ZMP
nalcn
Ensembl ID:
ZFIN ID:
Description:
sodium leak channel non-selective protein [Source:RefSeq peptide;Acc:NP_001017549]
Human Orthologues:
CACNA1B, NALCN
Human Descriptions:
calcium channel, voltage-dependent, N type, alpha 1B subunit [Source:HGNC Symbol;Acc:1389]
sodium leak channel, non-selective [Source:HGNC Symbol;Acc:19082]
sodium leak channel, non-selective [Source:HGNC Symbol;Acc:19082]
Mouse Orthologue:
Nalcn
Mouse Description:
sodium leak channel, non-selective Gene [Source:MGI Symbol;Acc:MGI:2444306]
Alleles
There are 8 alleles of this gene:
| Allele Name | Consequence | Status | Availability |
|---|---|---|---|
| sa30919 | Nonsense | Mutation detected in F1 DNA | Not yet available |
| sa41452 | Nonsense | Mutation detected in F1 DNA | Not yet available |
| sa21514 | Essential Splice Site | Available for shipment | Available now |
| sa11942 | Essential Splice Site | Available for shipment | Available now |
| sa18947 | Essential Splice Site | Mutation detected in F1 DNA | Not yet available |
| sa6116 | Nonsense | Mutation detected in F1 DNA | Not yet available |
Mutation Details
Allele Name:
sa30919
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000048469 | Nonsense | 10 | 1742 | 1 | 44 |
| ENSDART00000060066 | None | None | 384 | 3 | 14 |
| ENSDART00000135022 | None | None | 1717 | None | 43 |
| ENSDART00000142289 | None | None | 168 | None | 4 |
| ENSDART00000145204 | Nonsense | 10 | 409 | 3 | 13 |
Genomic Location (Zv9):
Chromosome 9 (position 32775660)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 9 | 31931606 |
| GRCz11 | 9 | 31742352 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AGGGTATGCCTGATCGCATGTTATGTGCAGTGCTGGAGCAATTTCAGCTT[T/A]ACTTTTCCCGTTGGTATGTGCGCTTTGTTTCAGTGAGTGTGTGATATCCA
Long Flanking Sequence:
TTCATCATGTTGTATGATGTTTGACGCAAGAAGGCCTGCCTGACCTTACTGGACATGACAGTTGGTTGATGTGGATTTGTTGCTTTTGTGTTGATATCACATGTAAAGGTCAGGCTTTCAGCTGTTGTGCGATGCAGCTTTCATTGGCCGGACTCTTTTCATAAACAAGCATTAAAGGCTAATGGTGTTCTTGCAGGACAGGCCTCAACTCAACAGGCCCCCATCAGCTGTCTTTCGTACTGAATTCAGTTCCTGTCTATGCCGGGGATGAATGCACCAATGAGGAGCCTGACCGTGAGTAACCTGGTCCCACGATCCCATCCGTCCATGACTCCGCCACTCAGTGTTGCATATATGCCTTGTCTGACGTGGTGGACATTATTTGTCGATATAATTGTACCCGTTAGGTACACCATATGCCATGTTGACTAACTGTTGTGTGTTATTTACAGGGTATGCCTGATCGCATGTTATGTGCAGTGCTGGAGCAATTTCAGCTT[T/A]ACTTTTCCCGTTGGTATGTGCGCTTTGTTTCAGTGAGTGTGTGATATCCATGTTTTTTTAATTATTGTCTTCGGTTAGAGTGGCTCTAGTGCCAGTAGTCTGTCGTCTGTTTTGCGTTGAAGATCCAGTGTGATCTTTGCACAAGGTAAGTCCGTATTTCTGTGTAGTCGACAGTCTGTGTTTTATGTACATCATACGCTTGATTGTGTTTAACGGTGGCTGTGCAACACTACAACACATATTGTCTGGTACCATACAAAGCTCTGTGTCCTCATATCGTTTGTACAGCCACAATGAACACACAGCTCAAATCTGTTTGCATGATACTGTTACTAGATGTTTCTGTGACACGATGCTTCTTCTGAGGTGTTTTATTTTCATTCCATTCAATTAGCGTCAAGGTTTTGCTAAAGTAAATTGCTTATCTTCTTTTAATATTTCATTCTGTAATTGAATTGCTCCAAACACATATTAAACAGAGGTAGCATTCAATAAGCAAT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa41452
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > A
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000048469 | Nonsense | 627 | 1742 | 15 | 44 |
| ENSDART00000060066 | None | None | 384 | None | 14 |
| ENSDART00000135022 | Nonsense | 602 | 1717 | 14 | 43 |
| ENSDART00000142289 | None | None | 168 | None | 4 |
| ENSDART00000145204 | None | None | 409 | None | 13 |
Genomic Location (Zv9):
Chromosome 9 (position 32704240)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 9 | 31860186 |
| GRCz11 | 9 | 31670932 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CTAGATCCTTCTGAGTCTTTTTGTTGCTGTTATTTTGGACAATCTTGAGT[T/A]GGATGAAGACCTGAAAAAGTTAAAACAGGTAAGTCATTATTCTTTTTATT
Long Flanking Sequence:
ATAACCATTTAGAATCTATTACTGAATCAATACTAAATTGTCTGCATCTGCAATGCGGTGCACTGAAGAAACAATATATATATATATATATATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATATACATATTTATATATATTTATATATATATATATATCATATTAAAGCCACTTCACTATGATTTTCTTTTGAAATGTTGAGTTAAGGAGTGACTGTTAAAAGAAATTTCTTCAAATTGTTTATCTGCTTTGTCCTGACAACAATCTGAATGCATATAAAGTAGATTTTGTCAAACTGTATTGAATAAAAATGGAATCTGTTTTGTTTTCTAGATCCTTCTGAGTCTTTTTGTTGCTGTTATTTTGGACAATCTTGAGT[T/A]GGATGAAGACCTGAAAAAGTTAAAACAGGTAAGTCATTATTCTTTTTATTTTGCTGATATACTACTCTGCAGATGTTTGGGGTTGTAAGCATTCTGTATGCCTCTAAAAGAATTATTTTATGGTCAACAACAGTAAAACCACTAGTTTATGTGAATATTATGGGTGCATCAATCATTTGTCTAATGATAACTAATAATTGCTTCTGGAACAGTGATTGATTTGCTGTGCTTATAAAGTTTTGCTGATGACACAAAAAGATGTGCACCTCTTGTCAATGTTTCTTTACATTGGTTTATTTTAAAAATTTACAAATGTATTCCTGTAATGGTAAAGCCGAAGATAGCAAAGCCAGGAAGATACCAAATGCAGGAAAACAGGCAAGAACTAAAACACAGGTATATTCTACAATGCGTAACTCCATTAGTGGACAACACCAGGAGAAGAAACAAAATACACACTAGAGAACAATGAACTAATCAACAGATAATGGCCAACAGAC
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa21514
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
A > T
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000048469 | Essential Splice Site | 730 | 1742 | 18 | 44 |
| ENSDART00000060066 | None | None | 384 | None | 14 |
| ENSDART00000135022 | Essential Splice Site | 705 | 1717 | 17 | 43 |
| ENSDART00000142289 | None | None | 168 | None | 4 |
| ENSDART00000145204 | None | None | 409 | None | 13 |
Genomic Location (Zv9):
Chromosome 9 (position 32665969)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 9 | 31821915 |
| GRCz11 | 9 | 31632661 |
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TGATCTGTGCATTGATCTGTGTACATATCTGTAAACCTCTTCTTCTTCCC[A/T]GCTACGAAAGTCAGTATTTAGCATCCGGGCTCGCAACCTAATGGAAAAGG
Long Flanking Sequence:
GACGTGAAGTCTCCTGTGTGTTTGCGTGTGCCACAGGGAGAGTTTCATGAAGCAGTTCATCGACCGACAGCAGCAGGACCCTAGCTGTCTGTTCCGTCGCCTTCCCTCAGCATCATCCTCGTCTTGCGACCATTCCAAACGCTCTGCCATTGAGGATAATAAATACATAGATCAGAAGGTAGCACATTCCATCACTCCTACAGTCTGCCCCCTCAATACACACAGGGACCAAACAATAATCTCATGAATGTTCTGAAAGGAACCGATCCATTTCCCACGCAACAAGACTCAAATAACCAGCAGTTATATAACAATATTTTCTTTATTACATTGGGATGTTTTTGTTTGCTAGTGTCAAAGTCAGATTTACCCACATAATAATAGTTGTTTGGAGATGTACACTTTTGAATTGTGCTGTGTATTGATCTGTGTATTGTGAATATGTGTATATGATCTGTGCATTGATCTGTGTACATATCTGTAAACCTCTTCTTCTTCCC[A/T]GCTACGAAAGTCAGTATTTAGCATCCGGGCTCGCAACCTAATGGAAAAGGAAATCACTGTCAACAAAATTTTGCGGTGAGCTTGTTTTTCTCCTTTTAATCACAGATCTTGTAGACATCAGGAATATTTTATTTTATTTTATTTTATTTTATTTTATTTTATTTTACAGTGAAATTAACTACCAACTAATAAATAAAAATTAGTTTATAATTAAGGCAAATATAGAGGAAATATGGCAAAATTTCAGGGAAATAAATATTTTATTTTATTTTATTTCACAACCCACAATTTTATAATTAAGGGAAATATTATGGGAATATGGCAAAATTTCATAGAAAAATATATTTTGTTTTATATTATTTATTTATTTATTTATTGTCTTTGTCCCTGATCCATCAGGGTTTGCCACAGTCAAATGAACCGCCAACTACTACTGTTTTACACAGCAGATGATCTTTCAGCCGCAATCAACCATCGAGCTGGGAATTATTTTAGTTTAT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa11942
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000048469 | Essential Splice Site | 1558 | 1742 | 40 | 44 |
| ENSDART00000060066 | None | None | 384 | None | 14 |
| ENSDART00000135022 | Essential Splice Site | 1533 | 1717 | 39 | 43 |
| ENSDART00000142289 | Essential Splice Site | 41 | 168 | 1 | 4 |
| ENSDART00000145204 | None | None | 409 | None | 13 |
| ENSDART00000048469 | Essential Splice Site | 1558 | 1742 | 40 | 44 |
| ENSDART00000060066 | None | None | 384 | None | 14 |
| ENSDART00000135022 | Essential Splice Site | 1533 | 1717 | 39 | 43 |
| ENSDART00000142289 | Essential Splice Site | 41 | 168 | 1 | 4 |
| ENSDART00000145204 | None | None | 409 | None | 13 |
Genomic Location (Zv9):
Chromosome 9 (position 32629202)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 9 | 31785148 |
| GRCz11 | 9 | 31595894 |
KASP Assay ID:
2260-2007.1 (used for ordering genotyping assays)
KASP Sequence:
ATGGAGCGTCTGCACAATGGAGGAGACGTCAYCTTTCATGATGTACTGAG[G/A]TTAGAAAAGAAAAAGCCTGCTATTAATTCTAGCACATAATTTTACCTTTA
Long Flanking Sequence:
GTAACCATTGAATTCCATATTAGAATAAACAAATACTATATAGGTCAATGGTTACAGGTTTCCAGCATTTTTCAGAATATCTTCTTTTTTTGTTCATCAGAATAAAGAAGCTCAAACAGATTTGGAATGAGTGAACATTGTGTAAATGATGAGAATTTTTAGTTTTGGATCAGTTTAAGGGATTAAACTGTTGCTAATGATAGTAATTATTTACAGTATTTATATAGAAACAGAGCAATAATCTGAGAATTGTCTTTTAGTGTTTAGTCTAGAAACTATTATTAGGATAAGGTTTGTTAATCCAGCATCTGCTATTACAATAAAATAAAATTTGTAACACAGGGAGTGATTCCGACCTCTCGGGTGAAGTTTCTGCTCCGTCTGCTGAGAGGTCGTCTGGAAGTGGATCTGGACAAAGACAAGCTTCTCTTTAAACACATGTGTTATGAGATGGAGCGTCTGCACAATGGAGGAGACGTCACCTTTCATGATGTACTGAG[G/A]TTAGAAAAGAAAAAGCCTGCTATTAATTCTAGCACATAATTTTACCTTTATAACGAATCAGACTACATAAGATCTACTGCGATAAGATCTTCTTACCCAGACAAAACAGCTAGCACTGAAAGGGTCATATTGTACCACCCTCACTGCTGTGTTGTTGATGTTCTGTGGCCCATATGAAGTCATGTATGATTGTGTGAATGTGTGTGTGTTTCAGCATGCTGTCGTATCGTTCAGTTGATATCCGCAAGAGTCTTCAGCTGGAGGAGCTGTTGGCAAGAGAGCAGCTTGAATACACTATAGAGGAGGAAGTGGCCAAACAAACCATCCGCATGTGGTTGAAGAAGTGCCTGAAACGCATCAGAGCCGTGAGTCCATACAAACACTCATCGTTCAATTCAGATGCTGGATGACTACAGAAGAGGATTAGCGCCTATCAATAATAATGATAAACAACCTTCTCAAGATTAATTGGCATTATAATGTGTGATTTGAAGAAAATT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa18947
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000048469 | Essential Splice Site | 1558 | 1742 | 40 | 44 |
| ENSDART00000060066 | None | None | 384 | None | 14 |
| ENSDART00000135022 | Essential Splice Site | 1533 | 1717 | 39 | 43 |
| ENSDART00000142289 | Essential Splice Site | 41 | 168 | 1 | 4 |
| ENSDART00000145204 | None | None | 409 | None | 13 |
| ENSDART00000048469 | Essential Splice Site | 1558 | 1742 | 40 | 44 |
| ENSDART00000060066 | None | None | 384 | None | 14 |
| ENSDART00000135022 | Essential Splice Site | 1533 | 1717 | 39 | 43 |
| ENSDART00000142289 | Essential Splice Site | 41 | 168 | 1 | 4 |
| ENSDART00000145204 | None | None | 409 | None | 13 |
Genomic Location (Zv9):
Chromosome 9 (position 32629202)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 9 | 31785148 |
| GRCz11 | 9 | 31595894 |
KASP Assay ID:
2260-2007.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ATGGAGCGTCTGCACAATGGAGGAGACGTCACCTTTCATGATGTACTGAG[G/A]TTAGAAAAGAAAAAGCCTGCTATTAATTCTAGCACATAATTTTACCTTTA
Long Flanking Sequence:
GTAACCATTGAATTCCATATTAGAATAAACAAATACTATATAGGTCAATGGTTACAGGTTTCCAGCATTTTTCAGAATATCTTCTTTTTTTGTTCATCAGAATAAAGAAGCTCAAACAGATTTGGAATGAGTGAACATTGTGTAAATGATGAGAATTTTTAGTTTTGGATCAGTTTAAGGGATTAAACTGTTGCTAATGATAGTAATTATTTACAGTATTTATATAGAAACAGAGCAATAATCTGAGAATTGTCTTTTAGTGTTTAGTCTAGAAACTATTATTAGGATAAGGTTTGTTAATCCAGCATCTGCTATTACAATAAAATAAAATTTGTAACACAGGGAGTGATTCCGACCTCTCGGGTGAAGTTTCTGCTCCGTCTGCTGAGAGGTCGTCTGGAAGTGGATCTGGACAAAGACAAGCTTCTCTTTAAACACATGTGTTATGAGATGGAGCGTCTGCACAATGGAGGAGACGTCACCTTTCATGATGTACTGAG[G/A]TTAGAAAAGAAAAAGCCTGCTATTAATTCTAGCACATAATTTTACCTTTATAACGAATCAGACTACATAAGATCTACTGCGATAAGATCTTCTTACCCAGACAAAACAGCTAGCACTGAAAGGGTCATATTGTACCACCCTCACTGCTGTGTTGTTGATGTTCTGTGGCCCATATGAAGTCATGTATGATTGTGTGAATGTGTGTGTGTTTCAGCATGCTGTCGTATCGTTCAGTTGATATCCGCAAGAGTCTTCAGCTGGAGGAGCTGTTGGCAAGAGAGCAGCTTGAATACACTATAGAGGAGGAAGTGGCCAAACAAACCATCCGCATGTGGTTGAAGAAGTGCCTGAAACGCATCAGAGCCGTGAGTCCATACAAACACTCATCGTTCAATTCAGATGCTGGATGACTACAGAAGAGGATTAGCGCCTATCAATAATAATGATAAACAACCTTCTCAAGATTAATTGGCATTATAATGTGTGATTTGAAGAAAATT
Associated Phenotype:
Not determined
Mutation Details
Allele Name:
sa6116
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
| Transcript ID | Consequence | Amino Acid Affected | Amino Acid Total | Exon Affected | Exon Total |
|---|---|---|---|---|---|
| ENSDART00000048469 | Nonsense | 1683 | 1742 | 43 | 44 |
| ENSDART00000060066 | None | None | 384 | None | 14 |
| ENSDART00000135022 | Nonsense | 1658 | 1717 | 42 | 43 |
| ENSDART00000142289 | Nonsense | 167 | 168 | 4 | 4 |
| ENSDART00000145204 | None | None | 409 | None | 13 |
Genomic Location (Zv9):
Chromosome 9 (position 32625545)
Other Location(s):
| Assembly | Chromosome | Position |
|---|---|---|
| GRCz10 | 9 | 31781491 |
| GRCz11 | 9 | 31592237 |
KASP Assay ID:
554-3849.1 (used for ordering genotyping assays)
KASP Sequence:
TGAGCCCCACTCTGTCAGACCGCAGTGGATACAGACAGGACTCTGCTGAC[C/T]GACCCCAGAGGAAGCTGGGACAGTGGAGACTTCCTGCAGGTCTAAAGCTT
Long Flanking Sequence:
CTGATTTGAGCAGGAAATCCCAATTAGGTGCATTCAGTCTCCGATGTGAACAAAGTCAAAGCTCTAAAACAGATGCACAGATAGGATAGAATTGCTTAGCTGCAGTCGCTTTGCTTTTACTGCAGTAGAATCAGACTGGATGCTGATATTAGACATGCCAGATGAGCTGAATAAAAACATCCTTCTCTTCCAGAAACAGCAGCAGTCATGCAGCATCATCCTCAGTCTGAGAGAGAGTCAACAGCAAGACCTGCGGCGGCTGCTCAACCCCCCCAGCATCGAGACCACCGTCCCCAGCGAAGACACCAACACACACAACCAGGACAATCCCACCCAGCCTGAGGTAAACAGAGCAGTGCGTATGCTTCTGTGTGCTCTTTAGTGTGCTGAAGTGCTTTGAACGCATGTTTCTGGTTGTGTCCCAGCAGAACAGCGGCCTGCAGACGTTACTGAGCCCCACTCTGTCAGACCGCAGTGGATACAGACAGGACTCTGCTGAC[C/T]GACCCCAGAGGAAGCTGGGACAGTGGAGACTTCCTGCAGGTCTAAAGCTTTTATTCTTAAAAATGAGGCATAGACTGTACAGTATAAAGTGTACTATACTAAATAAAGATTGTTTGTAACAGCCATATCTCATTTATTTTTCCAAAAATTGTCTACAACAGTATGATTGCAAAATTAAATATTGCAATTTTTCAAATGAACATTGTCTAATGAATGCCATAGAAGTGTTGCTCTGATCTATGTAATTACAGTAATATTAAAGGTGCTATAGAATTTACTGATACAGGGTTCAGGGCTGAAGTAAGCATTTATTTAATATAAAAATATATAAATATCTGTATTTCATCATATATATATATATATATATATATATATATATATATATATATATATATTTATTTATATTAGTATTGTAGATTCCCAAAGTGTATACTTTAAATTTTATTGTTGTTTCTTCATTTAATACTTAAGTAAGCATGGGGATTTTGACCATTATACAG
Associated Phenotype:
Not determined