Busch Lab

ZMP

apba1

Ensembl ID:
ENSDARG00000074328
ZFIN ID:
ZDB-GENE-070925-3
Human Orthologue:
APBA1
Human Description:
amyloid beta (A4) precursor protein-binding, family A, member 1 [Source:HGNC Symbol;Acc:578]
Mouse Orthologue:
Apba1
Mouse Description:
amyloid beta (A4) precursor protein binding, family A, member 1 Gene [Source:MGI Symbol;Acc:MGI:1860

Alleles

There are 5 alleles of this gene:

Allele Name Consequence Status Availability
sa11155 Nonsense Available for shipment Available now
sa41608 Nonsense Mutation detected in F1 DNA Not yet available
sa11749 Nonsense Available for shipment Available now
sa41609 Nonsense Mutation detected in F1 DNA Not yet available
sa41610 Essential Splice Site Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa11155
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000114483 Nonsense 83 971 1 12
ENSDART00000140511 Nonsense 83 960 2 12

The following transcripts of ENSDARG00000074328 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 10 (position 15812245)
Other Location(s):
Assembly Chromosome Position
GRCz10 10 15825552
GRCz11 10 15783671
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
CTAGTCGAGCTCCACCRCGTCATCGTAGGCGGCATGTTCCTGGTCAAGCA[C/T]AACGCAGGCGGCCCGAGAGTGGAGATTCAGAAGCTAGAGCTGGCCAGCAR
Long Flanking Sequence:
GTTGACATATCAAGATATGAGATTGTTGTTGTCATATCTCCTAGACACGTTGAAGATTTTAAAACTTATAGTTTACACCAGTTTCAGGCAGCTTATAGTTTTAAAATATTTTGCTATTATTTGCATCCCATACATTGCTTGATTTCCCCACACATATTGGGGGATATACTCCTCCCAAACCTCCTAATGTTTGTGTGTGTGTCATTCAGGCAGTTCAGCAGCATCTAGACAATGAGCAGTGAGTGGGTGGAGCCATGAGCCATAGGGAGGAGCCAGAGGAGGCAGGCCTCAGAGGACCTCCCCCTCATCGCAGCAAGCAGCCCAATGGGACTCCTTTAGAGGGGGGCCGTCCCAGATGGAGGCCATGCCAGCTGCACAATCCCGATGCAGAAAGCCAAGGCCAGCACCATCATCACTATCATCACCAAGCCCACCAGCATGCGTCTGGATCTAGTCGAGCTCCACCACGTCATCGTAGGCGGCATGTTCCTGGTCAAGCA[C/T]AACGCAGGCGGCCCGAGAGTGGAGATTCAGAAGCTAGAGCTGGCCAGCAACCCAAACCGGGGGCGTCAAAACACCATCGAAGTGGAGAGAGACTCTATCAGCACAGATACAGACAACAGCACAAAGATGAAGAACAACATGTCAAAACTCCTCCAAAAGAGCAAGCTTCAGAGCCATTGTTATCTCCAGATGATTCTTCTCAAGACTTGCTGACCCCTTCTCCTCAGGATGAACCAGTCACTGACGAACTGGATGAGAGCAGTCCAGATTTGTCCCATTCATCTGATACACAGATTAATCGTGATCCAGAACAAGAACAGGCAGAGTCTTCAGTGGATCAGCCGGAGGAGAATGTCCACCGTGAAGAATTCAAGAATCCATGTGAAGAGGAATTAGTAAAAGTGAACGAAGTTGAGGACTTATCCACACAGATTCCTGAGGAAGATTATGTCCCACCTAAGATTGCTTCAAAAAGTCGACCTGAAAGTAAAAGAACTAGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa41608
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000114483 Nonsense 124 971 1 12
ENSDART00000140511 Nonsense 124 960 2 12

The following transcripts of ENSDARG00000074328 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 10 (position 15812368)
Other Location(s):
Assembly Chromosome Position
GRCz10 10 15825675
GRCz11 10 15783794
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACCATCGAAGTGGAGAGAGACTCTATCAGCACAGATACAGACAACAGCAC[A/T]AAGATGAAGAACAACATGTCAAAACTCCTCCAAAAGAGCAAGCTTCAGAG
Long Flanking Sequence:
CATCCCATACATTGCTTGATTTCCCCACACATATTGGGGGATATACTCCTCCCAAACCTCCTAATGTTTGTGTGTGTGTCATTCAGGCAGTTCAGCAGCATCTAGACAATGAGCAGTGAGTGGGTGGAGCCATGAGCCATAGGGAGGAGCCAGAGGAGGCAGGCCTCAGAGGACCTCCCCCTCATCGCAGCAAGCAGCCCAATGGGACTCCTTTAGAGGGGGGCCGTCCCAGATGGAGGCCATGCCAGCTGCACAATCCCGATGCAGAAAGCCAAGGCCAGCACCATCATCACTATCATCACCAAGCCCACCAGCATGCGTCTGGATCTAGTCGAGCTCCACCACGTCATCGTAGGCGGCATGTTCCTGGTCAAGCACAACGCAGGCGGCCCGAGAGTGGAGATTCAGAAGCTAGAGCTGGCCAGCAACCCAAACCGGGGGCGTCAAAACACCATCGAAGTGGAGAGAGACTCTATCAGCACAGATACAGACAACAGCAC[A/T]AAGATGAAGAACAACATGTCAAAACTCCTCCAAAAGAGCAAGCTTCAGAGCCATTGTTATCTCCAGATGATTCTTCTCAAGACTTGCTGACCCCTTCTCCTCAGGATGAACCAGTCACTGACGAACTGGATGAGAGCAGTCCAGATTTGTCCCATTCATCTGATACACAGATTAATCGTGATCCAGAACAAGAACAGGCAGAGTCTTCAGTGGATCAGCCGGAGGAGAATGTCCACCGTGAAGAATTCAAGAATCCATGTGAAGAGGAATTAGTAAAAGTGAACGAAGTTGAGGACTTATCCACACAGATTCCTGAGGAAGATTATGTCCCACCTAAGATTGCTTCAAAAAGTCGACCTGAAAGTAAAAGAACTAGTCCTCTACGAGTAGATGTCCCACCATTTGCCACATCTCCTCACCAGATTATCAACAAACCTTTTTTTCAGTCTCCACGAAGCTTCCCTGAGAGTCTTCGAAGGTACAATTCTGATCCGAAGTCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa11749
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000114483 Nonsense 275 971 1 12
ENSDART00000140511 Nonsense 275 960 2 12

The following transcripts of ENSDARG00000074328 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 10 (position 15812821)
Other Location(s):
Assembly Chromosome Position
GRCz10 10 15826128
GRCz11 10 15784247
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
TTGCCACATCTCCTCACCAGATTATCAACAAACCTTTTTTTCAGTCTCCA[C/T]GAAGCTTCCCTGAGAGTCTTCGAAGGTACAATTCTGATCCGAAGTCATAC
Long Flanking Sequence:
ATCGAAGTGGAGAGAGACTCTATCAGCACAGATACAGACAACAGCACAAAGATGAAGAACAACATGTCAAAACTCCTCCAAAAGAGCAAGCTTCAGAGCCATTGTTATCTCCAGATGATTCTTCTCAAGACTTGCTGACCCCTTCTCCTCAGGATGAACCAGTCACTGACGAACTGGATGAGAGCAGTCCAGATTTGTCCCATTCATCTGATACACAGATTAATCGTGATCCAGAACAAGAACAGGCAGAGTCTTCAGTGGATCAGCCGGAGGAGAATGTCCACCGTGAAGAATTCAAGAATCCATGTGAAGAGGAATTAGTAAAAGTGAACGAAGTTGAGGACTTATCCACACAGATTCCTGAGGAAGATTATGTCCCACCTAAGATTGCTTCAAAAAGTCGACCTGAAAGTAAAAGAACTAGTCCTCTACGAGTAGATGTCCCACCATTTGCCACATCTCCTCACCAGATTATCAACAAACCTTTTTTTCAGTCTCCA[C/T]GAAGCTTCCCTGAGAGTCTTCGAAGGTACAATTCTGATCCGAAGTCATACCCTACCTTTTTCAACAATAATTATGCTTGTACAAGAAATGATAAAGAGTTTGATAGTCCTAGATCCCACGATGAAGGTGACCTCTCAGACTCTGAAGCCTATACAGATTCTTACCCAGAGTCTCATCCTAAAGACACAGAAACAGACCTTAACCCAGCCTTTGAAGAACCTCAAGCATATGAGATGAACTACAGCATGTCAATGGATGAATGCGATGACCAGCAGGATCTAGAGGAAGAGCCTAATCCACATAGTGCAGTGGGCTCCAGACTCCACCACTACGATGAGCAATCAGGAGATGAAGCTGAAAGTTTCGGCAGAAGCAGAGCCCATCTCAGGAAGACATCAAGCTCAACTAGCCTTCCATTGGAAGTTCATCCCCAAGATGACGAGACATCAGAAATGACTCAAAATTCAACAGACTTGCAGGAAGAAGTTGAGGACGTACCT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa41609
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > G
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000114483 Nonsense 329 971 1 12
ENSDART00000140511 Nonsense 329 960 2 12

The following transcripts of ENSDARG00000074328 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 10 (position 15812985)
Other Location(s):
Assembly Chromosome Position
GRCz10 10 15826292
GRCz11 10 15784411
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TCCCACGATGAAGGTGACCTCTCAGACTCTGAAGCCTATACAGATTCTTA[C/G]CCAGAGTCTCATCCTAAAGACACAGAAACAGACCTTAACCCAGCCTTTGA
Long Flanking Sequence:
ACTGACGAACTGGATGAGAGCAGTCCAGATTTGTCCCATTCATCTGATACACAGATTAATCGTGATCCAGAACAAGAACAGGCAGAGTCTTCAGTGGATCAGCCGGAGGAGAATGTCCACCGTGAAGAATTCAAGAATCCATGTGAAGAGGAATTAGTAAAAGTGAACGAAGTTGAGGACTTATCCACACAGATTCCTGAGGAAGATTATGTCCCACCTAAGATTGCTTCAAAAAGTCGACCTGAAAGTAAAAGAACTAGTCCTCTACGAGTAGATGTCCCACCATTTGCCACATCTCCTCACCAGATTATCAACAAACCTTTTTTTCAGTCTCCACGAAGCTTCCCTGAGAGTCTTCGAAGGTACAATTCTGATCCGAAGTCATACCCTACCTTTTTCAACAATAATTATGCTTGTACAAGAAATGATAAAGAGTTTGATAGTCCTAGATCCCACGATGAAGGTGACCTCTCAGACTCTGAAGCCTATACAGATTCTTA[C/G]CCAGAGTCTCATCCTAAAGACACAGAAACAGACCTTAACCCAGCCTTTGAAGAACCTCAAGCATATGAGATGAACTACAGCATGTCAATGGATGAATGCGATGACCAGCAGGATCTAGAGGAAGAGCCTAATCCACATAGTGCAGTGGGCTCCAGACTCCACCACTACGATGAGCAATCAGGAGATGAAGCTGAAAGTTTCGGCAGAAGCAGAGCCCATCTCAGGAAGACATCAAGCTCAACTAGCCTTCCATTGGAAGTTCATCCCCAAGATGACGAGACATCAGAAATGACTCAAAATTCAACAGACTTGCAGGAAGAAGTTGAGGACGTACCTGAAAAGCAAGATCAAATAACTGAGTCTTGCAAAGCTACGGGCGACGCTGTGTCTTTGGCCATCAGGGATATTAAGGAAGCCATCGAAGAGGTGAAGACCAAGACTGTGCGTTCACCCTACATGCCTGACAAGATCACTGAGCCGGTGTGGGTGATGAGACAAGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa41610
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000114483 Essential Splice Site 861 971 9 12
ENSDART00000140511 Essential Splice Site 850 960 9 12

The following transcripts of ENSDARG00000074328 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 10 (position 15831913)
Other Location(s):
Assembly Chromosome Position
GRCz10 10 15845220
GRCz11 10 15803339
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GCACCAGTTTGGTCGGACTGCCGCTCTCCACCTGCCAGAGCATCATTAAA[G/A]TATGGCTCGCTTCTTTTGCTAAATTTATTTGACATTTTTAACTTTTAATG
Long Flanking Sequence:
AGTCAGTTAAGATGTTAACATGTTGACAAAACCATCAGGTGGAATGTGGTGCAAATATAGCAATCATTTCTCTAACTTGACATAGCTAACACATTATTTTCAATATAACAAGACTATTGGCTAACATTCAGTGAATTTAGCCATAGACAGAGTGGTTTACTTCTAGAATGATCGATAACCATTGACTTCCATAGTATTTTTTCCACCGTTTTAAGGAAGTCAATGCTGACCCTCGACTGTTCTGATACCAGCATGTCCTGTGAGCCCTGCCTCTTTGTTTGTGTCAGGTGTACATCGAGAAGCAGAAGGGGGAGATTCTGGGTGTGGTGATTGTGGAGTCTGGCTGGGGCTCCATCCTGCCCACCGTCATCATCGCCAGCCTGATGCACGGTGGACCCGCAGCCAAATCCGGAAGACTCAACATCGGAGATCAAATCATGACCGTCAACGGCACCAGTTTGGTCGGACTGCCGCTCTCCACCTGCCAGAGCATCATTAAA[G/A]TATGGCTCGCTTCTTTTGCTAAATTTATTTGACATTTTTAACTTTTAATGTTGTGGAAATCTGTTCTGGTTCTTTAGATATTATTCAGGAAACAACCAAAGTCTACAAAAGAAGTCTGAAGTCGTTCTGAGTTACTCAGACTGAAGTGTTTATTGTCACAAGCGCAGTTTGCAACAACAGGGGCAATCTGATCAAATGTCCCACTGAGCAGCCCCTTTCATACAGTTTTTATACATATTGTCTTCCTCCCTTAGGGTTGATAACACATCATATCTCACCAATATCTACAGTTTGATCATTTGTCTTAGGGTGCTTTCACACCTGTGAATTGATTCAGTTGTTCCGAAACAGAGATTACAATTGTTACATTGTTGCTCTTTGCTCTTGGAGCGGTTTGCTTTCATACTGCAAAGTTTCTAATCGGACCAAAAAGCTAAAACAAGTCACGTGCGAGTAAACTCTCCTCACATTGGTCAGAGTGTCAGGGTTTATTTTGCAGC
Associated Phenotype:
Not determined