Busch Lab

ZMP

tnfa

Ensembl ID:
ENSDARG00000009511
ZFIN ID:
ZDB-GENE-050317-1
Description:
tumor necrosis factor, alpha [Source:RefSeq peptide;Acc:NP_998024]
Human Orthologues:
LTA, TNF
Human Descriptions:
lymphotoxin alpha (TNF superfamily, member 1) [Source:HGNC Symbol;Acc:6709]
tumor necrosis factor [Source:HGNC Symbol;Acc:11892]
Mouse Orthologues:
Lta, Tnf
Mouse Descriptions:
lymphotoxin A Gene [Source:MGI Symbol;Acc:MGI:104797]
tumor necrosis factor Gene [Source:MGI Symbol;Acc:MGI:104798]

Alleles

There are 3 alleles of this gene:

Allele Name Consequence Status Availability
sa16250 Essential Splice Site Available for shipment Available now
sa3045 Essential Splice Site F2 line generated Not yet available
sa43296 Nonsense Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa16250
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
G > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025847 Essential Splice Site 68 234 2 4
Genomic Location (Zv9):
Chromosome 19 (position 27505511)
Other Location(s):
Assembly Chromosome Position
GRCz10 19 27435623
GRCz11 19 27019846
KASP Assay ID:
2261-3380.1 (used for ordering genotyping assays)
KASP Sequence:
AWGKCTCTGTTTCTCTCTCTAGACCCAGGGCAATCAACAAGATGGAAGTG[G/T]WGAGTTTCAAATCTTCTTTGTCAGAGTTAAATCAGGTTATTTTGTTTTTT
Long Flanking Sequence:
GTGGGTGTGTGTGTTATATGACATCACTGGAGTTTCCCCTTCCTCTTCAGATCTTTAAAAAGAAAGAAGAAGCAGTTATTCTGAACATTACACTGATAGAACAACCCAGCAAACTCGATTTGACTTAACAAGACCTTATCAAAAGCATTTACACTTGTAGAATCTTTAAGACATACAGCAATTATGAAGCTTGAGAGTCGGGCGTTTTTGGATGTTGAAGAAGGAGAGTTGCCTTTACCGCTGGTGATAGTGTCCAGGAGGAAAGCTGGATCTTCAAAGTCGGGTGTATGGAGGGTGTTTGGGATCATTTTGGCTGTGGGCCTTTGTGCCGCTGCTGCCGTCTGCTTCACGCTCCATAAGGTGAAAATCCTGCCCCGTACATATTACAAAAATCTGTTATTGGTGTTTTAAACATGCAATTGCAGCTACATATTATCAGTTGCATAATCAATGTCTCTGTTTCTCTCTCTAGACCCAGGGCAATCAACAAGATGGAAGTG[G/T]TGAGTTTCAAATCTTCTTTGTCAGAGTTAAATCAGGTTATTTTGTTTTTTGTGAAACTCAGTCATCACACATGAATCATTTTTTCATGTCTTTGTCTTATCAGTGCTGAGACTCACATTGAGAGATCGCATTTCACAAGGCAATTTCACTTCCAAGGCTGCCATCCATTTAACAGGTGAGTGAGATTTTGAACCGCCACAGTAAACCAGCAGAAAATGACTGAAAAGCAACTTAATTATTTAATGTTCAATCCACTAAAATTTGTAAAACAGATTAAGTTAACTTAATTGATTTGTGTTGGGACAACATTGTGTGGAACCCAACATTTTTTTACAATGTGGGCAAAATATGGACAAACCGGACCATTAAAAAAAGTGGGTTTGGGTTTGTCGATATCTGAGCCAAATTTGGGTTGAATCAATTCTGCATTTTTTTGTGTGTAAAAGGATTGCAATTCTTCACTCCTAATGTCACAAATGTTTTAGTTAATGTTTTACTCC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa3045
Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025847 Essential Splice Site 69 234 2 4
Genomic Location (Zv9):
Chromosome 19 (position 27505512)
Other Location(s):
Assembly Chromosome Position
GRCz10 19 27435624
GRCz11 19 27019847
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
TGKCTCTGTTTCTCTCTCTAGACCCAGGGCAATCAACAAGATGGAAGTGG[T/A]GAGTTTCAAATCTTCTTTGTCAGAGTTAAATCAGGTTATTTTGTTTTTTG
Long Flanking Sequence:
TGGGTGTGTGTGTTATATGACATCACTGGAGTTTCCCCTTCCTCTTCAGATCTTTAAAAAGAAAGAAGAAGCAGTTATTCTGAACATTACACTGATAGAACAACCCAGCAAACTCGATTTGACTTAACAAGACCTTATCAAAAGCATTTACACTTGTAGAATCTTTAAGACATACAGCAATTATGAAGCTTGAGAGTCGGGCGTTTTTGGATGTTGAAGAAGGAGAGTTGCCTTTACCGCTGGTGATAGTGTCCAGGAGGAAAGCTGGATCTTCAAAGTCGGGTGTATGGAGGGTGTTTGGGATCATTTTGGCTGTGGGCCTTTGTGCCGCTGCTGCCGTCTGCTTCACGCTCCATAAGGTGAAAATCCTGCCCCGTACATATTACAAAAATCTGTTATTGGTGTTTTAAACATGCAATTGCAGCTACATATTATCAGTTGCATAATCAATGTCTCTGTTTCTCTCTCTAGACCCAGGGCAATCAACAAGATGGAAGTGG[T/A]GAGTTTCAAATCTTCTTTGTCAGAGTTAAATCAGGTTATTTTGTTTTTTGTGAAACTCAGTCATCACACATGAATCATTTTTTCATGTCTTTGTCTTATCAGTGCTGAGACTCACATTGAGAGATCGCATTTCACAAGGCAATTTCACTTCCAAGGCTGCCATCCATTTAACAGGTGAGTGAGATTTTGAACCGCCACAGTAAACCAGCAGAAAATGACTGAAAAGCAACTTAATTATTTAATGTTCAATCCACTAAAATTTGTAAAACAGATTAAGTTAACTTAATTGATTTGTGTTGGGACAACATTGTGTGGAACCCAACATTTTTTTACAATGTGGGCAAAATATGGACAAACCGGACCATTAAAAAAAGTGGGTTTGGGTTTGTCGATATCTGAGCCAAATTTGGGTTGAATCAATTCTGCATTTTTTTGTGTGTAAAAGGATTGCAATTCTTCACTCCTAATGTCACAAATGTTTTAGTTAATGTTTTACTCCT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa43296
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025847 Nonsense 140 234 4 4
Genomic Location (Zv9):
Chromosome 19 (position 27509152)
Other Location(s):
Assembly Chromosome Position
GRCz10 19 27439264
GRCz11 19 27023487
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GATTATCATTCCCGATGATGGCATTTATTTTGTCTACAGCCAGGTGTCTT[T/A]GCACATCAGCTGCACGTCTGAACTGACTGAGGAACAAGTGCTTATGAGCC
Long Flanking Sequence:
CCTCATTCACTTCCATTCATTTTTAGACATTATTAACAACTTGTTATGCTGTTTGATGTTGCACACTGACAGTTTCTTATATTATTCTAATTTGTCTTTATTGTCATGCAAACACTTGTTTGTAATGCAAGTAGTTTGACAATTTTCTGCGGTTTATTATTCCTAGTAATTTCTCCCACATGCAGCTAAATCGAATGTTCTAACATAATTGCAAAAATGAGCGCACTTCCTCATTGAAGAAATAAGGCCAATCTGAAAAATAATTGTAGAATTTAAGTAAATTACCAAGTAAAATCTGCATTCTGAGGCAAAACCTGTTGAGAATCACTGACTTAGACCATGTTTTTTGTTTATCCTAGGTGGATACAACTCTGAATCAAAGACCTTAGACTGGAGAGATGACCAGGACCAGGCCTTTTCTTCAGGTGGCTTGAAATTAGTAAACAGGGAGATTATCATTCCCGATGATGGCATTTATTTTGTCTACAGCCAGGTGTCTT[T/A]GCACATCAGCTGCACGTCTGAACTGACTGAGGAACAAGTGCTTATGAGCCATGCAGTGATGCGCTTTTCTGAATCCTACGGAGGCAAAAAGCCACTTTTCAGTGCAATCCGCTCAATCTGCACGCAGGAGCCTGAATCTGAAAATCTGTGGTACAACACTATTTACCTCGGCGCTGCCTTCCATTTACGAGAAGGAGACAGACTGGGCACAGACACGACCACAGCACTTCTACCGATGGTTGAAAATGATAACGGAAAGACCTTCTTTGGGGTGTTTGGTTTGTGAACGAAAGTGAGGAAAATGTTTTATTTTAAAACAGAAAGAACCAATGACCTCTATCATACACTCTTGGCAATGTGCCGCCAACACATCTGTACATTGCTGACTGTTGTTCAGAGACTATTATGCTATTATGTGCAACTGGCTTTAAACTTGCTTTATTTTATTGTTATTTGTGTTGGTATTTATAACTATTTATTAATTATTTATTTGTTGAATA
Associated Phenotype:
Not determined