Busch Lab

ZMP

lef1

Ensembl ID:
ENSDARG00000031894
ZFIN ID:
ZDB-GENE-990714-26
Description:
lymphoid enhancer-binding factor 1 [Source:RefSeq peptide;Acc:NP_571501]
Human Orthologue:
LEF1
Human Description:
lymphoid enhancer-binding factor 1 [Source:HGNC Symbol;Acc:6551]
Mouse Orthologue:
Lef1
Mouse Description:
lymphoid enhancer binding factor 1 Gene [Source:MGI Symbol;Acc:MGI:96770]

Alleles

There are 4 alleles of this gene:

Allele Name Consequence Status Availability
sa10902 Essential Splice Site Available for shipment Available now
sa18709 Essential Splice Site Mutation detected in F1 DNA Not yet available
sa32764 Nonsense Mutation detected in F1 DNA Not yet available
sa39684 Essential Splice Site Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
sa10902
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000047876 Essential Splice Site 302 365 7 11
ENSDART00000132405 Essential Splice Site 302 365 7 11
ENSDART00000047876 Essential Splice Site 302 365 7 11
ENSDART00000132405 Essential Splice Site 302 365 7 11
Genomic Location (Zv9):
Chromosome 1 (position 50387446)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 49236537
GRCz11 1 49880363
KASP Assay ID:
2259-1084.1 (used for ordering genotyping assays)
KASP Sequence:
ATGCACGCTGAAGGAGAGCGCCGCTATCAATCAGATCCTCGGCCGGAGGG[T/C]TCGTATCTTAAAAWTCTTCCTTRTACGAATGGAGTTWGCACTTTTATCCA
Long Flanking Sequence:
TCAGGTCACGAACGCGAGTGAAGTATCGAGTCTCATAGACTTGGTTGGAATATTTAGGTTTGGTTGCCATTACTGGTGAAGTAATCTCTTTGCATGAAAGCACCCAACTGGACATAATTAAAAGCCGCTGCTTGCTTTTTCGGCACTGGCTCCCAGATTGTTCTCTCATGCAGCTTTCTGATTGGTGGTTGGAATCAGACATTCGGCGCTCTCTCACACTCAGTGGCGTCGCTGTGGCAGCCGCTTTCGCACCACCCTCTGAGCATTTTTTTGTATTTCCATGTATCACTTAATAATTCCCATCCCCCCCTTTTTTTTAACTCTTTCCTTCTTCAGGAAACCTCAGCACGAGCAGAGAAAGGAGCAGGAGCCCAAAAGACCTCACATCAAGAAACCTCTAAACGCTTTCATGCTGTATATGAAAGAGATGCGCGCCAATGTGGTGGCCGAATGCACGCTGAAGGAGAGCGCCGCTATCAATCAGATCCTCGGCCGGAGGG[T/C]TCGTATCTTAAAAATCTTCCTTATACGAATGGAGTTAGCACTTTTATCCATCTCGGATTAACCAGTACATCAAGCTGATGAATCAGAAATCAGTCAGGTAGTGCATATAACAGATTGTATTCCTGTGTTTTGGAATTGGAAAAAGAGCCACCGTTAAACATATTTAATGCCTTAACCAAAGCCTCTGTGGCTAGCCACAGCAAAGGAGCGTTTTGCGGCGGTGTGGGGTAATTGCACCCTGACATGGTTTGAAGTAAAGCGCCGCTAAATTGGAACCAGTGTTTTGATATGAAATCAAAGTTTCGTGTTTTTTTTTCTTCCTCTTCTCTCATCGCTGCATATGTTAATCTCTTCATCATGTTCCATTCCACCCCCAGGCACACACACACACACATGTACACACACACACACACGCAACATTTGAAAGTTAACAAGGGTTTCTAGCCAAACTCCAGCACGTGTCTCTTTGGAAGAAACTTAAAAGTGCATGTCAGTAATTG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa18709
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
T > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000047876 Essential Splice Site 302 365 7 11
ENSDART00000132405 Essential Splice Site 302 365 7 11
ENSDART00000047876 Essential Splice Site 302 365 7 11
ENSDART00000132405 Essential Splice Site 302 365 7 11
Genomic Location (Zv9):
Chromosome 1 (position 50387446)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 49236537
GRCz11 1 49880363
KASP Assay ID:
2259-1084.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ATGCACGCTGAAGGAGAGCGCCGCTATCAATCAGATCCTCGGCCGGAGGG[T/C]TCGTATCTTAAAAATCTTCCTTATACGAATGGAGTTAGCACTTTTATCCA
Long Flanking Sequence:
TCAGGTCACGAACGCGAGTGAAGTATCGAGTCTCATAGACTTGGTTGGAATATTTAGGTTTGGTTGCCATTACTGGTGAAGTAATCTCTTTGCATGAAAGCACCCAACTGGACATAATTAAAAGCCGCTGCTTGCTTTTTCGGCACTGGCTCCCAGATTGTTCTCTCATGCAGCTTTCTGATTGGTGGTTGGAATCAGACATTCGGCGCTCTCTCACACTCAGTGGCGTCGCTGTGGCAGCCGCTTTCGCACCACCCTCTGAGCATTTTTTTGTATTTCCATGTATCACTTAATAATTCCCATCCCCCCCTTTTTTTTAACTCTTTCCTTCTTCAGGAAACCTCAGCACGAGCAGAGAAAGGAGCAGGAGCCCAAAAGACCTCACATCAAGAAACCTCTAAACGCTTTCATGCTGTATATGAAAGAGATGCGCGCCAATGTGGTGGCCGAATGCACGCTGAAGGAGAGCGCCGCTATCAATCAGATCCTCGGCCGGAGGG[T/C]TCGTATCTTAAAAATCTTCCTTATACGAATGGAGTTAGCACTTTTATCCATCTCGGATTAACCAGTACATCAAGCTGATGAATCAGAAATCAGTCAGGTAGTGCATATAACAGATTGTATTCCTGTGTTTTGGAATTGGAAAAAGAGCCACCGTTAAACATATTTAATGCCTTAACCAAAGCCTCTGTGGCTAGCCACAGCAAAGGAGCGTTTTGCGGCGGTGTGGGGTAATTGCACCCTGACATGGTTTGAAGTAAAGCGCCGCTAAATTGGAACCAGTGTTTTGATATGAAATCAAAGTTTCGTGTTTTTTTTTCTTCCTCTTCTCTCATCGCTGCATATGTTAATCTCTTCATCATGTTCCATTCCACCCCCAGGCACACACACACACACATGTACACACACACACACACGCAACATTTGAAAGTTAACAAGGGTTTCTAGCCAAACTCCAGCACGTGTCTCTTTGGAAGAAACTTAAAAGTGCATGTCAGTAATTG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa32764
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000047876 Nonsense 345 365 9 11
ENSDART00000132405 Nonsense 345 365 9 11
Genomic Location (Zv9):
Chromosome 1 (position 50392549)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 49241640
GRCz11 1 49885466
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
CCCTCAATATTCATCATTTGTTTTTTTTATAGGGAAAGAAAAAAAAGCGG[A/T]AGAGGGAAAAGATCCAGGAACCTGCTTCAGGTGAGACTCAATAACCTTCT
Long Flanking Sequence:
TGCTTGATTATATTTAAATGTTTATATATTTTATTATATTTTTATTTTATGTTTATATATTTTAATATATTTTCTATTTTTTATTTTACTTGTTTGATTTTATTTAAATGTTTATAAAATTTTATTTATATTTTTTTAAATTAATTTTACTCGCTTGATTATATTTAAATGTTTATATATTTTAATAATTTTACTTGATTATATTTAAATATTAATATATTTTAACATATTTTTATTTTATGTTTATATATTTTCATATATTTTTTATTTTATTTATTTGTTTGATTTTATTGAAATGTTTTTATATTTTATTTGATTTCATTTAAATGTTTACAAAACTTAATTGACGTAATTTTGTTTTATTTTACTTAAACTTTTTGTATTTTGTTGTAACTTTAGTTTAGTGTTGAGTAATGTATTATTTATTTTATTTTAATAGTTTTTTAAAGACCCTCAATATTCATCATTTGTTTTTTTTATAGGGAAAGAAAAAAAAGCGG[A/T]AGAGGGAAAAGATCCAGGAACCTGCTTCAGGTGAGACTCAATAACCTTCTATCCATGCTGATATTTGTGCAGTTTTGTTAATACATGCTCTAAATAAGCTCCATGTCACTTACTTTGCAACTAATGTGGTTAATGATGGGGTTTCGCATCCTCAATATGCACTTTCAGCCAACTTCAATCACAAACTGATGAAGATGAACATTCATTTAAGACTTTGTTTGTTGCCTAAAAATTAAGTTCTGTACATACTTTTCATTTGCATATACATTATGAACAGAGCATCCCACCACTCCATCTTTCATCCTCTCACAATTCAGTCTTTAGGATTAGTCTGTTTAAAAATAAAAATAAAAGCCTCCACATGCTTCCTTCAGTGCTTTCTGCTCTTTTATAAACGCATTAGCAATGTATGCTTAACACTTCAATGTTTGTCTGGCACTAAATCTAGATGATATCATTAAAACTTGTGTATAATGTAAAAGTTAAAGTGATAGTTCACC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa39684
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000047876 Essential Splice Site 354 365 9 11
ENSDART00000132405 Essential Splice Site 354 365 9 11
Genomic Location (Zv9):
Chromosome 1 (position 50392580)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 49241671
GRCz11 1 49885497
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GGGAAAGAAAAAAAAGCGGAAGAGGGAAAAGATCCAGGAACCTGCTTCAG[G/A]TGAGACTCAATAACCTTCTATCCATGCTGATATTTGTGCAGTTTTGTTAA
Long Flanking Sequence:
TATTATATTTTTATTTTATGTTTATATATTTTAATATATTTTCTATTTTTTATTTTACTTGTTTGATTTTATTTAAATGTTTATAAAATTTTATTTATATTTTTTTAAATTAATTTTACTCGCTTGATTATATTTAAATGTTTATATATTTTAATAATTTTACTTGATTATATTTAAATATTAATATATTTTAACATATTTTTATTTTATGTTTATATATTTTCATATATTTTTTATTTTATTTATTTGTTTGATTTTATTGAAATGTTTTTATATTTTATTTGATTTCATTTAAATGTTTACAAAACTTAATTGACGTAATTTTGTTTTATTTTACTTAAACTTTTTGTATTTTGTTGTAACTTTAGTTTAGTGTTGAGTAATGTATTATTTATTTTATTTTAATAGTTTTTTAAAGACCCTCAATATTCATCATTTGTTTTTTTTATAGGGAAAGAAAAAAAAGCGGAAGAGGGAAAAGATCCAGGAACCTGCTTCAG[G/A]TGAGACTCAATAACCTTCTATCCATGCTGATATTTGTGCAGTTTTGTTAATACATGCTCTAAATAAGCTCCATGTCACTTACTTTGCAACTAATGTGGTTAATGATGGGGTTTCGCATCCTCAATATGCACTTTCAGCCAACTTCAATCACAAACTGATGAAGATGAACATTCATTTAAGACTTTGTTTGTTGCCTAAAAATTAAGTTCTGTACATACTTTTCATTTGCATATACATTATGAACAGAGCATCCCACCACTCCATCTTTCATCCTCTCACAATTCAGTCTTTAGGATTAGTCTGTTTAAAAATAAAAATAAAAGCCTCCACATGCTTCCTTCAGTGCTTTCTGCTCTTTTATAAACGCATTAGCAATGTATGCTTAACACTTCAATGTTTGTCTGGCACTAAATCTAGATGATATCATTAAAACTTGTGTATAATGTAAAAGTTAAAGTGATAGTTCACCCAAAAATGAGACATCATTTACCCTTGTGTTT
Associated Phenotype:
Not determined