Busch Lab

ZMP

ptenb

Ensembl ID:
ENSDARG00000056623
ZFIN ID:
ZDB-GENE-030616-47
Description:
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Human Orthologue:
PTEN
Human Description:
phosphatase and tensin homolog [Source:HGNC Symbol;Acc:9588]
Mouse Orthologue:
Pten
Mouse Description:
phosphatase and tensin homolog Gene [Source:MGI Symbol;Acc:MGI:109583]

Alleles

There are 4 alleles of this gene:

Allele Name Consequence Status Availability
sa44756 Essential Splice Site Mutation detected in F1 DNA Not yet available
hu1435 Nonsense Available for shipment Available now
sa17852 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa44756
Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Not yet available
Mutation:
G > A
Consequence:
Essential Splice Site
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000079138 Essential Splice Site 55 422 2 10
ENSDART00000079144 Essential Splice Site 55 399 2 9
Genomic Location (Zv9):
Chromosome 12 (position 18487481)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 17298058
GRCz11 12 17419932
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
GCTGAAAGACTGGAGGGTGTATATAGAAACAACATAGATGATGTAGTGAG[G/A]TAAGTATTCACTTTGTTCTTGCTAGAGATTTTGTCAGGATAACCATTTTG
Long Flanking Sequence:
AAAGTGATTCCAGGCTGGGCTGAGGCACAGTGTGATTTATTTAGTGCCCCTGTGTGGCCCTCTGGGTTAGAGGTCTATGCATTGGTCTCTTGCAGCGAGAGCCATCTGTTCTATATTACCCAGAATCCTGTTATCTGAGCTCTCATTGCTCAACTAAAAAGAAAAGCGCTGCTTTAGTGGAAATGCTGAAGTTCTCCGTTGAAACCGAGGCTTGATGTTTGTTGGTTTTCCTGCTCCTTGTGGCGTCATTTGACTGCACTGCATTGTTCACCAACCTTGCCTCAGAGTTTTGGATGCAATTTAAGACAAGCATCCGGTGGACTTTACATGTGTATTCATGTTTAATCAGATGTTATGTAGTTTTGTTTTCCTGTTCATATCAACTTTTCTAGATTTCCTTAACGCTGCTGTACAGACATTTATCCTAACATAATAGCTATGGGTTTCCCTGCTGAAAGACTGGAGGGTGTATATAGAAACAACATAGATGATGTAGTGAG[G/A]TAAGTATTCACTTTGTTCTTGCTAGAGATTTTGTCAGGATAACCATTTTGTGTTTGTGTGCCACTTCACATTTACAACCCATGTTGCAACCCCCACCAAAAAAAAAAAAAAAAAAAGCTGCTGTGATATTTACAGCCATGTCGAACTGGACCTGCCAGATAATGTTCCATTCCATTGACTCTTGCTGTTTTATCAGTTTGTGGTAGTTGAGTATTTGTGATGTAAAATGCTGGATAGTAAATATAACTGACTGTGTTGCATAAAAGGGGTCTTTTTTGGTTAAAGTAATATTTTATTTTATCTTTATTTTATGTTTAAAAAAAACATTGTTTTTTTTTTAGCAATTTCGACACCCCATCCCCAAATCAATTCATTTATATGCATGCATTTAGCATATCTTTTAATCCAAAGTGGTTTGTCTTAAGCGGGAATCGTATATCAAAATAGTGTGGGAAATTGTGTTGAATGGAGGCGGATATCTTTATGTTGGTCCAAACCCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
hu1435
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > A
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000079138 Nonsense 65 422 3 10
ENSDART00000079144 Nonsense 65 399 3 9
Genomic Location (Zv9):
Chromosome 12 (position 18482481)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 17293058
GRCz11 12 17414932
KASP Assay ID:
554-0393.1 (used for ordering genotyping assays)
KASP Sequence:
None
Flanking Sequence:
TGTTCTATCTTGTTTTGCAGGTTTCTTGATTCAAAGCATAAAGATCATTA[C/A]AAGATATATAACCTGTAAGTGTGTTTCAAAAACTTCAGTTCTGTGATATC
Long Flanking Sequence:
TTTAAAAGCAAATCAGTTTTAATCTTCTGAAGAGACATGAAGTTATAAATTAAGGATTTTATTAACATATAACAATTGATCATCTGACATATGTTGTAAATATTGTAAACTTGACTCTCAATTGTACTTGATTGACGTGAGAATTAATGAGGCTTGGTCTCATGTCCCACTAGCACATTTGATCTTCCATATGAACCAGTAAGGTGTTAATCAGTATTTGTAAGTGAATAAAAACCTAAATGAAATCTGTCCATCAAGTCCATTTCAGGAGACTTGCTTTAAAGCACTTGATTCGGATTGATTACATTTAAGCATAACTATTTTGAAGGACTTTCAATGAAAGAACAGAAATCCAGTTCCATTAAAATACCTTCATTTGTTTTTTTTTGTTTTTTTGTTGAGCTTTTGTTGGATGAACTATTCCTTTAATTAAAATCTATAACATGCTTTTGTTCTATCTTGTTTTGCAGGTTTCTTGATTCAAAGCATAAAGATCATTA[C/A]AAGATATATAACCTGTAAGTGTGTTTCAAAAACTTCAGTTCTGTGATATCGGTTTTGTAAATGGGTTTCATCAAACTGCTTTTACTGCTAGAATGTTCTGAAAGCTGCAATCATGTTCACTTGAAGATTAAGGCGGCTGTTTGATCGTTGTGAATGGAGGGCTTTGTCATTGCACATAGATCCCTTACTTAACTCCGATTGTTCTGTTGGTTTTGGCATTGGTGCAAAGTTCTAAGCAGAAAAGTATTATGTTGAACTTGTGTACTTATCTGCTTTACTTTGTGTTGTTTAGATGTGCAGAAAGACATTACGATACTGCCAAATTTAACTGCAGAGGTAAGAGGCTTGGATTGCATAAATGTCAGTTTTTGTGTGGTAACGTTGATGGTCTCTCAATGATCTCTTTATTTATCTTTTGCAGTTGCACAGTATCCATTTGAGGATCACAATCCTCCTCAGCTAGAGCTCATTAAACCTTTCTGTGAAGATTTGGATAAATG
Associated Phenotype:
Normal
Stage Entity Quality Tag
Larval:Day 5
ZFS:0000037		 whole organism
ZFA:0001094		 quality
PATO:0000001		 normal
PATO:0000461

Mutation Details

Allele Name:
sa17852
Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
C > T
Consequence:
Nonsense
Transcripts:
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000079138 Nonsense 284 422 8 10
ENSDART00000079144 Nonsense 261 399 7 9
Genomic Location (Zv9):
Chromosome 12 (position 18473094)
Other Location(s):
Assembly Chromosome Position
GRCz10 12 17283671
GRCz11 12 17405545
KASP Assay ID:
None (used for ordering genotyping assays)
KASP Sequence:
CTCAACCACTGCCTGTGTGTGGGGACATCAAGGTGGAGTTCTTCCACAAA[C/T]AAAACAAGAWGATGAAGAAGGTATGAGTYCGTTCTAAACAGCCTAGTGTG
Long Flanking Sequence:
TCAGCTTTTTCTAAAATGTTTTTCACTTTCAGTTCTGTTAGATTAGTCAGTGTTGCTGTTTAGATTGTATTTGCCATGTACAAGTAAAATCCTCGAGTGCCACTTTTGGGTGGTCGTTTGTAATGCCCCATTCGAGGCAGGCGAGAAGAGTGGTCTTGGGTCAGCGGTCCACAGAATTAGGCTCTTCAGCATTTTAATGTTGTCTTTTCTGCATCAATATTTCATCTGTTTCCACCCACTTCTTTTTTCCCCCTCTATGCTTCTCTTTTGTTTCACATTAACAGTTATTCATAAGCTCACAGTTGTTTGTTGCACATAGCCGGAACAGCAATTACACATCACTTTATTTTGCAGATCCTCAGTTTGTGGTGTACCAGCTGAAGGTGAAAATTCACACCTCAAACCCAGCGCACACAAGAAGAGAGGAGAAGTACATGTTCTTCGAATTTCCTCAACCACTGCCTGTGTGTGGGGACATCAAGGTGGAGTTCTTCCACAAA[C/T]AAAACAAGATGATGAAGAAGGTATGAGTTCGTTCTAAACAGCCTAGTGTGTACTTGCAGATCTTTATTGCTTTTCATTACAGCATCTTTTAGCTGTAATGCTAAGAGGGAGGACATTTAATTTTTCTTTAATCAGATTTATATCTATTTACTTATTATTTAGTATATATAACATTTTATTTTATATGATAGGTTTTTCATATTCAAATTAAATGATACAAAGGAAGTTTTAAATGCAATTTATTATTTAATTGAAGCTTGAAGCAAAGATAATTCATTTTTTTATCGCAAATGAATAAAAAATCTGGAATTAATGCCAAAACTGTGTTATATGGGGTTGGGTGTAGAGGTCTGCACAGGACTGGTTTTATTGTCCCACTCGCCACCAGGTTTTATTCTGCTCCTGATCGTTCCTGCTGTATATTCGGTCTTTGTTCTAGAGCTGCCTGTTTAGAATGTTTATTTTTTTATTTATTTATTTATTTTTTTTACCCGACCCAA
Associated Phenotype:
Not determined