ZMP
ptpn22
Ensembl ID:
ZFIN ID:
Description:
tyrosine-protein phosphatase non-receptor type 22 [Source:RefSeq peptide;Acc:NP_001092890]
Human Orthologue:
PTPN22
Human Description:
protein tyrosine phosphatase, non-receptor type 22 (lymphoid) [Source:HGNC Symbol;Acc:9652]
Mouse Orthologue:
Ptpn22
Mouse Description:
protein tyrosine phosphatase, non-receptor type 22 (lymphoid) Gene [Source:MGI Symbol;Acc:MGI:107170
Alleles
There are 7 alleles of this gene:
| Allele Name | Consequence | Status | Availability |
|---|---|---|---|
| sa12441 | Essential Splice Site | Available for shipment | Available now |
| sa37721 | Nonsense | Mutation detected in F1 DNA | Not yet available |
| sa9634 | Essential Splice Site | Available for shipment | Available now |
| sa11960 | Essential Splice Site | Available for shipment | Available now |
| sa24347 | Nonsense | Available for shipment | Available now |
Mutation Details
Allele Name:
sa12441
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
A > T
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000087343 | Essential Splice Site | 97 | 905 | None | 30 |
| ENSDART00000103869 | Essential Splice Site | 97 | 130 | None | 4 |
| ENSDART00000129280 | Essential Splice Site | 97 | 888 | None | 29 |
Genomic Location (Zv9):
Chromosome 23 (position 26441918)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 23 | 26228038 |
| GRCz11 | 23 | 26154579 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
GCATTCGAGAGGATTTGGGAACCACTTGTCMTGTATTCTGTATTTATTTC[A/T]GGGTGTTTCAGGCTCTAAAGCATATATTGCCACCCAAGGGCCACTGTCAA
Long Flanking Sequence:
TTTAACTGTTTTCTCGCTAGTAAAGCGTTCAGTTTTTCCACTCACAAAGTCCACCATGTAAATAGCAACTGTGCCATAATGCGATGGAACTGACTTTTCAAAGGGAATGTGAGATGAGACTCTAATAGGTTTAATGCATATTATGCTCAAAACACACCAATAACCCATTAAGAGAATAAGCACAACCCTGTTATACCATGCGCCAGGGCGCAAACTGTATTTTTCCATCCTTCAAATAACAAAACGGGATTCGGACACGACCTTAATGCTTTTGCATTGTGCTCTTTAGACTTTGCACTTAGATTGTTAAAATAGACCCTTTGATTTTAGTTAAATAGACCAACTTTTTAATTGCAAAAACAAGAATGTATCATTTTTAGCACTTCAACTACACAGATCCAATTTAACAGAAAATGTAATGCTTAAACAATCACTGACACGTTATTAGTGGCATTCGAGAGGATTTGGGAACCACTTGTCATGTATTCTGTATTTATTTC[A/T]GGGTGTTTCAGGCTCTAAAGCATATATTGCCACCCAAGGGCCACTGTCAAACACTGTGCTTGACTTCTGGAGAATGATATGGGAATACAACATAAAGGTAAACGCTTGCCCTTATAGCGTATGACCATGTCACACGCATTCCATTTACTTTAGAAAACCAGTTTGACCTGCTAGATAAGCTTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCAAGCCAAACATTTGTCATGAATGCCTCTATAATAATTCAATGTCTCTTCACAGGTTATCGTGATGGTTTGCCGAGAGTTTGAAATGGGCAGGGTAAGTTCTAACTGACACGTGTGTTAGGGGGAAATGTTGTCAGTCACTCTGTCTTAAAGTAAACATTTTTTATTAACCACATCCTCTTGGCTCAGAATGGTGAAGCATTGCATCAAGCATGACAT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa37721
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000087343 | Nonsense | 102 | 905 | 4 | 30 |
| ENSDART00000103869 | Nonsense | 102 | 130 | 4 | 4 |
| ENSDART00000129280 | Nonsense | 102 | 888 | 4 | 29 |
Genomic Location (Zv9):
Chromosome 23 (position 26441935)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 23 | 26228055 |
| GRCz11 | 23 | 26154596 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GGAACCACTTGTCATGTATTCTGTATTTATTTCAGGGTGTTTCAGGCTCT[A/T]AAGCATATATTGCCACCCAAGGGCCACTGTCAAACACTGTGCTTGACTTC
Long Flanking Sequence:
TAGTAAAGCGTTCAGTTTTTCCACTCACAAAGTCCACCATGTAAATAGCAACTGTGCCATAATGCGATGGAACTGACTTTTCAAAGGGAATGTGAGATGAGACTCTAATAGGTTTAATGCATATTATGCTCAAAACACACCAATAACCCATTAAGAGAATAAGCACAACCCTGTTATACCATGCGCCAGGGCGCAAACTGTATTTTTCCATCCTTCAAATAACAAAACGGGATTCGGACACGACCTTAATGCTTTTGCATTGTGCTCTTTAGACTTTGCACTTAGATTGTTAAAATAGACCCTTTGATTTTAGTTAAATAGACCAACTTTTTAATTGCAAAAACAAGAATGTATCATTTTTAGCACTTCAACTACACAGATCCAATTTAACAGAAAATGTAATGCTTAAACAATCACTGACACGTTATTAGTGGCATTCGAGAGGATTTGGGAACCACTTGTCATGTATTCTGTATTTATTTCAGGGTGTTTCAGGCTCT[A/T]AAGCATATATTGCCACCCAAGGGCCACTGTCAAACACTGTGCTTGACTTCTGGAGAATGATATGGGAATACAACATAAAGGTAAACGCTTGCCCTTATAGCGTATGACCATGTCACACGCATTCCATTTACTTTAGAAAACCAGTTTGACCTGCTAGATAAGCTTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCAAGCCAAACATTTGTCATGAATGCCTCTATAATAATTCAATGTCTCTTCACAGGTTATCGTGATGGTTTGCCGAGAGTTTGAAATGGGCAGGGTAAGTTCTAACTGACACGTGTGTTAGGGGGAAATGTTGTCAGTCACTCTGTCTTAAAGTAAACATTTTTTATTAACCACATCCTCTTGGCTCAGAATGGTGAAGCATTGCATCAAGCATGACATTTTTGTTTTGTTTATCT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa9634
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000087343 | Essential Splice Site | 308 | 905 | 11 | 30 |
| ENSDART00000103869 | None | None | 130 | None | 4 |
| ENSDART00000129280 | Essential Splice Site | 308 | 888 | 11 | 29 |
Genomic Location (Zv9):
Chromosome 23 (position 26449018)
KASP Assay ID:
2261-7832.1 (used for ordering genotyping assays)
KASP Sequence:
AGTTGCTGTTYGAAAGATATCTGGCAGCACTTGAAGCACCAAGTAACAAG[G/A]TYRGATGAGAACAAACTAAATACAACAAWGATGCCAAATATTACATTTCC
Long Flanking Sequence:
AAATAAAGCTGTATTTTCGTTGTGCCTCATACTCTTGGGACTCTTTGTGGATTTGCAGTGCGGGCTGTGGAAGAACAGGTGCATTGTGCGCCATTGACTACACCTGGAATCTACTGAAGAGACAGGTAAAAATTCAAAGCATCTTCATTAGACTGGCATAAAAATAAAGAGGACACAAAAGAGCACAAACATTTCTGACAAAAGATGTTCAGATGTTAATCTATATCTTGACAAAGTTTTGATCTTATTTGTTCTCCATTAGATAATACCAGAGGATTTTAGCATTTTTGAGCTGGTAAAGGGCATGCGCACACAAAGGCCCTCAGTGGTTCAGACTAAGGTAACCAAGTTTCTCTTTAAATTACTGACATCAATTTAAACTCCATTTGGCCTAATGATGATTCCTTTTTTCCTCAAAGGAACAATATGAACTAGTTTACAGAACAATTAAGTTGCTGTTTGAAAGATATCTGGCAGCACTTGAAGCACCAAGTAACAAG[G/A]TTGGATGAGAACAAACTAAATACAACAAAGATGCCAAATATTACATTTCCCACACATCACAGTAAATGAAAAAATAATGTTATCATTCATCAGGTGCCAGATTCCTCCTCTCCTGCCATGTTAAGCAGTGGAAGTGAACTCTCAGATATCAGCGATTTCAGCGATCAGGAACAAACTGAGCACAGGTTTGAGGAGATTTCTCCATTTAATACTATTTTATTCAGGTTTTTAAAAAGTAGCTTAACTACAAATAAACATACATTCACCATCTAATTATCTTCATCTTCTTTTTGTTTCTTTTTTCTTAATTTAAAATCTTCTTTTAAAAATTGCTTTTGTCTCCAAAATGAAATTTAAAGGTGGCCAACGTTTTGGAGTGCACTGACTTTTAGAGGGCCGGTGTCTTGCATAGCTTAGCTCTAACTTTCTTAAACACACCTGCCTGCAGGTTTCTAGTATACCTAGAAAGAGCTTGATTGGCTGGTTCATTCATTCATTCA
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa11960
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000087343 | Essential Splice Site | 844 | 905 | 27 | 30 |
| ENSDART00000103869 | None | None | 130 | None | 4 |
| ENSDART00000129280 | Essential Splice Site | 827 | 888 | 26 | 29 |
Genomic Location (Zv9):
Chromosome 23 (position 26459206)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 23 | 26244936 |
| GRCz11 | 23 | 26171477 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
CAAACAAAGGGRCAGAGAAAACTTCACTGGTCAGCAAAGCAAGGAGCAAG[G/A]TTCAACTTCTTAAGTCTCTWAATTTTGGAACATRTTGTAAAGKGTTTRAC
Long Flanking Sequence:
ATTTTTGTCAAATGTGTCTTTTTTTCACAGAGTGTCAGAGCAAAAGGTTCAAAACAAGGTAGGTTGGTGTTTCCATTGTGTCCTCCCACACCTCAACCACAATGTGTCATGCTCAAGCAAAGTTGCCCTCTCATGTACTCTGTAGTGTTTGTCACTGTGCGACAGAGATAAAGAGGGCATGCTATTATTGGTCGTCTGTGTACACAGCTGTGTTTAATTTTACAGAGCCTTTTTCTGTGGCTCCGCTGTCTCTGCCCGTCTCTGTAACCACGCCAACCATAGGCCAAGGTGAGTGACAGCACAAATCCTCTGACAGTGATGGACATCAGTTCACGAAAATGCATATGCAAGACCATATAACCTCAGTTTATTGCTCTTTTGCTAATAAAGTAGAGCACCAGATGGGATACAGCAATCAGTTAGCAGCAACCGGGCTATTGGAGAACCAGTCAAACAAAGGGGCAGAGAAAACTTCACTGGTCAGCAAAGCAAGGAGCAAG[G/A]TTCAACTTCTTAAGTCTCTAAATTTTGGAACATGTTGTAAAGTGTTTGACATGACAATGGCATTAAAAACATAAAGTTACAGTGCTCTGCATAATTGAGTACACCCCATTTTGAAAATTAATATTTGTAGTCATTTCTTAGTGAATTGGCAATGTATTTTAGTGCATTAAAACAAGTTTATTAAACTGATATATTTATTACAATTATATTTTAGTGACCAAATATATTTATAAATTGAAAGATAATACAATTAAATTCAGGCAAAATATTGCAAAAAAAATATATATATATTACAACCTACAAAATGTTTGCCTCTCTTGATTTTTCTTCTTTTCTAAATTTTTTCTATAACATATAAATTTAGGTGTACTAGTTTTTGGACTGTTATCATAAGTTATTTTGATAGATACGCTCCAGTATTGGCTTCAGTACATTGTATGGCTTCCTGTTAAAATATGAATTTCAAAGATAGATTTGTAAGGGGTGTGCTTATATATGCT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa24347
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000087343 | Nonsense | 854 | 905 | 28 | 30 |
| ENSDART00000103869 | None | None | 130 | None | 4 |
| ENSDART00000129280 | Nonsense | 837 | 888 | 27 | 29 |
Genomic Location (Zv9):
Chromosome 23 (position 26460595)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 23 | 26246335 |
| GRCz11 | 23 | 26172876 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TATGTGTTTCTTTTCTATTGCAGAGTTTCAAGCTTTTAAAAGGAAAACAG[A/T]AGCGTATGTATAATAAACTTTTCTACATTTCATGCTGCTTAAATCTGTTT
Long Flanking Sequence:
AAAAGTGAGATGCTGCATTCTTTTCTCACGTCAAGCATCAGATTGCATTGCTCTCCCAATGAATGCAATTTTTACACCCAAACAATGGGTTAAAAATGTAATTAAAAATCAGTTTGTTTTAGTTAAAATTTTGCCCATGCGATAAATAGGCACACCTGACTGTTGTGTTTGTGTATGTTGCAGCAAACTGCACATTTAATTATTGCACAATACATTGTGTCAGGTTAAATGCTACTGCATTTTGTGAAAGCTACTGCATCCTTTAAGAGCCTTTTTTCAGATTTTCTATTATTTTATCTACAGTATGTCATCATGCGCTACAAAGATGTGTGTCACATTGCACTTGCATCTTTCTGTGTAATTACAAAAATGTGGCATGCAATTTTTAAGAGCGAAAACCGGTTCTGGTTGAATAGTCTGTTGTGTAGAGACAGATCCTTGCAAATTCATTATGTGTTTCTTTTCTATTGCAGAGTTTCAAGCTTTTAAAAGGAAAACAG[A/T]AGCGTATGTATAATAAACTTTTCTACATTTCATGCTGCTTAAATCTGTTTAATAGAATTTAAATAAAATATACATTTGATGGATAAAAAGGTTTTAAAGTATGAAAATAAAAAAAGGTGATACAGTTGTATTTATTTCTGTCATTTACAAGTGTTTTGTATGAGCAAAGTATAAATACCAACGTTTTATGAATATTTGTTTTATATATAATTTGTTTTATATATAATATATATAATTTATATAATATATGTTTTCATGAATATTTAGAGAAAAAAGACCCTTTATTTATATTCATTTATTGATTTTCTTTTCGGCTTAGTCCCTTTATTAATCTGGGGTTGCCACAGCGGAATGAACCGCCAATTTGTCCAGCCTGTTTTTACACAGCAGATGCCCTTCCATCTGCAACCCATCTCTGGGAAACATATATATATATATATATATATATATATATATATATATATATATATATATATATATATAAAAGCAATATCACACGA
Associated Phenotype:
Not determined