Busch Lab

ZMP

otx2

Ensembl ID:
ENSDARG00000011235
ZFIN ID:
ZDB-GENE-980526-406
Description:
Homeobox protein OTX2 [Source:UniProtKB/Swiss-Prot;Acc:Q91981]
Human Orthologues:
OTX1, OTX2
Human Descriptions:
orthodenticle homeobox 1 [Source:HGNC Symbol;Acc:8521]
orthodenticle homeobox 2 [Source:HGNC Symbol;Acc:8522]
Mouse Orthologues:
Otx1, Otx2
Mouse Descriptions:
orthodenticle homolog 1 (Drosophila) Gene [Source:MGI Symbol;Acc:MGI:97450]
orthodenticle homolog 2 (Drosophila) Gene [Source:MGI Symbol;Acc:MGI:97451]

Alleles

There are 3 alleles of this gene:

Allele Name Consequence Status Availability
hu3625 Essential Splice Site Available for shipment Available now
hu3237 Nonsense Confirmed mutation in F2 line Not yet available
sa36505 Nonsense Mutation detected in F1 DNA Not yet available

Mutation Details

Allele Name:
hu3625
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
A > C
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000008816 Essential Splice Site 84 289 4 4
ENSDART00000126097 Essential Splice Site 84 289 3 3
Genomic Location (Zv9):
Chromosome 17 (position 44292923)
Other Location(s):
Assembly Chromosome Position
GRCz10 17 44132601
GRCz11 17 44246366
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GCCGTTAGTTCACGTCGTAAATAATAAAAACCCCTTTTTTTCAACACATC[A/C]GGTTTGGTTCAAAAACCGAAGGGCAAAGTGTCGCCAACAGCAGCAACAAC
Long Flanking Sequence:
TGTATAACATGTTGTACTGTGCCGATTCAGATATGTTAATGTGTAATATTTATAGTATTTTTTACATTTAATAATTAAATCTAAGCATGGACGTTTTTTATTAAATGACAACCTGTGATGCTTTTGTTTATTTAAAACAGCGACTCCTCGAAAGCAGAGACGAGAAAGGACAACATTTACTAGAGCGCAACTAGATGTGCTGGAGGCTTTATTCGCGAAAACACGCTACCCGGATATTTTCATGCGCGAGGAGGTGGCCTTGAAAATCAACTTGCCGGAGTCCCGTGTACAGGTACGCATCTTTCAACTCATGAGAAAGTTAAATAATTATAATAATAATAAAAGTATTGTATCTATATGAACTGAGCGATGCACTAAAATATTATCAATATCACATTTGTTTTATTTTGAGCGAAGACCAAACAGAGCATATATAAAGACCATAGTGCTGCCGTTAGTTCACGTCGTAAATAATAAAAACCCCTTTTTTTCAACACATC[A/C]GGTTTGGTTCAAAAACCGAAGGGCAAAGTGTCGCCAACAGCAGCAACAACAACAAAACGGAGGCCAGAACAAGGTGCGACCTGCCAAAAAGAAGAGCTCTCCAGCGCGGGAGGCCAGTTCTGAGAGCGGGGCGAGTGGCCAGTTCACCCCGCCCTCCAGCACTTCAGTCCCGGCCATCTCTACCACAACCGCTCCGGTGTCTATTTGGAGCCCAGCCTCTATCTCGCCGCTGTCAGACCCACTTTCTACCTCCTCCTCCTGCATGCAAAGATCCTACCCCATGACCTACACTCAAGCGTCTGGATATAGCCAGGGCTATGCTGGTTCCACTTCCTACTTTGGGGGTATGGACTGCGGCTCATACTTGACGCCCATGCACCATCAGCTGACCGGGCCGGGATCCACTTTGAGCCCCATGAGCAGCAACGCTGTCACCAGTCACCTAAATCAGTCCCCCGCGTCCCTCCCCACACAAGGTTACGGTGCCTCGGGGCTCGGCT
Associated Phenotype:
Normal
Stage Entity Quality Tag
Larval:Day 5
ZFS:0000037		 whole organism
ZFA:0001094		 quality
PATO:0000001		 normal
PATO:0000461

Mutation Details

Allele Name:
hu3237
Status:
Confirmed mutation in F2 line
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
A > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000008816 Nonsense 87 289 4 4
ENSDART00000126097 Nonsense 87 289 3 3
Genomic Location (Zv9):
Chromosome 17 (position 44292912)
Other Location(s):
Assembly Chromosome Position
GRCz10 17 44132590
GRCz11 17 44246355
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
ACGTCGTAAATAATAAAAACCCCTTTTTTTCAACACATCAGGTTTGGTTC[A/T]AAAACCGAAGGGCAAAGTGTCGCCAACAGCAGCAACAACAACAAAACGGA
Long Flanking Sequence:
TTGTACTGTGCCGATTCAGATATGTTAATGTGTAATATTTATAGTATTTTTTACATTTAATAATTAAATCTAAGCATGGACGTTTTTTATTAAATGACAACCTGTGATGCTTTTGTTTATTTAAAACAGCGACTCCTCGAAAGCAGAGACGAGAAAGGACAACATTTACTAGAGCGCAACTAGATGTGCTGGAGGCTTTATTCGCGAAAACACGCTACCCGGATATTTTCATGCGCGAGGAGGTGGCCTTGAAAATCAACTTGCCGGAGTCCCGTGTACAGGTACGCATCTTTCAACTCATGAGAAAGTTAAATAATTATAATAATAATAAAAGTATTGTATCTATATGAACTGAGCGATGCACTAAAATATTATCAATATCACATTTGTTTTATTTTGAGCGAAGACCAAACAGAGCATATATAAAGACCATAGTGCTGCCGTTAGTTCACGTCGTAAATAATAAAAACCCCTTTTTTTCAACACATCAGGTTTGGTTC[A/T]AAAACCGAAGGGCAAAGTGTCGCCAACAGCAGCAACAACAACAAAACGGAGGCCAGAACAAGGTGCGACCTGCCAAAAAGAAGAGCTCTCCAGCGCGGGAGGCCAGTTCTGAGAGCGGGGCGAGTGGCCAGTTCACCCCGCCCTCCAGCACTTCAGTCCCGGCCATCTCTACCACAACCGCTCCGGTGTCTATTTGGAGCCCAGCCTCTATCTCGCCGCTGTCAGACCCACTTTCTACCTCCTCCTCCTGCATGCAAAGATCCTACCCCATGACCTACACTCAAGCGTCTGGATATAGCCAGGGCTATGCTGGTTCCACTTCCTACTTTGGGGGTATGGACTGCGGCTCATACTTGACGCCCATGCACCATCAGCTGACCGGGCCGGGATCCACTTTGAGCCCCATGAGCAGCAACGCTGTCACCAGTCACCTAAATCAGTCCCCCGCGTCCCTCCCCACACAAGGTTACGGTGCCTCGGGGCTCGGCTTCAACTCCACC
Associated Phenotype:
Normal
Stage Entity Quality Tag
Larval:Day 5
ZFS:0000037		 whole organism
ZFA:0001094		 quality
PATO:0000001		 normal
PATO:0000461

Mutation Details

Allele Name:
sa36505
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000008816 Nonsense 100 289 4 4
ENSDART00000126097 Nonsense 100 289 3 3
Genomic Location (Zv9):
Chromosome 17 (position 44292873)
Other Location(s):
Assembly Chromosome Position
GRCz10 17 44132551
GRCz11 17 44246316
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
AGGTTTGGTTCAAAAACCGAAGGGCAAAGTGTCGCCAACAGCAGCAACAA[C/T]AACAAAACGGAGGCCAGAACAAGGTGCGACCTGCCAAAAAGAAGAGCTCT
Long Flanking Sequence:
TATAGTATTTTTTACATTTAATAATTAAATCTAAGCATGGACGTTTTTTATTAAATGACAACCTGTGATGCTTTTGTTTATTTAAAACAGCGACTCCTCGAAAGCAGAGACGAGAAAGGACAACATTTACTAGAGCGCAACTAGATGTGCTGGAGGCTTTATTCGCGAAAACACGCTACCCGGATATTTTCATGCGCGAGGAGGTGGCCTTGAAAATCAACTTGCCGGAGTCCCGTGTACAGGTACGCATCTTTCAACTCATGAGAAAGTTAAATAATTATAATAATAATAAAAGTATTGTATCTATATGAACTGAGCGATGCACTAAAATATTATCAATATCACATTTGTTTTATTTTGAGCGAAGACCAAACAGAGCATATATAAAGACCATAGTGCTGCCGTTAGTTCACGTCGTAAATAATAAAAACCCCTTTTTTTCAACACATCAGGTTTGGTTCAAAAACCGAAGGGCAAAGTGTCGCCAACAGCAGCAACAA[C/T]AACAAAACGGAGGCCAGAACAAGGTGCGACCTGCCAAAAAGAAGAGCTCTCCAGCGCGGGAGGCCAGTTCTGAGAGCGGGGCGAGTGGCCAGTTCACCCCGCCCTCCAGCACTTCAGTCCCGGCCATCTCTACCACAACCGCTCCGGTGTCTATTTGGAGCCCAGCCTCTATCTCGCCGCTGTCAGACCCACTTTCTACCTCCTCCTCCTGCATGCAAAGATCCTACCCCATGACCTACACTCAAGCGTCTGGATATAGCCAGGGCTATGCTGGTTCCACTTCCTACTTTGGGGGTATGGACTGCGGCTCATACTTGACGCCCATGCACCATCAGCTGACCGGGCCGGGATCCACTTTGAGCCCCATGAGCAGCAACGCTGTCACCAGTCACCTAAATCAGTCCCCCGCGTCCCTCCCCACACAAGGTTACGGTGCCTCGGGGCTCGGCTTCAACTCCACCGCGGATTGCTTGGATTATAAGGACCAAGCGTCCTCATGG
Associated Phenotype:
Not determined