ZMP

btk

Ensembl ID:

ENSDARG00000004433

ZFIN ID:

ZDB-GENE-070531-1

Human Orthologue:

BTK

Human Description:

Bruton agammaglobulinemia tyrosine kinase [Source:HGNC Symbol;Acc:1133]

Mouse Orthologue:

Btk

Mouse Description:

Bruton agammaglobulinemia tyrosine kinase Gene [Source:MGI Symbol;Acc:MGI:88216]

Alleles

There are 2 alleles of this gene:

Allele Name	Consequence	Status	Availability
sa13221	Essential Splice Site	Available for shipment	Available now
sa15417	Nonsense	Available for shipment	Available now

Mutation Details

Allele Name:

sa13221

Status:

Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Order Allele From ZIRC
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Mutation:

T > A

Consequence:

Essential Splice Site

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000009758	Essential Splice Site	298	660	10	19

Genomic Location (Zv9):

Chromosome 14 (position 40402353)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	14	38565587
GRCz11	14	38905901

KASP Assay ID:

None (used for ordering genotyping assays)

KASP Sequence:

CTGCAAGAACATCAACCGCAGTCAGGCAGAAAATTTACTAAAAACAGAAG[T/A]AAGTATGGAGCCGTGGTGGMACAATRACATGATTGGTTTATTAATGTGTC

Long Flanking Sequence:

GTTTTTTTCCAAATTAAAATTTGCTTTTTTTTTCCAGCCGAAATAAAACAAATAAGACTTTCTCCAGAAGAAAAAATATTATAGGAATTACTGTGAAAATTTCCTTGCTCGGTTGAACATCGTTTGGGAAATATTCATTCATTCATTTTCTTTTCGACTTAGTCCCTTTATTAATCTGGGGTCACCACAGCAGAATGAACCGCCAAATTATCCAGCATATGTTTTAAGCATAGACTGTTTTAAGCAGCGGATGCCCTTCTAGCTTCAACCCATTGCTGGGAAACATCCATACACACTCATTCACACTCATACACTACGGCCAATTTAGCCTAAAGAAAACAAAAATTGATAGGAGGGCTAATAATTATGACTTCAACTGTCCATTCAGCAACATTTTGAACCTTTCAAACTTTTTTAATCATGAATTTTCTCTCAATCTCACAGTTGGTACTGCAAGAACATCAACCGCAGTCAGGCAGAAAATTTACTAAAAACAGAAG[T/A]AAGTATGGAGCCGTGGTGGCACAATAACATGATTGGTTTATTAATGTGTCTGTAACTTTTACATTGTAATGATTATTTAAATGTGGGACAACCAGGAGAGTAATTTCTTCTGGAGACTTCAAAATCCCCCCTGTATTAGGCTTAGACAATCATATAGTTTGTTTTAATATTATTATTAACATATGAAGAGTTTAGATGCAAAAACCTATAAGTGCCGTCTGAAATGTCCATCAAAAATGAGCATTTTTGTCAGCCTCCTTTGTTTATGTTGAGATATTTCACTTTAAAGACCATAAAAAGGAATTACTATTTGCCATAAAAGTGATACTACTAAACCCACACACAGGAGCCTGATCAAAACGCTCACTCTAAAACAAAATTTCAGACGGCATTTAGAGGTTTTTGCATCTGAACCCTTCATATTATTATATTTTACAGAATACACCTGTTGATGTTAGTCTAATGGTTTGTGCTGCACAGAAAATGATCATAAAGGGGGT

Associated Phenotype:

Not determined

Mutation Details

Allele Name:

sa15417

Status:

Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.

Availability:

Order Allele From ZIRC
Order Allele From EZRC

Mutation:

T > A

Consequence:

Nonsense

Transcripts:

Transcript ID	Consequence	Amino Acid Affected	Amino Acid Total	Exon Affected	Exon Total
ENSDART00000009758	Nonsense	462	660	15	19

Genomic Location (Zv9):

Chromosome 14 (position 40393020)

Other Location(s):

Assembly	Chromosome	Position
GRCz10	14	38556254
GRCz11	14	38896568

KASP Assay ID:

None (used for ordering genotyping assays)

KASP Sequence:

TTNCKGTAAACCTCTAGGAAACTCTGTCACGGAAACCTGGTACAGCTCTA[T/A]GGTGTGTGCACRAAACAAAGACCCATMTACATAGTCACAGAATATCTCGC

Long Flanking Sequence:

TATTCATTTAATCATTTTCCAAAATCTCTATTCTAGAGGACGTCACCGCGAAATGAACCACCAACTATTCCAGCATATCTTTTACACAGCAGATGCCCTTCCAGCTACAATCCAGTTCCGTGAAACACCCATACACTATTCAAACATACACTACGGCCAATTTAGTTTATTCAATGTACCTACAGCTCATGTCTTTGGACTGTGGGGGAAACTGGAGCAACCAGAGGAAACCCACACGAACACGAGGAGAACATGCAAACTCCCCACAGAAATGCCAACTGGTCCAGCCGAGATTTGAACCAGCAACCTTCTTGCTGTGAGATGACAGTGCTAACCACTGATCTACAGTGCTGCCCCAGAGTTTAATTTGTTGGCAAAAATGACTGCATCTTATAAACATTATTATATCTTATTTTCATTCATGTTTTTATCAGTAATATATAATTTCTTTTGCGGTAAACCTCTAGGAAACTCTGTCACGGAAACCTGGTACAGCTCTA[T/A]GGTGTGTGCACGAAACAAAGACCCATCTACATAGTCACAGAATATCTCGCAAATGGATGTCTGCTGAATTACTTGCAGGAGGGTCTCTTAAACCCCACGAGTATTGCGCTTCTTGAGATGTGCAAAGATGTCAGCGAGGGCATGAAATACTTAGAGGCCAATCAGTTCATCCATAGAGACCTGGTTTGTATAATATTCACTGCCAATCGGAAGAGACATTTTACCATCAACATTTCTAAAATCCTTTGTTTTTGTTTTTGTCCTGCCAGGCTGCAAGGAACTGTTTAGTGGACTCAAATGGAACAATTAAAGTGACTGATTTTGGATTGTCAAGGTAATTGGATGAAAAGTATTTAAAGAGACCATGTGATCATATGATATAATTTGTCATGTTCCTTTTACTTAATGTGTAATGAATCTGCGCGTGTATGAATGTGTGTGTGCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAAACACTTCA

Associated Phenotype:

Not determined