Busch Lab

ZMP

tgfb1a

Ensembl ID:
ENSDARG00000041502
ZFIN ID:
ZDB-GENE-030618-1
Description:
transforming growth factor, beta 1a [Source:RefSeq peptide;Acc:NP_878293]
Human Orthologue:
TGFB1
Human Description:
transforming growth factor, beta 1 [Source:HGNC Symbol;Acc:11766]
Mouse Orthologue:
Tgfb1
Mouse Description:
transforming growth factor, beta 1 Gene [Source:MGI Symbol;Acc:MGI:98725]

Alleles

There are 4 alleles of this gene:

Allele Name Consequence Status Availability
sa16296 Essential Splice Site Available for shipment Available now
sa39024 Nonsense Mutation detected in F1 DNA Not yet available
sa42471 Nonsense Mutation detected in F1 DNA Not yet available
sa39023 Nonsense Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa16296
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
G > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000060839 Essential Splice Site 108 377 1 7
Genomic Location (Zv9):
Chromosome 15 (position 2794641)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 2839705
GRCz11 15 2802988
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GGATGAGGACTAYTTTGGCAAGGAGGTGCATAAGTTCGTYTTCCAGCAAG[G/T]TTAGACATTTAAAGTACTTTTTTTTNNACTTCTTATTGTAGTATTCGATR
Long Flanking Sequence:
GGTCTTAGGAAATTCCCATATTGACGGACATCATCTGTTCTGCTGAGTCCATTATTCAAGGTGTTTTCCAGACTCCTCAACAGGTAGCATCACCTCTATAATCAGACGCTTTTCGATCCTTTCCATTTCATTTTTTCCTTGCTCGCTGGACAGTTTGGTCGTACATTTCAGCATTATGAGGTTGGTTTGCTTGGTGCTGACCGCCCTGTGTTTGGTCACGGGAACGGGCAGCATGTCCACCTGTAAGACTCTGGATTTGGAGGTGGTGAGGAAGAAGCGGATTGAGGCTATTCGGGGTCAGATCCTCAGTAAACTGCGCATGGCTAAAGAGCCTGAATCCGGAGCGGACGACGACGGACAGAAGATCCCGGATTCCTTGCTTTCGTTATATAATAGCACTGTTGAACTGAGCGAAGAAATGAAGACGAAGATCGTCCCTGTGCAGGATGAGGATGAGGACTATTTTGGCAAGGAGGTGCATAAGTTCGTCTTCCAGCAAG[G/T]TTAGACATTTAAAGTACTTTTTTTTTTACTTCTTATTGTAGTATTCGATGTTTATGTTTATGTCAGCATTCTGTCATCAGATATTATGAACAATAATCATTGTGTAACTGTGTTTGAGTTGCTTTATGATGATAGGAATGTAAAATGGTTGCACAATTCATTTAAAGTCTATCCTAGACAATCAATTCACTACTTGTGTAATTTATTCGAATCTTATTGTACTCGTGTTGATATACCCCACGATGTGATGTTGATGATCACTAGATATTTTTCAACATACTAATATTCAGCTTAAAGTAAGTAGGTAACTACTTAACTAGGTTAACTAGGCAGGTTAGGGTAATTAGGCAAGTGTTTGTATAACGATGGTTTGTTCTGTAGATTATCGAAAAAAAAAGAGGCTAATAATTTTGTCCCTAAAATGGGTTTTTAAAAATGTAAAACTGCTTTTATTCTAGCCGAAATAAAACAAATAAGACTTTCTCCAGAAGAAAAAATAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa39024
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000060839 Nonsense 275 377 4 7
Genomic Location (Zv9):
Chromosome 15 (position 2778752)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 2823816
GRCz11 15 2787099
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TTGCATCCGTTCGCAAGAAACGAGCTGTTGGCACCGATGAAACATGTGAT[G/T]AGTAAGTCTTTTTGCTGTCCTATGCTTTATATACAGCTGAAGTCACAAAT
Long Flanking Sequence:
TATTTACACAATAAGTACATTGTAACGAATTGTTAATTTCAAGTACATATTAGTTAAGGACCCTTATTATAAAGTGGGACCTAGTATTTTAAAGTGCAAAACAAGGTTTATTAAATGCTGTATGTATATTGTGTTTGTGTTTAACAGAAGATGAAGAAACCTTGGAGCTGAGGTTATACTGCGACTGTAAAGCAAACCAGCAGAGCACGGATAAGTTCCTCTTCACTATATCAGGTATGATAATCTCAGTAATCTGAAACAGTGCTGGATGTTTATGATGAAATAAGCTGATATGCTTATTTTTTTATCTTGTTTGTTTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTGTTCAGGGCTAGACAAGCAGAGAGGTGACACCGCTGGTCTGGCAGATATGATGGTGAAGCCGTACATTTTGGCTTTATCTTTGCCTTCAAATGGCAACTCTCTTGCATCCGTTCGCAAGAAACGAGCTGTTGGCACCGATGAAACATGTGAT[G/T]AGTAAGTCTTTTTGCTGTCCTATGCTTTATATACAGCTGAAGTCACAAATGTGGCACAGTGGGTAGCACAATCACCGTACAGCAAGAAGGTCGCTGGTTTGAGCCCCGGCCGGGTCAGTTTCTATGTGGAGTTTGCATGTTCTTGTGGCTGGAAGGGCATCCTCTGCGTAAAAAACTTGCTGGAAAAGTTGTCGGTTCATTGCGCTGTGGTGACCCCGGATTAATAAAGAGACTAAGCTGACAAGAAAATCAATGAATGAATGAATGAATGTTGTTTTGTCATGTTCACCTTTTTGCTGGATTTTTGTCTTCACTTTGTGTAAAATAAATCACGCTTCACCTTCAACAGCGGCTTCTGTGACACTTTTTGCCTCCATCCGCCCGGTCAATCGTAACACTACCTTTCAGAATGGCTTAACACTAGTGCACTAGACTATGTGTGCCTTGGCTACTTTGCCGACCAGTTCAGCTAGATTATGTGTGCCTGGGCTACCTTGCTG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa42471
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000060839 Nonsense 300 377 5 7
Genomic Location (Zv9):
Chromosome 15 (position 2776073)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 2821137
GRCz11 15 2784420
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GCAAGCTTTACATTGACTTTCGGAAAGATCTGGGTTGGAAGTGGATCCAC[A/T]AGCCCAAGGGGTACTTTGCCAACTACTGCATGGGGTCCTGCACCTACATC
Long Flanking Sequence:
CGTGTCTCCCTCCCGGTCCTCAAATAGGCTACATCACGCACCCTTTTCACCCCTCCCCACCGCATCTCTCCTCACTCTTCAGACACATCGCGCCTCCACCAAACCACCACCTCTCCTGACAGCTGAGCGGGACTCAATAAACCCTGACACTCTGACCAATGTGAGGAGAGTTTACTCGCACGTGACTTGTTTTAGCTCTTTTGGTCCGATTAGAAACTTTGCAGTGTGAAAGCGAACCGCTCCAAGAGCAAAGAGCAACAATGTAACAATTGTAATCTCTGTTTCGGAACAACTGAATCGATTCACAGGTGTGAAAGCAGCCTTATTCATTAACTGCTATAGTTACAAAAGTTGAATACTGCAGCTTTAAGCAAGAACCACTGAATACAGATAATCAAAATCTCTCCTTCCCAATATTCTCTGGCAGAAAAACGGAGACCTGCTGTATGCGCAAGCTTTACATTGACTTTCGGAAAGATCTGGGTTGGAAGTGGATCCAC[A/T]AGCCCAAGGGGTACTTTGCCAACTACTGCATGGGGTCCTGCACCTACATCTGGAATGCTGAGAACAAATACTCACAGGTAGCCTGTTTTGTTTTGTTATTACTGTCCCATTTAACTAACGTGACAAATTATTAAAGATATAAACAAACTAGTCATTAAATCTATTCAATAGTTATTTTATTAGTTCCTAAACTCAAGGTTGCTGTACAAATATAATGTTATAAAAATGTGACAAATTACAGTCATGCACTTTGGATTTTGTTGCCATGTTTTTTTTTTTTGGGGGGGGGTGGGGGGGATTTTGTTGCCTCTAGGGATGGTGCACAACATCCCTGCTGAAAAATCCAGCTTATTCTTAAACCAGCTGGTTTAAGCTGGTTGACCAGGCTGGTTTTAGAGGGGTTTTGGGCATTTCCAGGCTCAATTCCAGCCTGGTTTTAGCTGGTCTGGCTGGAAAATTACCAGCTAAATCCAGCTAAATCCAGCAACCAGCTTGACCAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa39023
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000060839 Nonsense 320 377 5 7
Genomic Location (Zv9):
Chromosome 15 (position 2776013)
Other Location(s):
Assembly Chromosome Position
GRCz10 15 2821077
GRCz11 15 2784360
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GGTACTTTGCCAACTACTGCATGGGGTCCTGCACCTACATCTGGAATGCT[G/T]AGAACAAATACTCACAGGTAGCCTGTTTTGTTTTGTTATTACTGTCCCAT
Long Flanking Sequence:
CGCATCTCTCCTCACTCTTCAGACACATCGCGCCTCCACCAAACCACCACCTCTCCTGACAGCTGAGCGGGACTCAATAAACCCTGACACTCTGACCAATGTGAGGAGAGTTTACTCGCACGTGACTTGTTTTAGCTCTTTTGGTCCGATTAGAAACTTTGCAGTGTGAAAGCGAACCGCTCCAAGAGCAAAGAGCAACAATGTAACAATTGTAATCTCTGTTTCGGAACAACTGAATCGATTCACAGGTGTGAAAGCAGCCTTATTCATTAACTGCTATAGTTACAAAAGTTGAATACTGCAGCTTTAAGCAAGAACCACTGAATACAGATAATCAAAATCTCTCCTTCCCAATATTCTCTGGCAGAAAAACGGAGACCTGCTGTATGCGCAAGCTTTACATTGACTTTCGGAAAGATCTGGGTTGGAAGTGGATCCACAAGCCCAAGGGGTACTTTGCCAACTACTGCATGGGGTCCTGCACCTACATCTGGAATGCT[G/T]AGAACAAATACTCACAGGTAGCCTGTTTTGTTTTGTTATTACTGTCCCATTTAACTAACGTGACAAATTATTAAAGATATAAACAAACTAGTCATTAAATCTATTCAATAGTTATTTTATTAGTTCCTAAACTCAAGGTTGCTGTACAAATATAATGTTATAAAAATGTGACAAATTACAGTCATGCACTTTGGATTTTGTTGCCATGTTTTTTTTTTTTGGGGGGGGGTGGGGGGGATTTTGTTGCCTCTAGGGATGGTGCACAACATCCCTGCTGAAAAATCCAGCTTATTCTTAAACCAGCTGGTTTAAGCTGGTTGACCAGGCTGGTTTTAGAGGGGTTTTGGGCATTTCCAGGCTCAATTCCAGCCTGGTTTTAGCTGGTCTGGCTGGAAAATTACCAGCTAAATCCAGCTAAATCCAGCAACCAGCTTGACCAAAGCTGGACATACAGTAGCTGGTTTTGGCTGGGCTCCCATCCTGGCTAAGCTGGTCAAGCT
Associated Phenotype:
Not determined