Busch Lab

ZMP

cdk12

Ensembl ID:
ENSDARG00000063726
ZFIN ID:
ZDB-GENE-081104-294
Description:
Novel protein similar to H.sapiens CRKRS, Cdc2-related kinase, arginine/serine-rich (CRKRS) [Source:
Human Orthologue:
CDK12
Human Description:
cyclin-dependent kinase 12 [Source:HGNC Symbol;Acc:24224]
Mouse Orthologue:
Cdk12
Mouse Description:
cyclin-dependent kinase 12 Gene [Source:MGI Symbol;Acc:MGI:1098802]

Alleles

There are 3 alleles of this gene:

Allele Name Consequence Status Availability
sa1307 Nonsense Available for shipment Available now
sa29141 Nonsense Mutation detected in F1 DNA Not yet available
sa23419 Essential Splice Site Available for shipment Available now

Mutation Details

Allele Name:
sa1307
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000093402 Nonsense 250 1293 1 14
ENSDART00000143222 Nonsense 102 688 1 7
Genomic Location (Zv9):
Chromosome 19 (position 5482053)
Other Location(s):
Assembly Chromosome Position
GRCz10 19 4941364
GRCz11 19 4857850
KASP Assay ID:
554-1222.1 (used for ordering genotyping assays)
KASP Sequence:
AGYGTGCGTTCATCCAAATCTCGCAAAGAAAAGAGAAGGAACGAGGAGTA[T/A]GAGGAGGMCCGGAGCCATCGAAAGGCCGCAAAGAGTCGCAAGTCTAGCCC
Long Flanking Sequence:
GTGGAGTACGACGACATCAGCTCGGATTCGGACACGTTCCTTGACTCCCCCGCCACCGGGAACCCGGTGGACACCAGAGACGCCGAACAGCTAGATCTGTCGGACTACGGTGAGGTGGTGGCGGGGGTCGCCAAAGAGAACCGGACTCATAAACGCAAGCGCTCCCGGAAGAAATCCAAAGACCGGCATCGGGTCAGGGAGTCTGCGGAAAGACCAGTAGGGGCCAAAAAGAGCATCAAGGACCGGGAGAGGGTGAGCAAAGAGAGCCGAAAGAAGGTTAAGGAGAGGGCTAGTCCAGTCGCGTGCCTTGCTGCTTCATCATCCAGACGCTCCGGTGAGACCGGTGCCAAAAAGCTCGGCGGCGGCGAATCGGTGTCCTCCAGCGCGGTGCAGTCAGCTGTCAGCCTGGGCAGCAGCGCCTCCTCCGCATCTTCCTCCATCAGTAAGGAAAGCGTGCGTTCATCCAAATCTCGCAAAGAAAAGAGAAGGAACGAGGAGTA[T/A]GAGGAGGACCGGAGCCATCGAAAGGCCGCAAAGAGTCGCAAGTCTAGCCCTAAAGGGAAAAGCCAGTCCCGGAGGACCGTGGTGGACAGTCCTTCCGTTGCGGAGCTCGAGAACAGTTACTCCTCCAAACGCAAGGCCGCGAGCCCGAGCCCGTACAGAGAGCCGCCCAGGCGGAGCAGACAGAGGTCCGAGAGCCCCTACGGGAGAAGGAGGTCTTCCAGCCCTGAGAAGGATGGGAGTCCGTATGTGAGCAGAAAACACTCACCTGGAAGTCCTTACGCGAGCAGACGCTCACCCAGCAGCAGTCCAGTGTCCAGGTGTGTGCTCACTACATATTAAACGCACAGTTCACCCTAAAATTATAACGCTGTCATCATTTACTCACCTTTTACTTGTTTCAGGCCTTTGAGTGTCCTTCTTCTGTTAAACACTTAAAAAATAATTTTTGCTGTAACCATTGACTCCCATAGTATCTGTTTTTCCTAACATGGAAGTCTGTG
Associated Phenotype:
Normal
Stage Entity Quality Tag
Larval:Day 5
ZFS:0000037		 whole organism
ZFA:0001094		 quality
PATO:0000001		 normal
PATO:0000461

Mutation Details

Allele Name:
sa29141
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000093402 Nonsense 728 1293 5 14
ENSDART00000143222 Nonsense 580 688 5 7
Genomic Location (Zv9):
Chromosome 19 (position 5502949)
Other Location(s):
Assembly Chromosome Position
GRCz10 19 4962260
GRCz11 19 4878746
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AAAAAGAGGGTTTCCCCATCACCGCCATCAGGGAAATCAAGATCCTGAGG[C/T]AACTCAACCATCGCAGCGTGGTCAACATGAAAGAGATCGTCACTGACAAA
Long Flanking Sequence:
AACATGGTACATTAACTACATAACAAGAAAGAAGCATTTAATGGGGTAGAAAATGCACATATTTGCTCACCAGGGTTTGAAGGGAATTGGCAATTTCTCCTCAACGTTTTTTTAAACTTTCTGTATGAAACTTCAAACAGACCCGGGTGCTCCTGTCAAACCTCCACTAGTTTTTCCTCCATTTCTTGGGTCTAAATAAACCGAAAATAAGCGCTTTCAGCAGTTTCAGCTTAGGGACAAGTGCGTTTAGAATTTTCGCTTTTAGTTGAACTTTTGTTTTGGTGCATCCCAACTTATCATGACTCTCACTAATCACGCTATTCTATATCTGAGGCAGCTAACTTTGGTATAGTGTTTACAAAAAAAAAGACAACATGCTCACAACCTCCTTTTTTGTTTTGGTCTTTAAAGGAGAGCTGGTGGCATTGAAAAAAGTGCGACTGGATAACGAAAAAGAGGGTTTCCCCATCACCGCCATCAGGGAAATCAAGATCCTGAGG[C/T]AACTCAACCATCGCAGCGTGGTCAACATGAAAGAGATCGTCACTGACAAACAAGACGCACTGGACTTCAAAAAGGACAAAGGTCTGGCTAAATGCGTTTGCACGCGTGTTTACATTGTACTTTCAGTTTAAATAAGATGTGTTATTTGCCATTATCCTCCTTTTTGAATGTTTTGTTAACACTTAAATTATATTAAGTAACAATAATGCTAACAACAAACCATTAGCTAAGACGATTTGCTCAAACAGCTAATTAGCTGCTTATTAATAGTAATGTAGTAGTTAAGATGCGTAATTTGCAGTTATCGTCCTTTTAGAATTTCTTTCTGTAACTAAATTATTTTGTCACAATTCATGCTAACAAACCATTAGCTAAGACTATTAGCTCAATAAACCGCTTAATAGCTGCTTATTAATAGTAAGATGGTAGTTGAGTAAGATGTGTAATTTGCCATTATTCTCCTTTTCGAGTTTGTTTCGGTGACACTAAATTATTTTATG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa23419
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000093402 Essential Splice Site 897 1293 10 14
ENSDART00000143222 None None 688 None 7
Genomic Location (Zv9):
Chromosome 19 (position 5509766)
Other Location(s):
Assembly Chromosome Position
GRCz10 19 4969077
GRCz11 19 4885563
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GAAAAGGGCTTCAGTTGAAATGCTGTTTGTCTTCTTTTCTCCCCCGATCA[G/A]TCGTTTGTGTGGTAGTCCATGTCCTGCTGCTTGGCCAGATGTAATCCGGC
Long Flanking Sequence:
AGATCATTTAAGCGAGCTACGAAGAACAGACCCCTGTTGTTCATATCGCAAAGAAAACAAAATATGCAGTCCTAATTGATACAGTGTGTGTGTGTGTATAATTGTGAGTTGATGTTCTTTTCCAGTCGACCGTACACTAATAAGGTGATCACACTGTGGTATCGCCCGCCTGAGCTGCTACTGGGGGAGGAAAGATACTCACCTGCTATTGATGTCTGGAGCTGCGGGTGAGACAGAAGTCTGATTGCCATCATCTCATTACATTTACACCCAAAGTGATTTAAAATAGTAATATTTTTTTTTTGTGTGTGTGCTTTTGTTTAAAGGTGTATTTTAGGCGAGCTCTTCACTAAGAAACCAATTTTCCAAGCCAACCAAGAGCTTCTCCAGCTTGAGCTGATTAGGTGTGTTTGGATGTGTGTTTTTGTCAGTCTAATGCTGAAGGATGGAGAAAAGGGCTTCAGTTGAAATGCTGTTTGTCTTCTTTTCTCCCCCGATCA[G/A]TCGTTTGTGTGGTAGTCCATGTCCTGCTGCTTGGCCAGATGTAATCCGGCTGCCGTACTTCAATACCATGAGACCCAAGAAACAGTACAGGCGACGCTTACGAGAGGAGTTCTCTTTGTAAGTTCAACCTGATTCCTAAAACACATCCACTGCGAACATAACAGACTGTTCGGTTAATGATGGAGGTTTCTTTGACGAAAAATACCGTAAATTATATATATTGTGATTTATATTTTACAATATTTGAGTGTGTTTTCAAATGTCATTTTAATCCTGTGATGCAAAACTTTGTGTTGTTACTCCAAACTTAGTGACACGTGAATGTTGATCATTTCAAGAACTATTTCTCATTGTTATTAATGTAGAAAACAGTGCTGATTAATAGCTTTGATTAAACATTTTTCAGGATGCTTTGAATCGTGTCCTGAGCAAACTTCACAAACGCTGCATCCTTAATAGTTTGACACTGCTGTGATTTGGCTTTAAATGCATAAATACTC
Associated Phenotype:
Not determined