Busch Lab

ZMP

crb1

Ensembl ID:
ENSDARG00000062245
ZFIN IDs:
ZDB-GENE-050208-382, ZDB-GENE-050208-543, ZDB-GENE-050208-543
Description:
crumbs homolog 1 [Source:RefSeq peptide;Acc:NP_001038408]
Human Orthologue:
CRB1
Human Description:
crumbs homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:2343]
Mouse Orthologue:
Crb1
Mouse Description:
crumbs homolog 1 (Drosophila) Gene [Source:MGI Symbol;Acc:MGI:2136343]

Alleles

There are 7 alleles of this gene:

Allele Name Consequence Status Availability
sa14330 Nonsense Available for shipment Available now
sa29788 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa1482 Nonsense Available for shipment Available now
sa12558 Nonsense Available for shipment Available now
sa159 Essential Splice Site Confirmed mutation in F2 line Not yet available
sa24173 Nonsense Available for shipment Available now
sa24174 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa14330
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
C > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000089774 Nonsense 155 1428 2 13
ENSDART00000141006 Nonsense 155 1428 2 13
Genomic Location (Zv9):
Chromosome 22 (position 24368195)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 23504549
GRCz11 22 23531113
KASP Assay ID:
2261-6861.1 (used for ordering genotyping assays)
KASP Sequence:
ARYCCAGGGTACGCATGCATCTGTCAGGAGGGTTACACTGGRAGATCTTG[C/A]GARAAAGAGGTGGACCACTGCTCTCCTAACCCCTGCMGAAACCGCGCCAT
Long Flanking Sequence:
AAGAATGTTCATTTTTGGGTGAACTTTCCCTTTAAGAGTATAACTATGCTGCATGCTCTTCCTTTTTATGGGAGCAGAATGTTAAACAAATGTCTAAATGTCCATGTTTTTATCCTTGTAGGTGTAACACTACTCAAGACCTCAACACTCTGCCTGGACAACCCTTGCCAACACCAGTCAGAGTGCAGGGAAGCCCTGTCTGATTTCCTGTGCCAGTGTCAGACGACTGTGCCAGTCTTTCCCAGCACGCGTTGTGATTCTTCCAGTACGTTCTGCCAACTGTCCATCTGCCAGGGCAATGTGACATGTCAACCCACCGGCGCCCACCCAGGGGAACTAGTTTGCCAGTGTGACTCCGGCTTGCTGGGGCAGGACTGTCTTTCCAGTGCCCAGCTCTGCGCTCAGGGGCATTGTGGGGACAGTGCCCACTGTCTGGCAGTGCGAGACCAGAGCCCAGGGTACGCATGCATCTGTCAGGAGGGTTACACTGGAAGATCTTG[C/A]GAAAAAGAGGTGGACCACTGCTCTCCTAACCCCTGCAGAAACCGCGCCATCTGCCGCAGCAGAAGGAATGGGCCCACTTGCTTCTGCGTGCCAGGATTCCAGGGCCAGCTCTGCGAGATTGAGGTGAATGAATGTGTGTCGAGGCCCTGTAGAAACGGAGCCACCTGTGTGGACAAGATCGGGCACTACATCTGTCTCTGCAGGCCTGGATACATGGGTAGGTGAAGTGAGGGAGAGAGAGAAAAGGGGGGTCTCATGCTTTGCTGCCAAGTGCCACTCACCTGTTTGACCAGACGTGTCAAACTGCACTGCTGAGTTTGGGCCACAGTCCAACAGAGTTTAGTTCCAACCCTTCTCCAACATGTACACATTTTCAAATAAGTCTGAAGGTCTTTATTAGGTGGATCGGGTGCTTCAACTTTTTTGGAAATAGATTCGTTAGTTGCCTCTGATTATTGCCAAATTTTAATCCATTCAGTGATTTAAAATATTTGTTTATG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa29788
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > T
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000089774 Essential Splice Site 340 1428 4 13
ENSDART00000141006 Essential Splice Site 340 1428 4 13
Genomic Location (Zv9):
Chromosome 22 (position 24375394)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 23497350
GRCz11 22 23523914
KASP Assay ID:
2261-6862.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CGCCCTCTGTGAGAATCAACAGGAGAACTACACCTGCAACTGCTGGCCAG[G/T]TGACTCGCAGAATGACTTGTATATCAAGTTAAAGTATGATTTTGCATTAA
Long Flanking Sequence:
CTCTGATAACTAATTTCTTTAGTCTTTACCATAATAATAGTACATAATATATTTCTAATAATTTTGCAAGGTACTAGTTTTCAGCTTAGTGCCGTTTTAAGGCCTTAACTAGGTTAACTACAAGTTAGATCAGTTAGTCACTGTTCAGTAGCCAACCAGTGCTTAACACACTGCTTAAATAAACTGCAGTAACCATCTTAATGATTCTAAAATAGGTTAATTCATATAGTGTTTTTCATTGCTGGAATGTGTTCTCATTAGCTTCACCTATTGTAATATAATAACACAGCAAATGTAAGATAATTTTGGTAGTGAAATATGCATGCATGTATAAATAGTATAGCCTATATGTTGTAGCTACCGCTGTGACTGCTCACAGACTGCTAACTTCACTGGTGTTGACTGTGAGATCCCGCCTCCGCCCTGCTGGTCTCAACCCTGCCTCAACAGCGCCCTCTGTGAGAATCAACAGGAGAACTACACCTGCAACTGCTGGCCAG[G/T]TGACTCGCAGAATGACTTGTATATCAAGTTAAAGTATGATTTTGCATTAAACGGAATTGATGGATTGGATTTGGAAATGTATCTGGTAACATCTGATTAAAAATGTTTATGTAGGCTAATATCCTCCTGAGACCCATTTTTTTCTGTGATTCCCTACATCCTTTGGCTTAAAAAAAGTTTTATTTAGAGTTTTTACATTTTGTTTTTATTTTTAATTTTACAGCATGCCCACTGTAGTGGACCACGGGACCATTTTAGTTTGAAACGACCGCCAAACTCAGACAACAAAGCTGTCCAGGATGTGGCTGTAAAGGGATATTAATCCAATATTAATGTAACAAAAATTAAACAAAAGCCATTTTTTCCTTTTATTTTTAATTTCCTGAAACAGCTTAGTCTGAGAGAGCCAAAAAAAAAGAAGAAGTGATGTTAATTCAAAATAAATTTAAAATAAAAGTGATTTAAAACTGATTGTCATTCACTAATTGTCTCTAATTCTC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa1482
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
G > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000089774 Nonsense 355 1428 5 13
ENSDART00000141006 Nonsense 355 1428 5 13
Genomic Location (Zv9):
Chromosome 22 (position 24377070)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 23495674
GRCz11 22 23522238
KASP Assay ID:
554-1407.1 (used for ordering genotyping assays)
KASP Sequence:
TTGTTCCAGGGTTTGAAGGGCGTAACTGTGAGGTAGACGTCAGTGAATGT[G/T]AAAGCAATCCCTGTGTGAATGAAGGCATTTGCATGGAGCTTTCTTGGAAA
Long Flanking Sequence:
ATTTTTGAACAACTTAATTGTTTTATGTTCAATCCACTTACATTTATAAAAATAATTAAGGTAACTTAATCGATTTTATTGGTACAACATGAAAGAATTAAATTAACTTATTAGTTTTTACAAATTTTAGTCAATTACACATAAAACAATTAAGTTGTCCCCAAAAAAACTTAAGAACTGTGTTGTTTCAGCTCATTTAAAATGAGTAGTTTGAACAAACATCCTTTTTAGTGTGTAGAAGGAATACTGCTCTGGCTCAAAGTTAACAAGAATTATTTATATTATACATTAAATGATTCATTACATTGTGTTTTATTAACATCTATACCCCTAGCCTAAACCTATCTTCACATTAATGTAAAAACAGTAATCATTGTTGTAGTGTCACAAAAATTGTGTATATTGATGTGCGTATACCACAGCATCATGAGGCTTTCTGTCATATTTGTGTTGTTCCAGGGTTTGAAGGGCGTAACTGTGAGGTAGACGTCAGTGAATGT[G/T]AAAGCAATCCCTGTGTGAATGAAGGCATTTGCATGGAGCTTTCTTGGAAAACACTTTACGGTACTGAGCCCCTGTTTACAGCTAGATACAATCCCAGACTTGCTTCCGGGTTCATCTGCAAGTGTCCGCCAGGATTCTCAGGTACCTGCAGACTTACAAACTCATTTATTTACACATACATTAACAAAAGCATTCTAAATAAAGCAGGATGGGTATCATTGTAAAACTTTGTGGACAAACTCTAGTGGAAACATTTATGTTCACTCTATATTGCAATTTCATTTAATAAAAGACCAAGCTCCTTCTGCAGAAAACATCACTCAAATCTTGTCTCTTCACGTCCATGTTTTAATTCTTTACCTAGTTTGGGTTAAGTTTTTTCTTTGTTTGAGGACAAAAATTATGTTTTCCTGTCGGACCCAATTAAATTAAACTTTCTGTTTTTTGTCCGCGCAACATGCTCCTTTCAAGACTTTCTGCTGATGAAAGGTGGTCACTGT
Associated Phenotype:
Normal
Stage Entity Quality Tag
Larval:Day 5
ZFS:0000037		 whole organism
ZFA:0001094		 quality
PATO:0000001		 normal
PATO:0000461

Mutation Details

Allele Name:
sa12558
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000089774 Nonsense 509 1428 6 13
ENSDART00000141006 Nonsense 509 1428 6 13
Genomic Location (Zv9):
Chromosome 22 (position 24380974)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 23491770
GRCz11 22 23518334
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
AAACGCTCACTGTGTTCTCCTTTGAGACAAGCAGAGCATTCTTGCACCTG[C/T]AGACCCCRCTGCTGGGTGCAGAAACWTAYTTCAATATCACGCTAAGCTTT
Long Flanking Sequence:
TTTGTTACAAACTCTTCTCTGACATTGGCACAGATGCAACAAATAGTTGTAAGGATAAACTCTTGCAGAACCTGGCTTACAATTTCAGTAAGAACAGTTTATCCTAAGGCAACAATCCTTGCTAAGTGCGTATTTGTCAGGACCTTTGACTGAACTCTACTCTTGTTTTTCCTCTTCCAGGTGCCTTGTGCGAGCAAAACACAACTGCCTGTACCACCAGCCCATGTCATAATGGAGCCACATGTGAAGACTTCCTAGGCAGCTACAAGTGCATCTGCCCTTCTGAAAGCCAAGATGGAGTCCTCTACGGTGGTCGAAACTGTAGCGAGCCTCTTACAGGTTGCGAAGGTCACGAGTGCCAGAACGGAGCGTCCTGCATCCCATTCCTCAGCGAAGGTGTACATGGATACAGTTGCATCTGTCAGCCTGGCTACACCGGCTCTTACTGCCAAACGCTCACTGTGTTCTCCTTTGAGACAAGCAGAGCATTCTTGCACCTG[C/T]AGACCCCGCTGCTGGGTGCAGAAACATATTTCAATATCACGCTAAGCTTTCGTACAGTCCTGGAGAACACAGTGCTCTTCCAAAGGGGCAGCGGAGGGGTCACACTCAGCCTGGAGATACAGGAGACACACCTGATTCTTGATCTTAAGACTGACCCTCAGCCAAACGCAACCAGCTGGACTCTGATGTTGCCTCAGGTTGTATCTGATGGTGAATGGCACACAGTAGAAGCCGTACTTGGAGAGGGTACCCTGCTGCTGCAGCTGCTGGAGCCATGCCAGGGTGGACAAAACTGTGGTACAACAGCCCAAGTAAAGATCGGCGCCCTTGAGCTGGAGTCAGCCCTACTAAGCACCTTTGTTGGAGGATTGGATGAGGGAGGGAGCTCCAGATCATTCATCGGCTGCATGAGGGACTTGCTCGTGGACTCGCAGCTGATGATACCGGAGGACTGGTTGAGCAGCTCAGCTGTAAATGTTGTGCAGGGCTGTAGCCATCAT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa159
Status:
Confirmed mutation in F2 line
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000089774 Essential Splice Site 896 1428 7 13
ENSDART00000141006 Essential Splice Site 896 1428 7 13
Genomic Location (Zv9):
Chromosome 22 (position 24383929)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 23488815
GRCz11 22 23515379
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ATCGCGTTGTGAAAGTTACTGCAGGCTGCACCAGTGATGACACTTGCTCA[G/C]TAAGTTACAATGAGAAGTCTCATGAGATTTCAACTGCAACTGTACAACGA
Long Flanking Sequence:
CCATCAATGACGAACCTGACTCGGAAACACTTCATCTGTCCATGTTCTTGCGTACTCGAAAAGACTCTGGTCTTTTGGTGCTGCTGGCCAACAGCACCTCTGACTACTTGCAGATGTGGCTGGAAAAGGGAAAACTGACAGTTCAAGTCAACAACTTGAAGACTGTGACTGGTGAAAGGGTGCTTAATGATGGTGAGAGACATTTTGTCAGTGTCACCATCGAGGATGGCATGATGACTCTGCAGGACTCGGATCATGAATTCGAAGCAACATATGTTCAACCTGTTTCCATTCAGTTTGGGGATACGATCAATGTCGGTGGCCTGTTTGATGTACAAGCCTTAACTGCGTTTGGTGGACATTTTAAAGGTTGTCTACAAGACTTGCAGCTTAATGAGAAGAAGCTTGAGTTTTTCCCAATTGATACTTCTGCGATGTCGTACAAACCCGATCGCGTTGTGAAAGTTACTGCAGGCTGCACCAGTGATGACACTTGCTCA[G/C]TAAGTTACAATGAGAAGTCTCATGAGATTTCAACTGCAACTGTACAACGATTAGATAACACCAGATCTGGCAGCTACTGTATCTGGAAAAAAAGATCAGCTTATCTCATTTGGCTCTCGGTTGTCATGCTTAAATCCTTACATTCATGACATAAGAAACTAATCTAAATAACAGAAGGCAACAGAAATTGTTATGATTTGATTGAACGTTTTTAAGTGAGTACATAAAAAATGCTATAATCAAATAAGCTAAGCTTTTATATATTTATTTATAGATATATAAGTAAAGTTTCCACTAACCATGCCTCAATGTAGTTAGAAAACTTGTTCTAAGTGGTTGTTAGGTAGGCAGTTGCTAAGGCATTGCTAGGGTGTTGCTAGGCAGTTGCTAAGACATTGCTTAGAGGTAGCTAGAGTTTTCTGAGTGATTGTTAGGGTTTTCTTGTTGGTTGGCATGGTGTTCTGAGTGGTTGCTAGGTGGGTGCTAAGGCATTGCTAGGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa24173
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000089774 Nonsense 987 1428 9 13
ENSDART00000141006 Nonsense 987 1428 9 13
Genomic Location (Zv9):
Chromosome 22 (position 24386577)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 23486167
GRCz11 22 23512731
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GGCTGATATCCCGCCATCTGACCAGTATTGTCTTTAATATCCGTACACGT[A/T]AGCGCAATGCCATAGTGTTGCATGCAGAGAGTGGATCAGAGTTTGTAACT
Long Flanking Sequence:
AATAATCATTTTAATATTAACTTAATAATAATCTTTTCATTACAGAAAAATCCTTGCCAAAATGGTGGCATCTGCTTTTCTTCATGGGATGATTTTACTTGCAACTGCCCTCCTAACACATCAGGACAACACTGTGAGGAGGTGAGCTGGTGTGACCTCAACCCGTGCCCACCACAAGCAATATGCCGGGCCCTAAACCAGGGCTATGAATGTGAGTATTTTATGACACCTAATCTCATGTGTATGGAACTCGACTTCTTAATTCAAGTCAAGGGCTATAAATTGTAGCAAATTTGCTGAAAACGTGTTGTAAGCCTCAAATGAGATTGTATTGCAAATAGTTATCTTCATCCAAGAAGTTACATCTAAACTATTTCTGCCTTTATTTCTATGCAGGCATTTCAAACGTGACTTTCCAGGAGAACACCACACTTGTATACCAAGGCAATGGGCTGATATCCCGCCATCTGACCAGTATTGTCTTTAATATCCGTACACGT[A/T]AGCGCAATGCCATAGTGTTGCATGCAGAGAGTGGATCAGAGTTTGTAACTGTATCTCTTCAAGATGGATTTCTGGTTCTTGAGCTTCTAAGTGGACCTACTACTTCATCCTCATTGTCACCAGTAACCCTGCACAGCCCAAGGGTAGTCGCTGATGGGGAATGGCATGTTATAGAGCTGTTAATGGCCACTCCAGGGTCTAACAGCTCCCACTGGATTATGGTCCCCCTAGATGAAAAAGATGAGCCTACTAAATCAGACTCTATGACCGGAAATCTAGACTTCCTCAGAGAGAGCGTGTACATCATGCTAGGAGGACTAGGCCCTGATTCTGGCTCCAATCTCATTGGTTGCTTGAGTAATGTTGAGATTGGTGGAATCGTGCTTCCGTATTATGGACAGACTGAGGTGAGATTTCCACGCACACAGGAAGAAATGTTCAATAAGATATCCGAGGAGCCTGTTCAAACCGGCTGTTTCGGGGAGGTGGTGTGTGAGCCC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa24174
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000089774 Nonsense 993 1428 9 13
ENSDART00000141006 Nonsense 993 1428 9 13
Genomic Location (Zv9):
Chromosome 22 (position 24386596)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 23486148
GRCz11 22 23512712
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GACCAGTATTGTCTTTAATATCCGTACACGTAAGCGCAATGCCATAGTGT[T/A]GCATGCAGAGAGTGGATCAGAGTTTGTAACTGTATCTCTTCAAGATGGAT
Long Flanking Sequence:
ACTTAATAATAATCTTTTCATTACAGAAAAATCCTTGCCAAAATGGTGGCATCTGCTTTTCTTCATGGGATGATTTTACTTGCAACTGCCCTCCTAACACATCAGGACAACACTGTGAGGAGGTGAGCTGGTGTGACCTCAACCCGTGCCCACCACAAGCAATATGCCGGGCCCTAAACCAGGGCTATGAATGTGAGTATTTTATGACACCTAATCTCATGTGTATGGAACTCGACTTCTTAATTCAAGTCAAGGGCTATAAATTGTAGCAAATTTGCTGAAAACGTGTTGTAAGCCTCAAATGAGATTGTATTGCAAATAGTTATCTTCATCCAAGAAGTTACATCTAAACTATTTCTGCCTTTATTTCTATGCAGGCATTTCAAACGTGACTTTCCAGGAGAACACCACACTTGTATACCAAGGCAATGGGCTGATATCCCGCCATCTGACCAGTATTGTCTTTAATATCCGTACACGTAAGCGCAATGCCATAGTGT[T/A]GCATGCAGAGAGTGGATCAGAGTTTGTAACTGTATCTCTTCAAGATGGATTTCTGGTTCTTGAGCTTCTAAGTGGACCTACTACTTCATCCTCATTGTCACCAGTAACCCTGCACAGCCCAAGGGTAGTCGCTGATGGGGAATGGCATGTTATAGAGCTGTTAATGGCCACTCCAGGGTCTAACAGCTCCCACTGGATTATGGTCCCCCTAGATGAAAAAGATGAGCCTACTAAATCAGACTCTATGACCGGAAATCTAGACTTCCTCAGAGAGAGCGTGTACATCATGCTAGGAGGACTAGGCCCTGATTCTGGCTCCAATCTCATTGGTTGCTTGAGTAATGTTGAGATTGGTGGAATCGTGCTTCCGTATTATGGACAGACTGAGGTGAGATTTCCACGCACACAGGAAGAAATGTTCAATAAGATATCCGAGGAGCCTGTTCAAACCGGCTGTTTCGGGGAGGTGGTGTGTGAGCCCAATCCCTGCCTGCATGGAG
Associated Phenotype:
Not determined