATGGACTGGATTGTGCAAGGAAGATTCCAGAAGACCTTGCTGAAGATATGCTTGTTATTGTAGTCCTACTGCCCCCAGAGGAGCTTCTAAGGACACAAACAGCTTTCCTGCAGAAACTAAGTGCCATCCTACGCACCACGTTGCGCTTCCGTCTCGATCGAAATGGAGATTACATGATCCGACCTTACACAGGCCGTGAGACGCGCATTAAACGGGAGCTTAATCCTCAGGAGGTCATTGGGTGAGTTGCAGAAAAAAAAACTACTTCACATACATTTTCATATTGTCAAAATAACACAGGTTAAATGTAATAATCTCAGCAGGAACCTGAATGATCAAGAATTGCGTTCTCTGCACAGATTTGGGAGTTTTACACTTTTACTCTTTGGCTTCTCTGCAGGTCCATTGTATATTTGGAAATAGACAACAGGCTGTGCTCTCAGGGCTCAGATGACTGCTTCCGCAATGCTGACAGTGCTGCTGAATACCTTGGTGCTCT
Associated Phenotype:
Not determined